Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/17 07:33:05」(JST)

In enzymology, a methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) is an enzyme that catalyzes the chemical reaction

5,10-methenyltetrahydrofolate + H₂O 10-formyltetrahydrofolate

Thus, the two substrates of this enzyme are 5,10-methenyltetrahydrofolate and H₂O, whereas its product is 10-formyltetrahydrofolate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines.

This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate.

Synonyms

The systematic name of this enzyme class is 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing).

Other names in common use include:

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1A4I, 1DIA, 1DIB, 1DIG, 2C2X, and 2C2Y.

Rabinowitz JC and Pricer WE (1956). "The enzymatic synthesis of N10-formyltetrahydrofolic acid and its role in ATP formation during formiminoglycine degradation". J. Am. Chem. Soc. 78 (16): 4176–4178. doi:10.1021/ja01597a094.
Tabor H and Wyngarden L (1959). "The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid". J. Biol. Chem. 234 (7): 1830–1849. PMID 13672973.

This hydrolase article is a stub. You can help Wikipedia by expanding it.

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

Suppression of MTHFD2 in MCF-7 Breast Cancer Cells Increases Glycolysis, Dependency on Exogenous Glycine, and Sensitivity to Folate Depletion.

Koufaris C1,2, Gallage S1, Yang T1, Lau CH1, Valbuena GN1, Keun HC1.
Journal of proteome research.J Proteome Res.2016 Aug 5;15(8):2618-25. doi: 10.1021/acs.jproteome.6b00188. Epub 2016 Jul 22.
Methylenetetrahydrofolate dehydrogenase (NAD(P)+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2) is a mitochondrial enzyme involved in folate metabolism. A number of recent studies have highlighted this enzyme as being highly expressed in many solid tumors, including breast cancer, an
PMID 27315223

Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.

Ganz AB1, Shields K1, Fomin VG1, Lopez YS1, Mohan S1, Lovesky J1, Chuang JC1, Ganti A1, Carrier B1, Yan J1, Taeswuan S1, Cohen VV1, Swersky CC1, Stover JA1, Vitiello GA1, Malysheva OV1, Mudrak E2, Caudill MA3.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2016 Jun 24. pii: fj.201500138RR. [Epub ahead of print]
Although single nucleotide polymorphisms (SNPs) in folate-mediated pathways predict susceptibility to choline deficiency during severe choline deprivation, it is unknown if effects persist at recommended intakes. Thus, we used stable isotope liquid chromatography-mass spectrometry/mass spectrometry
PMID 27342765

Groth M1, Moissiard G1, Wirtz M2, Wang H3, Garcia-Salinas C4, Ramos-Parra PA4, Bischof S1, Feng S1,5,6, Cokus SJ1, John A1, Smith DC1, Zhai J1, Hale CJ1, Long JA1, Hell R2, Díaz de la Garza RI4, Jacobsen SE1,5,6.
Nature communications.Nat Commun.2016 Jun 13;7:11640. doi: 10.1038/ncomms11640.
DNA methylation is an epigenetic mechanism that has important functions in transcriptional silencing and is associated with repressive histone methylation (H3K9me). To further investigate silencing mechanisms, we screened a mutagenized Arabidopsis thaliana population for expression of SDCpro-GFP, re
PMID 27291711

A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyl-tetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects. Report of the Birth Defects Research Group

Changes of Gene Expression by Lysophosphatidylcholine in Vascular Endothelial Cells: 12 Up-Regulated Distinct Genes Including 5 Cell Growth-Related, 3 Thrombosis-Related, and 4 Others.

Sato Naoaki,Kokame Koichi,Shimokado Kentaro,Kato Hisao,Miyata Toshiyuki
The Journal of Biochemistry 123(6), 1119-1126, 1998
… We identified 12 up-regulated distinct genes including 5 cell growth-related genes (two phosphatases CL100 and B23/hVH-3, graven, activating transcription factor-4, and heparin-binding epidermal growth factor-like growth factor), 3 thrombosis-related genes (plasminogen activator inhibitor-1, tissue plasminogen activator, and thrombomodulin), and 4 others (stanniocalcin, NAD-dependent methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, BENE, and reducing agents and tunicamycin-responsive protein). …
NAID 130003533478

鈴木襄
ビタミン 48(12), 521-537, 1974-12-25
… The enzymes detected were dihydrofolate reductase, formyltetrahydrofolate synthetase, methenyltetrahydrofolate cyclohydrolase, methylenetetrahydrofolate dehydrogenase, and 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide (AICA-ribotide) formyltransferase. … One is by catalytic action of formyltetrahydrofolate synthetase, and the other by methenyltetrahydrofolate cyclohydrolase and methylenetetrahydrofolate dehydrogenase. …
NAID 110002868481

methenyltetrahydrofolate cyclohydrolase
Identifiers
EC number	3.5.4.9
CAS number	9027-97-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search
PMC	articles
PubMed	articles
NCBI	proteins