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English Journal

Plasma concentrations of efavirenz, darunavir/ritonavir and raltegravir in HIV-HCV-coinfected patients without liver cirrhosis in comparison with HIV-monoinfected patients.

Calza L1, Danese I, Colangeli V, Manfredi R, Magistrelli E, Verucchi G, Conti M, Motta R, Viale P.
Infectious diseases (London, England).Infect Dis (Lond).2015 Sep;47(9):625-36. doi: 10.3109/23744235.2015.1034169. Epub 2015 Apr 15.
BACKGROUND: The objective of the study was to assess plasma concentrations of efavirenz, darunavir/ritonavir and raltegravir in patients with human immunodeficiency virus-hepatitis C virus (HIV-HCV)-coinfection without liver cirrhosis.METHODS: In this observational, open-label study, adult HIV-infec
PMID 25875396

Safety, efficacy and indications of prescription of maraviroc in clinical practice: Factors associated with clinical outcomes.

Llibre JM1, Rivero A2, Rojas JF3, Garcia Del Toro M4, Herrero C5, Arroyo D6, Pineda JA7, Pasquau J8, Masiá M9, Crespo M10, Blanco JR11, Moreno S12.
Antiviral research.Antiviral Res.2015 Aug;120:79-84. doi: 10.1016/j.antiviral.2015.05.001. Epub 2015 May 12.
Maraviroc is approved for treatment-experienced HIV+ adults in twice-daily administration. Limited data are available on safety, efficacy and use in routine clinical practice, outside of restrictive clinical trials. This retrospective multicenter (27 centers) study included 667 subjects starting a r
PMID 25977241

The Lipid-Lowering Effect of Tenofovir/Emtricitabine: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial.

Santos JR1, Saumoy M2, Curran A3, Bravo I4, Llibre JM1, Navarro J3, Estany C4, Podzamczer D2, Ribera E3, Negredo E5, Clotet B6, Paredes R6; Tenofovir/emtricitabine inflUence on LIPid metabolism (TULIP) Study Group.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.Clin Infect Dis.2015 Aug 1;61(3):403-408. Epub 2015 Apr 13.
BACKGROUND: It is unknown if tenofovir disoproxil fumarate (TDF), which is often coformulated with the lipid-neutral emtricitabine (FTC), has a lipid-lowering effect.METHODS: We performed a randomized, crossover, double-blind, placebo-controlled clinical trial on human immunodeficiency virus t
PMID 25870325

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