関: cepharanthin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/18 14:27:45」(JST)

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Cepharanthine is an antiinflammatory and antineoplastic compound isolated from Stephania.^[1] Due to these modalities, it has been shown effective against HTLV in lab research. ^[2] Additionally, it has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported. ^[3]

References

^ Huang, H.; Hu, G.; Wang, C.; Xu, H.; Chen, X.; Qian, A. (2013). "Cepharanthine, an Alkaloid from Stephania cepharantha Hayata, Inhibits the Inflammatory Response in the RAW264.7 Cell and Mouse Models". Inflammation 37 (1): 235–46. doi:10.1007/s10753-013-9734-8. PMID 24045962.
^ Synergistic inhibition of HTLV-1-infected cell proliferation by combination of cepharanthine and a tetramethylnaphthalene derivative.
^ Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions.

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1. 男性における男性型脱毛症の治療 treatment of androgenetic alopecia in men

English Journal

Genetic Variants of ABCC10, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction.

Pushpakom SP, Liptrott NJ, Rodriguez-Novoa S, Labarga P, Soriano V, Albalater M, Hopper-Borge E, Bonora S, Di Perri G, Back DJ, Khoo S, Pirmohamed M, Owen A.SourceNational Institute for Health Research Biomedical Research Centre, Royal Liverpool Hospital.
The Journal of infectious diseases.2011 Jul;204(1):145-53.
Background.?Tenofovir (TFV) causes kidney tubular dysfunction (KTD) in some patients, but the mechanism is poorly understood. Genetic variants in TFV transporters are implicated; we explored whether ABCC10 transports TFV and whether ABCC10 single-nucleotide polymorphisms (SNPs) are associated with
PMID 21628669

PMID 21602589

Japanese Journal

Cepharanthine exerts antitumor activity on cholangiocarcinoma by inhibiting NF-κB

SEUBWAI Wunchana,VAETEEWOOTTACHARN Kulthida,HIYOSHI Masateru,SUZU Shinya,PUAPAIROJ Anucha,WONGKHAM Chairisi,OKADA Seiji,WONGKHAM Sopit
Cancer science 101(7), 1590-1595, 2010-07-10
NAID 10026594375

TPFL-セファランチン療法に放射線治療を併用し, 著効を得た顎下腺原発扁平上皮癌の胸鎖関節部転移の1例

和田健,中谷現,根来健二,平石幸裕,薮田達雄,東條格,藤田茂之
頭頸部癌/ 日本頭頸部癌学会 33(3), 380-384, 2007-10-25
NAID 10019776042

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「セファランチン」

Cepharanthine
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
ATC code	none
PubChem	CID 10206
ChemSpider	9791
ChEMBL	CHEMBL449782
Synonyms	Cepharantin, O-Methylcepharanoline
Chemical data
Formula	C37H38N2O6
Molar mass	606.70742 g/mol
	SMILES CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3 ;
	InChI InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1 ; Key:YVPXVXANRNDGTA-WDYNHAJCSA-N ;

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英: cepharanthin、cepharanthine
商: セファランチン

[1] Huang, H.; Hu, G.; Wang, C.; Xu, H.; Chen, X.; Qian, A. (2013). "Cepharanthine, an Alkaloid from Stephania cepharantha Hayata, Inhibits the Inflammatory Response in the RAW264.7 Cell and Mouse Models". Inflammation 37 (1): 235–46. doi:10.1007/s10753-013-9734-8. PMID 24045962.

[2] Synergistic inhibition of HTLV-1-infected cell proliferation by combination of cepharanthine and a tetramethylnaphthalene derivative.

[3] Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions.

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cepharanthine