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1. ジストニアの分類および評価 classification and evaluation of dystonia
2. 重度複合型免疫不全（SCID）：特定の欠損 severe combined immunodeficiency scid specific defects
3. フェニルケトン尿症の概要 overview of phenylketonuria
4. 小児における運動過多な運動障害 hyperkinetic movement disorders in children

English Journal

Enhanced activation of NAD(P)H: quinone oxidoreductase 1 attenuates spontaneous hypertension by improvement of endothelial nitric oxide synthase coupling via tumor suppressor kinase liver kinase B1/adenosine 5'-monophosphate-activated protein kinase-mediated guanosine 5'-triphosphate cyclohydrolase 1 preservation.

Kim YH, Hwang JH, Kim KS, Noh JR, Gang GT, Oh WK, Jeong KH, Kwak TH, Choi HS, Lee IK, Lee CH.Author information aLaboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon bKorea Bioactive Natural Material Bank, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul cDiabetes and Metabolic Disease Research Center, Lee Gil Ya Cancer & Diabetes Institute, Gachon University of Medicine, Incheon dKT&G Life Sciences Corporation/R&D Center, Suwon eHormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju fDepartment of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea.AbstractAIMS: Guanosine 5'-triphosphate cyclohydrolase-1 (GTPCH-1) is a rate-limiting enzyme in de-novo synthesis of tetrahydrobiopterin (BH4), an essential cofactor for endothelial nitric oxide synthase (eNOS) coupling. Adenosine 5'-monophosphate-activated protein kinase (AMPK) is crucial for GTPCH-1 preservation, and tumor suppressor kinase liver kinase B1 (LKB1), an upstream kinase of AMPK, is activated by NAD-dependent class III histone deacetylase sirtuin 1 (SIRT1)-mediated deacetylation. β-Lapachone has been shown to increase cellular NAD/NADH ratio via
Journal of hypertension.J Hypertens.2014 Feb;32(2):306-17. doi: 10.1097/HJH.0000000000000018.
AIMS: Guanosine 5'-triphosphate cyclohydrolase-1 (GTPCH-1) is a rate-limiting enzyme in de-novo synthesis of tetrahydrobiopterin (BH4), an essential cofactor for endothelial nitric oxide synthase (eNOS) coupling. Adenosine 5'-monophosphate-activated protein kinase (AMPK) is crucial for GTPCH-1 prese
PMID 24241058

Sinorhizobium meliloti flavin secretion and bacteria-host interaction: Role of the bifunctional RibBA protein.

Yurgel SN, Rice J, Domreis E, Lynch J, Sa N, Qamar Z, Rajamani S, Gao M, Roje S, Bauer W.Author information Washington State University , Institute of Biological Chemistry , Pullman, WA, 99164-6340 , Pullman, Washington, United States, 99164-6340 ; syurgel@wsu.edu.AbstractSinorhizobium meliloti, the nitrogen-fixing bacterial symbiont of Medicago and other legumes, secretes a considerable amount of riboflavin. This precursor of the cofactors FMN and FAD is a bioactive molecule that has a beneficial effect on plant growth. The ribBA gene of S. meliloti codes for a putative bifunctional enzyme with dihydroxybutanone phosphate synthase and GTP cyclohydrolase II activities, catalyzing the initial steps of the riboflavin biosynthesis pathway. We show here that an in-frame deletion of ribBA does not cause riboflavin auxotrophy or affect the ability of S. meliloti to establish an effective symbiosis with the host plant, but does affect the ability of the bacteria to secrete flavins, colonize host-plant roots and compete for nodulation. A strain missing the RibBA protein retains considerable GTP cyclohydrolase II activity. Based on these results, we hypothesize that S. meliloti has two partly interchangeable modules for biosynthesis of riboflavin, one fulfilling the internal need for flavins in bacterial metabolism and the other producing riboflavin for secretion. Our data also indicate that bacteria-derived flavins play a role in communication between rhizobia and the legume host and that the RibBA protein is important in this communication process even though it is not essential for riboflavin biosynthesis and symbiosis.
Molecular plant-microbe interactions : MPMI.Mol Plant Microbe Interact.2014 Jan 3. [Epub ahead of print]
Sinorhizobium meliloti, the nitrogen-fixing bacterial symbiont of Medicago and other legumes, secretes a considerable amount of riboflavin. This precursor of the cofactors FMN and FAD is a bioactive molecule that has a beneficial effect on plant growth. The ribBA gene of S. meliloti codes for a puta
PMID 24405035

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers.

Lopresti AL, Maker GL, Hood SD, Drummond PD.Author information School of Psychology and Exercise Science, Murdoch University, Perth, Western Australia, 6150, Australia. Electronic address: a.lopresti@murdoch.edu.au.AbstractBiomarkers are regularly used in medicine to provide objective indicators of normal biological processes, pathogenic processes or pharmacological responses to therapeutic interventions, and have proved invaluable in expanding our understanding and treatment of medical diseases. In the field of psychiatry, assessment and treatment has, however, primarily relied on patient interviews and questionnaires for diagnostic and treatment purposes. Biomarkers in psychiatry present a promising addition to advance the diagnosis, treatment and prevention of psychiatric diseases. This review provides a summary on the potential of peripheral biomarkers in major depression with a specific emphasis on those related to inflammatory/immune and oxidative stress/antioxidant defences. The complexities associated with biomarker assessment are reviewed specifically around their collection, analysis and interpretation. Focus is placed on the potential of peripheral biomarkers to aid diagnosis, predict treatment response, enhance treatment-matching, and prevent the onset or relapse of major depression.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2014 Jan 3;48:102-11. doi: 10.1016/j.pnpbp.2013.09.017. Epub 2013 Oct 5.
Biomarkers are regularly used in medicine to provide objective indicators of normal biological processes, pathogenic processes or pharmacological responses to therapeutic interventions, and have proved invaluable in expanding our understanding and treatment of medical diseases. In the field of psych
PMID 24104186