WordNet

a treatment for addiction to drugs or alcohol intended to remove the physiological effects of the addictive substances
treatment for poisoning by neutralizing the toxic properties (normally a function of the liver)
remove poison from; "detoxify the soil" (同)detoxicate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/31 09:07:18」(JST)

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Detoxication products are the major metabolites formed from most drug metabolism. There are two common patterns observed:

A drug with potent pharmacological activity is converted to a major metabolite with markedly reduced or no pharmacological activity (e.g., Pentobarbital and Hydroxypentobarbital)
A drug is converted to a metabolite with roughly equivalent or slightly lower pharmacological activity.

Detoxication differs from detoxification.^{[citation needed]} Detoxification is the process of removing toxins from the body, while detoxication is the process of preventing toxic entities from entering the body in the first place.^{[citation needed]} Detoxication occurs in the liver and kidneys, through biotransformation: a series of chemical alterations of a compound (e.g., a drug) occurring within the body, as by enzymatic activity. Often this occurs as conjugation with a polar compound making it less toxic and or easier to excrete. Example of detoxification are: Administration of chelators for heavy metal poisoning,^{[citation needed]} hyperbaric oxygen treatment for carbon monoxide poisoning^{[citation needed]}and treatment of ethylene glycol poisoning with ethanol.^{[citation needed]}

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English Journal

The contribution of human small intestine to chlorpyrifos biotransformation.

Leoni C, Balduzzi M, Buratti FM, Testai E.SourceEnvironment and Primary Prevention Department, Mechanisms of Toxicity Unit, Istituto Superiore di Sanità, Viale Regina Elena, 299, Istituto Superiore di Sanità, Italy.
Toxicology letters.Toxicol Lett.2012 Oct 2. pii: S0378-4274(12)01321-5. doi: 10.1016/j.toxlet.2012.09.016. [Epub ahead of print]
Despite the oral intake is the major route of exposure to chlorpyrifos for the general population, few data are available on human intestine biotransformation. In this study the contribution of chlorpyrifos (CPF) metabolism in human small intestine was investigated in microsomes from duodenum (HDM)
PMID 23036741

Phenotyping drug disposition in oncology.

Opdam FL, Gelderblom H, Guchelaar HJ.SourceDepartment of Clinical Pharmacy, University Medical Center, Leiden, The Netherlands. f.l.opdam@lumc.nl
Cancer treatment reviews.Cancer Treat Rev.2012 Oct;38(6):715-25. Epub 2012 Jan 4.
Efficacy and toxicity of anticancer agents are highly variable between patients and variation in drug disposition is thought to be an important determinant. Genetics, physiology, and environment all are underlying factors contributing to this variation. Phenotyping drug metabolizing enzymes and drug
PMID 22226243

Japanese Journal

A-7 生物発光に基づく細胞毒性試験法のレジンモノマー開発への応用(細胞・毒性,一般講演(口頭発表),第62回日本歯科理工学会学術講演会)

江頭美喜,折本愛,鈴木崇弘,水野光政,上野温子,藤本耕太郎,河合達志
日本歯科理工学会誌 32(5), 329, 2013-09-25
… It is suggested that this system will be useful to evaluate the detoxication metabolism of inner cells, and may attribute to develop new monomers applicable in dentistry. …
NAID 110009674216

8074 石綿(アスベスト)飛散リスクの軽減と無害化・循環利用に係る事業化要件の算定手法に関する研究 : ネットリサーチによる認知度の簡易調査(安全・災害,建築社会システム,2013年度日本建築学会大会(北海道)学術講演会・建築デザイン発表会)

内田季延
学術講演梗概集 2013(建築社会システム), 147-148, 2013-08-30
NAID 110009677979

Synthetic Models Related to Methoxalen and Menthofuran–Cytochrome P450 (CYP) 2A6 Interactions : Benzofuran and Coumarin Derivatives as Potent and Selective Inhibitors of CYP2A6

Yamaguchi Yuki,Akimoto Ichie,Motegi Kyoko [他],Yoshimura Teruki,Wada Keiji,Nishizono Naozumi,Oda Kazuaki
Chemical and Pharmaceutical Bulletin 61(10), 997-1001, 2013
… Human microsomal cytochrome P450 (CYP) 2A6 contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. …
NAID 130003360906