centromere protein B

セントロメアタンパク質B

関

CENP-B

WordNet

1. the 2nd letter of the Roman alphabet (同)b
2. the blood group whose red cells carry the B antigen (同)type_B, group B
3. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
4. a specialized condensed region of each chromosome that appears during mitosis where the chromatids are held together to form an X shape; "the centromere is difficult to sequence" (同)kinetochore

PrepTutorEJDIC

1. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/04 19:13:42」(JST)

wiki en

[Wiki en表示]

Centromere protein B, 80kDa
PDB rendering based on 1bw6.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1BW6, 1HLV, 1UFI
Identifiers
Symbol	CENPB
External IDs	OMIM: 117140 MGI: 88376 HomoloGene: 1370 GeneCards: CENPB Gene
Gene ontology Molecular function • chromatin binding • satellite DNA binding • centromeric DNA binding • sequence-specific DNA binding Cellular component • chromosome, centromeric region • nucleus Biological process • regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1059	12616
Ensembl	ENSG00000125817	ENSMUSG00000068267
UniProt	P07199	P27790
RefSeq (mRNA)	NM_001810	NM_007682
RefSeq (protein)	NP_001801	NP_031708
Location (UCSC)	Chr 20: 3.76 – 3.77 Mb	Chr 2: 131.18 – 131.18 Mb
PubMed search	[1]	[2]

Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene.

Function

Centromere protein B is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

Clinical significance

Centromere protein B is a potential biomarker of small-cell lung cancer.

See also

• Centromere

References

Further reading

• Saxena A; Wong LH; Kalitsis P et al. (2002). "Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc". Hum. Mol. Genet. 11 (19): 2319–29. doi:10.1093/hmg/11.19.2319. PMID 12217960. 
• Nousiainen M; Silljé HH; Sauer G et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. 
• Orthaus S; Biskup C; Hoffmann B et al. (2008). "Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells". Chembiochem 9 (1): 77–92. doi:10.1002/cbic.200700358. PMID 18072184. 
• Tawaramoto MS; Park SY; Tanaka Y et al. (2003). "Crystal structure of the human centromere protein B (CENP-B) dimerization domain at 1.65-A resolution". J. Biol. Chem. 278 (51): 51454–61. doi:10.1074/jbc.M310388200. PMID 14522975. 
• Tanaka Y; Tachiwana H; Yoda K et al. (2005). "Human centromere protein B induces translational positioning of nucleosomes on alpha-satellite sequences". J. Biol. Chem. 280 (50): 41609–18. doi:10.1074/jbc.M509666200. PMID 16183641. 
• Wellcome Trust Case Control Consortium; Clayton, David G.; Cardon, Lon R.; Craddock, Nick; Deloukas, Panos; Duncanson, Audrey; Kwiatkowski, Dominic P.; McCarthy, Mark I. et al. (2007). "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature 447 (7145): 661–78. doi:10.1038/nature05911. PMC 2719288. PMID 17554300. 
• Tanaka Y, Kurumizaka H, Yokoyama S (2005). "CpG methylation of the CENP-B box reduces human CENP-B binding". FEBS J. 272 (1): 282–9. doi:10.1111/j.1432-1033.2004.04406.x. PMID 15634350. 
• Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the Human Deubiquitinating Enzyme Interaction Landscape". Cell 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732. 
• Lim J; Hao T; Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
• Lomonte P, Morency E (2007). "Centromeric protein CENP-B proteasomal degradation induced by the viral protein ICP0". FEBS Lett. 581 (4): 658–62. doi:10.1016/j.febslet.2007.01.027. PMID 17258208. 
• Suzuki N; Nakano M; Nozaki N et al. (2004). "CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization". J. Biol. Chem. 279 (7): 5934–46. doi:10.1074/jbc.M306477200. PMID 14612452. 
• Hellwig D; Münch S; Orthaus S et al. (2008). "Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B". J Biophotonics 1 (3): 245–54. doi:10.1002/jbio.200810014. PMID 19412974. 
• Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Robitaille G; Hénault J; Christin MS et al. (2007). "The nuclear autoantigen CENP-B displays cytokine-like activities toward vascular smooth muscle cells". Arthritis Rheum. 56 (11): 3814–26. doi:10.1002/art.22972. PMID 17968937. 
• Obuse C; Yang H; Nozaki N et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. 
• Perdoni F; Bottone MG; Soldani C et al. (2009). "Distribution of centromeric proteins and PARP-1 during mitosis and apoptosis". Ann. N. Y. Acad. Sci. 1171: 32–7. doi:10.1111/j.1749-6632.2009.04729.x. PMID 19723035. 
• Andersen JS; Lam YW; Leung AK et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Robitaille G; Christin MS; Clément I et al. (2009). "Nuclear autoantigen CENP-B transactivation of the epidermal growth factor receptor via chemokine receptor 3 in vascular smooth muscle cells". Arthritis Rheum. 60 (9): 2805–16. doi:10.1002/art.24765. PMID 19714638. 

