関: chloroperoxidase

WordNet

any compound containing a chlorine atom
any salt of hydrochloric acid (containing the chloride ion)
any of a group of enzymes (occurring especially in plant cells) that catalyze the oxidation of a compound by a peroxide

PrepTutorEJDIC

塩化物

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/05 09:27:59」(JST)

wiki en

Chloride peroxidase (EC 1.11.1.10) is a family of enzymes that catalyzs the chlorination of organic compounds. This enzyme combines the inorganic substrates chloride and hydrogen peroxide to produce the equivalent of Cl⁺, which replaces a proton in hydrocarbon substrate:

R-H + Cl^- + H₂O₂ + H⁺ → R-Cl + 2 H₂O

Many organochlorine compounds are biosynthesized in this way.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is chloride:hydrogen-peroxide oxidoreductase. This enzyme is also called chloroperoxidase. It employs one cofactor which may be either heme or vanadium.^[1]

The heme-containing chloroperoxidase (CPO) exhibits peroxidase, catalase and cytochrome P450-like activities in addition to catalyzing halogenation reactions.^[2] Despite functional similarities with other heme enzymes, the structure of CPO is unique, which folds into a tertiary structure dominated by eight helical segments. The catalytic acid base, required to cleave the peroxide O-O bond, is glutamic acid rather than histidine as in horseradish peroxidase.

Structural studies

As of late 2007, 30 structures have been solved for this class of enzymes, with PDB accession codes 1A7U, 1A88, 1A8Q, 1A8S, 1A8U, 1BRT, 1CPO, 1IDQ, 1IDU, 1QHB, 1QI9, 1VNC, 1VNE, 1VNF, 1VNG, 1VNH, 1VNI, 1VNS, 2CIV, 2CIW, 2CIX, 2CIY, 2CIZ, 2CJ0, 2CJ1, 2CJ2, 2CPO, 2J18, 2J19, and 2J5M.

References

^ Butler, Alison; Carter-Franklin, Jayme N. (2004). "The role of vanadium bromoperoxidase in the biosynthesis of halogenated marine natural products". Natural Product Reports 21 (1): 180–8. doi:10.1039/b302337k. PMID 15039842. Cite uses deprecated parameters (help) (this paper also discussed chloroperoxidases.
^ Poulos TL, Sundaramoorthy M, Terner J (1995). "The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid". Structure 3 (12): 1367–1377. doi:10.1016/S0969-2126(01)00274-X. PMID 8747463.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 薬物乱用検査（DOA） testing for drugs of abuse doa
2. 妊娠中の甲状腺機能低下症：臨床症状、診断、および治療 hypothyroidism during pregnancy clinical manifestations diagnosis and treatment
3. 妊娠中の甲状腺疾患の概要 overview of thyroid disease in pregnancy
4. 橋本病（慢性自己免疫性甲状腺炎）の病因 pathogenesis of hashimotos thyroiditis chronic autoimmune thyroiditis
5. 妊娠していない成人における甲状腺機能低下症の診断およびスクリーニング diagnosis of and screening for hypothyroidism in nonpregnant adults

English Journal

Lanthanum ions intervened in enzymatic production and elimination of reactive oxygen species in leaves of rice seedlings under cadmium stress.

Wang CR1, Wang QY, Tian Y, Zhang JF, Li ZX, Cao P, Zhu M, Li TT.
Environmental toxicology and chemistry / SETAC.Environ Toxicol Chem.2014 Jul;33(7):1656-64. doi: 10.1002/etc.2610. Epub 2014 May 27.
Rare earth elements at proper concentrations were observed to alleviate heavy metal stress. However, the potential mechanisms of alleviation are not clear. Thus, the present study focused on the mechanisms of lanthanum (La) ions on the generation and elimination of reactive oxygen species (ROS) prod
PMID 24753051

The potential effect of berberine in mercury-induced hepatorenal toxicity in albino rats.

Othman MS1, Safwat G1, Aboulkhair M1, Abdel Moneim AE2.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2014 Jul;69:175-81. doi: 10.1016/j.fct.2014.04.012. Epub 2014 Apr 18.
Mercury (Hg) is the third most dangerous heavy metal after arsenic and lead. Mercury's toxicity brings serious risks to health through negative pathological and biochemical effects. The study was designed to investigate the possible protective role of berberine (BN) in mercuric chloride (HgCl2) indu
PMID 24751971

Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.

Phuan PW1, Veit G1, Tan J1, Roldan A1, Finkbeiner WE1, Lukacs GL1, Verkman AS2.
Molecular pharmacology.Mol Pharmacol.2014 Jul;86(1):42-51. doi: 10.1124/mol.114.092478. Epub 2014 Apr 15.
The most prevalent cystic fibrosis transmembrane conductance regulator (CFTR) mutation causing cystic fibrosis, ΔF508, impairs folding of nucleotide binding domain (NBD) 1 and stability of the interface between NBD1 and the membrane-spanning domains. The interfacial stability defect can be partiall
PMID 24737137