coactivator function

• コアクチベーター機能、活性化補助因子機能

WordNet

1. perform as expected when applied; "The washing machine wont go unless its plugged in"; "Does this old car still run well?"; "This old radio doesnt work anymore" (同)work, operate, go, run
2. (mathematics) a mathematical relation such that each element of a given set (the domain of the function) is associated with an element of another set (the range of the function) (同)mathematical function, single-valued function, map, mapping
3. a relation such that one thing is dependent on another; "height is a function of age"; "price is a function of supply and demand"
4. the actions and activities assigned to or required or expected of a person or group; "the function of a teacher"; "the government must do its part"; "play its role" (同)office, part, role
5. what something is used for; "the function of an auger is to bore holes"; "ballet is beautiful but what use is it?" (同)purpose, role, use
6. a formal or official social gathering or ceremony; "it was a black-tie function"
7. performing or able to perform its regular function; "a functioning flashlight"

PrepTutorEJDIC

1. (人・物の果たすべき)『働き』,機能,役目;《しばしば複数形で》職務 / (公式の)儀式,《話》大きな催し(集まり),式典 / (数学で)関数 / 〈機械などが〉『機能を果たす』,動く / (…の)役目をする,代用となる《+『as』+『名』》

UpToDate Contents

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• 1. 選択的エストロゲン受容体モジュレーターの作用機序 mechanisms of action of selective estrogen receptor modulators
• 2. 甲状腺ホルモンの作用 thyroid hormone action
• 3. プロゲステロン受容体モジュレーター（PRM）の薬理学および作用機序 pharmacology and mechanism of action of progesterone receptor modulators prms
• 4. 正常な加齢 normal aging
• 5. Pathogenesis and clinical manifestations of disorders of androgen action

English Journal

• The role of aberrant mitochondrial bioenergetics in diabetic neuropathy.

• Chowdhury SK, Smith DR, Fernyhough P.SourceDivision of Neurodegenerative Disorders, St Boniface Hospital Research Centre, Winnipeg, MB, Canada.
• Neurobiology of disease.Neurobiol Dis.2013 Mar;51:56-65. doi: 10.1016/j.nbd.2012.03.016. Epub 2012 Mar 9.
• Diabetic neuropathy is a neurological complication of diabetes that causes significant morbidity and, because of the obesity-driven rise in incidence of type 2 diabetes, is becoming a major international health problem. Mitochondrial phenotype is abnormal in sensory neurons in diabetes and may contr
• PMID 22446165

• Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production.

• Charles AL, Meyer A, Dal-Ros S, Auger C, Keller N, Ramamoorthy TG, Zoll J, Metzger D, Schini-Kerth V, Geny B.SourceB. Geny: Service de Physiologie et d'Explorations Fonctionnelles et Equipe d'Accueil 3072, Université et Hôpitaux Universitaires de Strasbourg - 67091 Strasbourg, France. bernard.geny@chru-strasbourg.fr.
• Experimental physiology.Exp Physiol.2013 Feb;98(2):536-45. doi: 10.1113/expphysiol.2012.067496. Epub 2012 Aug 17.
• Ageing is associated with skeletal muscle impairment. Changes in mitochondrial homeostasis are thought to play a key role in this process. This study examined whether chronic intake of polyphenols (PPs), which are known to be modulators of oxidative stress, might prevent the age-related decline of m
• PMID 22903980

• The effect of overexpression of PGC-1α on the mtDNA4834 common deletion in a rat cochlear marginal cell senescence model.

• Zhao XY, Sun JL, Hu YJ, Yang Y, Zhang WJ, Hu Y, Li J, Sun Y, Zhong Y, Peng W, Zhang HL, Kong WJ.SourceDepartment of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China.
• Hearing research.Hear Res.2013 Feb;296:13-24. doi: 10.1016/j.heares.2012.11.007. Epub 2012 Nov 16.
• Aging is a natural process usually defined as a progressive loss of function with an accumulation of senescent cells. The clinical manifestations of this process include age-related hearing loss (AHL)/presbycusis. Several investigations indicated the association between a mitochondrial common deleti
• PMID 23159434

Japanese Journal

• Change in PGC-1α Expression in Rat Skeletal Muscle after Low-intensity Prolonged Swimming Exercise

• FUJIMOTO Eri,YAMAGUCHI Wataru,TERADA Shin,HIGUCHI Mitsuru,TABATA Izumi
• Journal of physiological anthropology 30(1), 23-27, 2011-01-31
• … After 6-h low-intensity swimming exercise (LIE), peroxisome proliferator-activated receptor γ coactivator -1α (PGC-1α) in whole and nuclear fractions in rat skeletal muscle was higher than the control rats' muscles up to 18 h after LIE. … Furthermore, we evaluated change in the mRNA of δ-aminolevulinate synthase (ALAS), a mitochondrial protein, to clarify in which fraction of PGC-1α has a physiological role as a transcriptional coactivator for enhancing the mitochondrial oxidative enzymes after exercise. …
• NAID 10027419011

• Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription

• Furumatsu Takayuki,Shukunami Chisa,Amemiya-Kudo Michiyo,Shimano Hitoshi,Ozaki Toshifumi
• The International Journal of Biochemistry & Cell Biology 42(1), 148-156, 2010-01-00
• … In this study, we investigated the function of Scx in the Sox9-dependent transcription. … Coactivator p300 synergistically increased the activity of Sox9-regulated reporter gene, which contains promoter and enhancer regions of Col2a1, in the presence of Scx and E47. …
• NAID 120003338814

• Effects of Chitooligosaccharide Lactate Salt on Sleep Deprivation-Induced Fatigue in Mice

• Cho Si Young,Lee Ji Hae,Song Min Jeong [他],Park Pil Joon,Shin Eui Seok,Sohn Jong Hee,Seo Dae-Bang,Lim Kyung Min,Kim Wan Gi,Lee Sang-Jun
• Biological and Pharmaceutical Bulletin 33(7), 1128-1132, 2010
• … Of particular note, the oral administration of COS lactate increased the mitochondrial membrane potential and the mitochondrial number significantly, indicating that COS lactate may enhance mitochondrial function. … In support of this, COS lactate increased the expression of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and cytochrome c (Cyt C) mRNA, indicating that it may increase mitochondrial biogenesis. …
• NAID 130000300275

Related Links

• Coactivator Function of Positive Cofactor 4 (PC4) in Sp1 ...

In this study, we investigated PC4 coactivator function in the control of LHR transcription. Knockdown of PC4 by siRNA inhibited the LHR basal promoter activity and trichostatin A (TSA)-induced gene transcriptional Sp1 2 is a ...

• Function - neXtProt - exploring the universe of human proteins

NX_Q15596 - Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance ...

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★リンクテーブル★

リンク元	「活性化補助因子機能」「コアクチベーター機能」
関連記事	「function」

「活性化補助因子機能」

　　[★]

英

coactivator function

関

コアクチベーター機能

「コアクチベーター機能」

　　[★]

英

coactivator function

関

活性化補助因子機能

「function」

　　[★]

• n.

• 機能、(数学)関数、(化学)官能基

survival as a function of HbA1c in people with type 2 diabetes HbA1cの機能を考慮（指標に）した2型糖尿病の患者の生存（予後）

Figure 2A shows survival as a function of device removal during index hpspitalization, censored at 1 year or date of last contact. (Figure2Aはは最初の入院中における心臓デバイス除去に関する生存曲線で退院後1年もしくは最後の接触で打ち切っている)

• v.

• 機能する

関

functional、functional group、functionalise、functionalize、operate