WordNet

cause to be constipated; "These foods tend to constipate you" (同)bind
irregular and infrequent or difficult evacuation of the bowels; can be a symptom of intestinal obstruction or diverticulitis (同)irregularity
severe constipation resulting from an obstruction in the intestines
not constipated (同)regular
have difficult or incomplete or infrequent evacuation of the bowels

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〈人〉'を'便秘させる
便秘

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1. 成人における慢性便秘のマネージメント management of chronic constipation in adults
2. 幼児および小児における急性便秘の予防および治療 prevention and treatment of acute constipation in infants and children
3. 乳児および小児における便秘：評価 constipation in infants and children evaluation
4. 高齢者における便秘 constipation in the older adult
5. 乳児および小児の機能性便秘：臨床的特徴と鑑別診断 functional constipation in infants and children clinical features and differential diagnosis

English Journal

Clinical profiles of Parkinson's disease associated with common leucine-rich repeat kinase 2 and glucocerebrosidase genetic variants in Chinese individuals.

Wang C, Cai Y, Gu Z, Ma J, Zheng Z, Tang BS, Xu Y, Zhou Y, Feng T, Wang T, Chen SD, Chan P; Chinese Parkinson Study Group.Author information Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China; Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China; Key Laboratory on Neurodegenerative Disease of Ministry of Education and Key Laboratory on Parkinson's Disease of Beijing, Beijing, China; Department of Neurology, The Affiliated Sanming First Hospital of Fujian Medical University, Sanming, Fujian, China.AbstractClinical profiles of Parkinson's disease (PD) related to LRRK2 (LRRK2-PD), and GBA (GBA-PD) genes have not been reported in Chinese individuals. In this study, we have investigated motor and non-motor aspects in 1638 Chinese PD patients who carried LRRK2 G2385R or R1628P (LRRK2-PD, n = 223), GBA L444P variant (GBA-PD, n = 49), or none of the variants (idiopathic PD [IPD], n = 1366). As a result, age at onset and motor and non-motor features of LRRK2-PD patients were similar to IPD patients except for milder non-motor symptoms. In contrast, GBA-PD patients had a significantly younger age at onset and higher Unified Parkinson's Disease Rating Scale scores than LRRK2-PD and IPD patients. In addition, postural instability and gait disorders, motor complications, cognitive decline, hallucination, sexual dysfunction, and constipation were more frequent in GBA-PD than in LRRK2-PD and IPD patients, and GBA-PD patients had a worse performance for social functioning and role-emotional scores. Our study represents the first large-scale clinical study of LRRK2-PD and GBA-PD in ethnic Chinese individuals. The data suggest that both LRRK2-PD and GBA-PD are similar to IPD, except for an earlier age at onset and relatively more common non-motor symptoms in GBA-PD patients. These findings strengthen our understanding of the clinical heterogeneity of PD, and may have implications for molecular classification of the disease.
Neurobiology of aging.Neurobiol Aging.2014 Mar;35(3):725.e1-6. doi: 10.1016/j.neurobiolaging.2013.08.012. Epub 2013 Oct 3.
Clinical profiles of Parkinson's disease (PD) related to LRRK2 (LRRK2-PD), and GBA (GBA-PD) genes have not been reported in Chinese individuals. In this study, we have investigated motor and non-motor aspects in 1638 Chinese PD patients who carried LRRK2 G2385R or R1628P (LRRK2-PD, n = 223), GBA L4
PMID 24095219

Constipation: understanding mechanisms and management.

Costilla VC, Foxx-Orenstein AE.Author information Department of Internal Medicine, Mayo Clinic in Arizona, Scottsdale, AZ, USA.AbstractConstipation is a frequently diagnosed gastrointestinal disorder. Symptoms of constipation are common, with the greatest prevalence in the elderly. Evaluation of constipation begins with a detailed medical history and a focused anorectal examination. Diagnostic testing for constipation is not routinely recommended in the initial evaluation in the absence of alarm signs. Key self-management strategies include increased exercise, a high-fiber diet, and toilet training. High-fiber diets can worsen symptoms in some patients who have chronic constipation. Biofeedback is an effective treatment option for patients who have constipation caused by outlet obstruction defecation. A variety of medications are available to remedy constipation.
Clinics in geriatric medicine.Clin Geriatr Med.2014 Feb;30(1):107-15. doi: 10.1016/j.cger.2013.10.001.
Constipation is a frequently diagnosed gastrointestinal disorder. Symptoms of constipation are common, with the greatest prevalence in the elderly. Evaluation of constipation begins with a detailed medical history and a focused anorectal examination. Diagnostic testing for constipation is not routin
PMID 24267606

Anorectal physiology and pathophysiology in the elderly.

Yu SW, Rao SS.Author information Division of Gastroenterology and Hepatology, Medical College of Georgia, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, USA.AbstractAnorectal medical disorders facing the elderly include fecal incontinence, fecal impaction with overflow fecal incontinence, chronic constipation, dyssynergic defecation, hemorrhoids, anal fissure, and pelvic floor disorders. This article discusses the latest advances in age-related changes in morphology and function of anal sphincter, changes in cellular and molecular biology, alterations in neurotransmitters and reflexes, and their impact on functional changes of the anorectum in the elderly. These biophysiologic changes have implications for the pathophysiology of anorectal disorders. A clear understanding and working knowledge of the functional anatomy and pathophysiology will enable appropriate diagnosis and treatment of these disorders.
Clinics in geriatric medicine.Clin Geriatr Med.2014 Feb;30(1):95-106. doi: 10.1016/j.cger.2013.10.003.
Anorectal medical disorders facing the elderly include fecal incontinence, fecal impaction with overflow fecal incontinence, chronic constipation, dyssynergic defecation, hemorrhoids, anal fissure, and pelvic floor disorders. This article discusses the latest advances in age-related changes in morph
PMID 24267605

Japanese Journal

ヒトの排便に及ぼす難消化性デキストリン含有クッキー摂取の影響

日本食物繊維研究会誌 3(2), 79-83, 1999
NAID 130004325834

青年期女性の排便習慣に対する小麦ふすまシリアルの改善効果

日本食物繊維研究会誌 1(2), 15-22, 1998
NAID 130004325811

A^G-β-D-Galactosylsucroseが女性の便通および便性改善に及ぼす影響

日本食品化学学会誌 1(1), 39-45, 1995-03-28
NAID 110007367070

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