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1. 腎疾患におけるカルニチン代謝と透析 carnitine metabolism in renal disease and dialysis
2. 代謝性ミオパチーの原因 causes of metabolic myopathies
3. 肝性脳症の治療 treatment of hepatic encephalopathy
4. 新生児における筋緊張低下を引き起こす末梢神経および筋肉の障害に関する概要 overview of peripheral nerve and muscle disorders causing hypotonia in the newborn
5. 透析患者における赤血球造血刺激因子製剤に対する非鉄薬理学的補助 non iron pharmacologic adjuvants to erythropoiesis stimulating agent therapy in dialysis patients

Novel c.2216T > C (p.I739T) Mutation in Exon 13 and c.1481T > A (p.L494X) Mutation in Exon 8 of MUT Gene in a Female with Methylmalonic Acidemia.

Imataka G, Sakamoto O, Yamanouchi H, Yoshihara S, Omura-Hasegawa Y, Tajima G, Arisaka O.SourceDepartment of Pediatrics, School of Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi, 321-0293, Japan, geo@dokkyomed.ac.jp.
Cell biochemistry and biophysics.Cell Biochem Biophys.2013 Mar 12. [Epub ahead of print]
We report herein a 1.5-year-old girl with methylmalonic acidemia (MMA) in whom two missense mutations were found: a novel I739T mutation located in exon 13 and the L494X mutation in exon 8. The results of organic acid test showed a pronounced increase in methylmalonate excretion with increased methy
PMID 23479330

Osmotic control of opuA expression in Bacillus subtilis and its modulation in response to intracellular glycine betaine and proline pools.

Hoffmann T, Wensing A, Brosius M, Steil L, Völker U, Bremer E.SourcePhilipps-University Marburg, Department of Biology, Laboratory for Microbiology, Marburg, Germany.
Journal of bacteriology.J Bacteriol.2013 Feb;195(3):510-22. doi: 10.1128/JB.01505-12. Epub 2012 Nov 21.
Glycine betaine is an effective osmoprotectant for Bacillus subtilis. Its import into osmotically stressed cells led to the buildup of large pools, whose size was sensitively determined by the degree of the osmotic stress imposed. The amassing of glycine betaine caused repression of the formation of
PMID 23175650

山田博明,弘中豊,濱堯夫
藥學雜誌 110(3), 225-234, 1990-03-25
… The effects of levocarnitine chloride [LC-80,(-)-(R)-(3-carboxy-2-hydroxypropyl)-trimethylammonium chloride] on the oxidation of [U-^<14>C] palmitate, [U-^<14>C] glucose and [2-^3H] glucose under hypoxic conditions in homogenates from the rat heart were investigated. …
NAID 110003649999

藤澤茂樹,立川信成,村上英司,増田匡志,水谷貞文,水谷真理,広瀬幸弘,山田博明,藤田和彦,長谷部徒公子,林ひろみ,八十百合子,弘中豊,河口直正,大西俊造
日本薬理学雑誌 96(5), 227-242, 1990
… まで持続投与した．心臓を摘出する直前v左心房よりThioflavin S(TS)を注入するin vivo法および摘出した心臓をMonastral blue(MB)で灌流するin vitro法によって冠血流遮断領域(リスク領域)を，また2，3，5-triphenyltetrazolium chloride(TTC)で染色する方法によって梗塞領域を測定した．これら3種類の色素による染色の有無によって，冠血流非遮断領域で正常な心筋細胞の存在するゾーン1，冠血流遮断領域(リスク領域)で側副血行路からの血 …
NAID 130000758989