Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells.
Guo XL, Li D, Hu F, Song JR, Zhang SS, Deng WJ, Sun K, Zhao QD, Xie XQ, Song YJ, Wu MC, Wei LX.SourceTumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, PR China.
Cancer letters.Cancer Lett.2012 Jul 28;320(2):171-9. Epub 2012 Mar 8.
Induction of cell death and inhibition of cell growth are the main targets of cancer therapy. Here we evaluated the role of autophagy on chemoresistance of human hepatocarcinoma (HCC) cell lines, focusing on its crosstalk with cell apoptosis and proliferation. In this study, a chemotherapeutic agent
Luteolin induces apoptosis in multidrug resistant cancer cells without affecting the drug transporter function: involvement of cell line-specific apoptotic mechanisms.
Rao PS, Satelli A, Moridani M, Jenkins M, Rao US.SourceDepartment of Biomedical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
International journal of cancer. Journal international du cancer.Int J Cancer.2012 Jun 1;130(11):2703-14. doi: 10.1002/ijc.26308. Epub 2011 Aug 25.
Bioflavonoids are of considerable interest to human health as these serve as antioxidant and anticancer agents. Although epidemiological and experimental studies suggest that luteolin, a natural bioflavonoid, exhibits chemopreventive properties, its effectiveness as an antiproliferative agent agains
… A number of studies on the mechanism of uncoupler action appear to be incompatible with the chemiosmotic hypothesis which assumes that bulk proton electrochemical gradient (Δμ^^〜_H) is the only intermediate linking between oxidation and phosphotylation in mitochondria. …
Chemiosmosis is the movement of ions across a selectively permeable membrane, down their electrochemical gradient. .... "Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism". Nature 191 ...
Animation. Conclusion. Quiz. Two Experiments Demonstrate the Chemiosmotic Mechanism. pH4 ... the mechanism of action of ATP synthase. Previous. Next. 1 of 3. The chemiosmotic mechanism has three parts: 1. Food molecules supply the ...