Thymic self-antigens for the design of a negative/tolerogenic self-vaccination against type 1 diabetes.
Geenen V1, Mottet M, Dardenne O, Kermani H, Martens H, Francois JM, Galleni M, Hober D, Rahmouni S, Moutschen M.
Current opinion in pharmacology.Curr Opin Pharmacol.2010 Aug;10(4):461-72. doi: 10.1016/j.coph.2010.04.005. Epub 2010 Apr 29.
Before being able to react against infectious nonself-antigens, the immune system has to be educated in the recognition and tolerance of neuroendocrine proteins and this critical process takes place only in the thymus. The development of the autoimmune diabetogenic response results from a thymus dys
Effect of acute and chronic alcohol abuse on pain management in a trauma center.
Askay SW1, Bombardier CH, Patterson DR.
Expert review of neurotherapeutics.Expert Rev Neurother.2009 Feb;9(2):271-7. doi: 10.1586/14737175.9.2.271.
The proper management of acute pain has been identified as a primary indicator of quality assurance in US trauma centers. Nearly half of all trauma patients are injured while intoxicated and 75% of these patients have chronic alcohol problems. The management of pain caused by injuries in patients wi
Nitrates such as nitroglycerin (GTN) and nitric oxide donors such as S-nitrosothiols are clinically vasoactive through stimulation of soluble guanylyl cyclase (sGC), which produces the second messenger cGMP. Development of nitrate tolerance, after exposure to GTN for several hours, is a major drawba
cross-tolerance / ˈkrɔsˈtɒl ər əns, ˈkrɒs-/ Show Spelled [kraws-tol-er-uh ns, kros-] Show IPA noun Physiology. the resistance to one or more effects of a substance because of tolerance to a pharmacologically similar substance: a ...
When Does Crosstolerance Occur? What Is Tolerance In Cross Country? When Does Crosstolerance Occur? What Two Drugs Are Cross Tolerant? What Are The Cross Streets And City Of The Museum Of Tolerance In California? ...