カルボプラチン
WordNet
- a heavy precious metallic element; grey-white and resistant to corroding; occurs in some nickel and copper ores and is also found native in some deposits (同)Pt, atomic number 78
PrepTutorEJDIC
- プラチナ,白金(化学記号は『Pt』)
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Unprecedented water addition to the α,β-unsaturated enone bond, mediated by the combination of carbonate and platinum(II).
- Marqués-Gallego P, Reedijk J.SourceLeiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands.
- Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2010 Nov 15;16(43):12860-4.
- The cytostatic compounds cis-[Pt(A9pyp)(dmso)Cl(2)] (1) and [Pt(A9pyp)(dmso)(cbdca)] (2) (A9pyp=(E)-[1-(9-anthryl)-3-(2-pyridyl)-2-propenone) as carrier ligand; cbdca=cyclobutane dicarboxylate) have been found to add water across the enone C==C bond of the ligand A9pyp. The water addition occurs in
- PMID 20878801
- Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane-kappa 2N,N'] platinum(II) complexes.
- Liu W, Chen X, Xie M, Lou L, Ye Q, Yu Y, Hou S.SourcePlatinum-Based Drug Lab, Kunming Institute of Precious Metals, Kunming 650106, PR China. liuweiping0917@126.com
- Journal of inorganic biochemistry.J Inorg Biochem.2008 Oct;102(10):1942-6. Epub 2008 Jul 11.
- A series of novel platinum(II) complexes involving a carrier with HO- peripheral functional group, 2-hydroxy-1,3-propanediamine (HO-pda), cis-[Pt(HO-dpa)X(2)] (X(2)=2Cl(-) (1), C(2)O(4)(2-) (2), malonate (3), 1,1-cyclobutane dicarboxylate (CBDCA) (4), 3-hydroxy-1,1-cyclobutanedicarboxylate (HO-CBDCA
- PMID 18707762
Japanese Journal
- Cis-diammine-1, 1-cyclobutane dicarboxylate platinum (II) を用いた温熱化学療法に関する基礎的研究
- EXPERIMENTAL STUDIES ON THE PHARMACOKINETICS AND NEPHROTOXICITY OF CARBOPLATIN (CIS-DIAMMINE-1, 1-CYCLOBUTANE DICARBOXYLATE PLATINUM II) IN RATS
- Synthesis and Antitumor Activities of Alkyl-1,4-butanediamine Pt(II) Complexes Having Seven-Membered Ring Structure
★リンクテーブル★
[★]
- 英
- carboplatin
- 同
- シクロブタンジカルボン酸プラチナム cyclobutane dicarboxylate platinum CBDCA
- 商
- パラプラチン Paraplatin
- 関
- 抗腫瘍薬
特徴
作用機序
- DNA鎖内および鎖間架橋の形成によりDNA合成を阻害
適応
- 頭頸部癌、肺小細胞癌、精巣腫瘍、卵巣癌、子宮頸癌、悪性リンパ腫、非小細胞肺癌
- 以下の悪性腫瘍に対する他の抗悪性腫瘍剤との併用療法
- 小児悪性固形腫瘍(神経芽腫・網膜芽腫・肝芽腫・中枢神経系胚細胞腫瘍、再発又は難治性のユーイング肉腫・腎芽腫)
副作用
添付文書
http://www.info.pmda.go.jp/go/pack/4291403F1026_2_14/
http://www.info.pmda.go.jp/go/pack/4291403A1088_1_03/
[★]
ジカルボン酸、カルボン酸塩、ジカルボン酸エステル
- 関
- dicarboxylic acid