External links

• Centromere protein B at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 成人における全身性硬化症（強皮症）の診断および鑑別診断 diagnosis and differential diagnosis of systemic sclerosis scleroderma in adults
• 2. 抗核抗体染色パターンおよび関連自己抗体の臨床的意義 clinical significance of antinuclear antibody staining patterns and associated autoantibodies
• 3. 未分化型の全身性リウマチ性（結合組織）疾患およびオーバーラップ症候群 undifferentiated systemic rheumatic connective tissue diseases and overlap syndromes
• 4. シェーグレン症候群の臨床症状：腺外型疾患 clinical manifestations of sjogrens syndrome extraglandular disease
• 5. 全身性硬化症（強皮症）の病因 pathogenesis of systemic sclerosis scleroderma

English Journal

• Nap1 regulates proper CENP-B binding to nucleosomes.

• Tachiwana H, Miya Y, Shono N, Ohzeki J, Osakabe A, Otake K, Larionov V, Earnshaw WC, Kimura H, Masumoto H, Kurumizaka H.SourceLaboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo 162-8480, Japan.
• Nucleic acids research.Nucleic Acids Res.2013 Mar 1;41(5):2869-80. doi: 10.1093/nar/gks1464. Epub 2013 Jan 15.
• CENP-B is a widely conserved centromeric satellite DNA-binding protein, which specifically binds to a 17-bp DNA sequence known as the CENP-B box. CENP-B functions positively in the de novo assembly of centromeric nucleosomes, containing the centromere-specific histone H3 variant, CENP-A. At the same
• PMID 23325853

• CENP-B cooperates with Set1 in bidirectional transcriptional silencing and genome organization of retrotransposons.

• Lorenz DR, Mikheyeva IV, Johansen P, Meyer L, Berg A, Grewal SI, Cam HP.SourceBoston College, Biology Department, Chestnut Hill, Massachusetts, USA.
• Molecular and cellular biology.Mol Cell Biol.2012 Oct;32(20):4215-25. Epub 2012 Aug 20.
• Regulation of transposable elements (TEs) is critical to the integrity of the host genome. The fission yeast Schizosaccharomyces pombe homologs of mammalian CENP-B perform a host genome surveillance role by controlling Tf2 long terminal repeat (LTR) retrotransposons. However, the mechanisms by which
• PMID 22907751

• Fluoroenzymeimmunoassay to detect systemic sclerosis-associated antibodies: diagnostic performance and correlation with conventional techniques.

• Bonroy C, Smith V, Van Steendam K, Van Praet J, Deforce D, Devreese K, De Keyser F.SourceDepartment of Clinical Chemistry, Ghent University Hospital, Ghent, Belgium. carolien.bonroy@uzgent.be
• Clinical and experimental rheumatology.Clin Exp Rheumatol.2012 Sep-Oct;30(5):748-55. Epub 2012 Oct 17.
• OBJECTIVES: Detection of systemic sclerosis-associated antibodies (SSc-Ab) in routine clinical practice is mostly restricted to anti-centromere and anti-Scl-70 antibodies. However, also other antinuclear antibodies have been shown to be valuable diagnostic and prognostic markers for the disease. The
• PMID 22765957

Japanese Journal

• Visualization of specific repetitive genomic sequences with fluorescent TALEs in Arabidopsis thaliana

• Journal of Experimental Botany 67(21), 6101-6110, 2016-10-06
• NAID 120005890331

• CENP-B box が新世界ザルではセントロメア反復配列の異なる多くの場所に生じている

• Scientific Reports 6, 2016-06-13
• NAID 120005818231

• 生きたヒトHT1080細胞での細胞周期を通したCENP-AとPCNAの分子動態

• Molecular Biology Journals 5(2), 1000160-1000160, 2016
• NAID 120005960917

Related Links

• Centromere protein B - Wikipedia, the free encyclopedia

Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene. Contents. 1 Function; 2 Clinical significance; 3 See also ...

---

★リンクテーブル★

リンク元	「CENP-B」「セントロメアタンパク質B」
関連記事	「B」

「CENP-B」

　　[★]

• セントロメアタンパク質B

関

centromere protein B

「セントロメアタンパク質B」

　　[★]

英

centromere protein B、CENP-B

「B」

　　[★]

• 気管分岐部下緑
• 補体のalternative pathwayに関わる蛋白質

• Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する