WordNet

the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/04 20:42:49」(JST)

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Carboxypeptidase B (EC 3.4.17.2, protaminase, pancreatic carboxypeptidase B, tissue carboxypeptidase B, peptidyl-L-lysine [L-arginine]hydrolase) is a carboxypeptidase that preferentially acts upon basic amino acids, such as arginine and lysine.^[1]^[2]^[3]^[4] This serum enzyme is also responsible for rapidly metabolizing the C5a protein into C5a des-Arg, with one less amino acid.

References

^ Folk, J.E. (1970). "Carboxypeptidase B (porcine pancreas)". Methods Enzymol. 19: 504–508. doi:10.1016/0076-6879(70)19036-7.
^ Brodrick, J.W., Geokas, M.C. and Largman, C. (1976). "Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion". Biochim. Biophys. Acta 452: 468–481. doi:10.1016/0005-2744(76)90197-2. PMID 1009123.
^ Butterworth, J. and Duncan, J.J. (1979). "Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis". Clin. Chim. Acta 97: 39–43. doi:10.1016/0009-8981(79)90023-8. PMID 40714.
^ Wallace, E.F., Evans, C.J., Jurik, S.M., Mefford, I.N. and Barchas, J.D. (1982). "Carboxypeptidase B activity from adrenal medulla. Is it involved in the processing of proenkephalin?". Life Sci. 31: 1793–1796. doi:10.1016/0024-3205(82)90212-0. PMID 6130442.

External links

The MEROPS online database for peptidases and their inhibitors: M14.003
Carboxypeptidase B at the US National Library of Medicine Medical Subject Headings (MeSH)

Molecular and Cellular Biology portal

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「B」

carboxypeptidase B
Identifiers
EC number	3.4.17.2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search
PMC	articles
PubMed	articles
NCBI	proteins

carboxypeptidase B2 (plasma)
Identifiers
Symbol	CPB2
Entrez	1361
HUGO	2300
OMIM	603101
RefSeq	NM_016413
UniProt	Q96IY4
Other data
Locus	Chr. 13 q14.11

carboxypeptidase B1 (tissue)
Identifiers
Symbol	CPB1
Entrez	1360
HUGO	2299
OMIM	114852
RefSeq	NM_001871
UniProt	P15086
Other data
EC number	3.4.17.2
Locus	Chr. 3 q24

　　[★]

気管分岐部下緑
補体のalternative pathwayに関わる蛋白質

Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

「carboxypeptidase」

　　[★]

カルボキシペプチダーゼ

[1] Folk, J.E. (1970). "Carboxypeptidase B (porcine pancreas)". Methods Enzymol. 19: 504–508. doi:10.1016/0076-6879(70)19036-7.

[2] Brodrick, J.W., Geokas, M.C. and Largman, C. (1976). "Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion". Biochim. Biophys. Acta 452: 468–481. doi:10.1016/0005-2744(76)90197-2. PMID 1009123.

[3] Butterworth, J. and Duncan, J.J. (1979). "Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis". Clin. Chim. Acta 97: 39–43. doi:10.1016/0009-8981(79)90023-8. PMID 40714.

[4] Wallace, E.F., Evans, C.J., Jurik, S.M., Mefford, I.N. and Barchas, J.D. (1982). "Carboxypeptidase B activity from adrenal medulla. Is it involved in the processing of proenkephalin?". Life Sci. 31: 1793–1796. doi:10.1016/0024-3205(82)90212-0. PMID 6130442.

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案内

carboxypeptidase B