1-ピロリン-5-カルボン酸脱水素酵素、1-ピロリン-5-カルボン酸デヒドロゲナーゼ
- 関
- P5CDH
WordNet
- treat (a chemical compound) with carboxyl or carboxylic acid
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/05/22 19:51:18」(JST)
[Wiki en表示]
| 1-pyrroline-5-carboxylate dehydrogenase |
| Identifiers |
| EC number |
1.2.1.88 |
| CAS number |
9054-82-4 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a 1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) is an enzyme that catalyzes the chemical reaction
- (S)-1-pyrroline-5-carboxylate + NAD+ + 2 H2O L-glutamate + NADH + H+
The three substrates of this enzyme are (S)-1-pyrroline-5-carboxylate, NAD+, and H2O, whereas its three products are glutamate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-1-pyrroline-5-carboxylate:NAD+ oxidoreductase. Other names in common use include delta-1-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, and 1-pyrroline-5-carboxylate:NAD+ oxidoreductase. This enzyme participates in glutamate metabolism and arginine and proline metabolism.
Structural studies
As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 2BHP, 2BHQ, 2BJA, 2BJK, 2EHQ, 2EHU, 2EII, 2EIT, 2EIW, 2EJ6, 2EJD, 2EJL, 2IY6, and 2J40.
References
- Adams E; Goldstone A (1960). "Hydroxyproline metabolism. IV. Enzymatic synthesis of gamma-hydroxyglutamate from Delta1-pyrroline-3-hydroxy-5-carboxylate". J. Biol. Chem. 235: 3504–3512. PMID 13681370.
- Strecker HJ (1960). "The interconversion of glutamic acid proline. III Delta1-Pyrroline-5-carboxylic acid dehydrogenase". J. Biol. Chem. 235: 3218–3223.
|
Metabolism: Protein metabolism, synthesis and catabolism enzymes
|
|
|
Essential amino acids are in Capitals
|
|
| K→acetyl-CoA |
| LYSINE→ |
- Saccharopine dehydrogenase
- Glutaryl-CoA dehydrogenase
|
|
| LEUCINE→ |
- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- Isovaleryl coenzyme A dehydrogenase
- Methylcrotonyl-CoA carboxylase
- Methylglutaconyl-CoA hydratase
- 3-hydroxy-3-methylglutaryl-CoA lyase
|
|
| TRYPTOPHAN→ |
- Indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase
- Arylformamidase
- Kynureninase
- 3-hydroxyanthranilate oxidase
- Aminocarboxymuconate-semialdehyde decarboxylase
- Aminomuconate-semialdehyde dehydrogenase
|
|
| PHENYLALANINE→tyrosine→ |
|
|
|
| G |
G→pyruvate
→citrate |
| glycine→serine→ |
- Serine hydroxymethyltransferase
- Serine dehydratase
- glycine→creatine: Guanidinoacetate N-methyltransferase
- Creatine kinase
|
|
| alanine→ |
|
|
| cysteine→ |
|
|
| threonine→ |
- L-threonine dehydrogenase
|
|
|
G→glutamate→
α-ketoglutarate |
| HISTIDINE→ |
- Histidine ammonia-lyase
- Urocanate hydratase
- Formiminotransferase cyclodeaminase
|
|
| proline→ |
- Proline oxidase
- Pyrroline-5-carboxylate reductase
- 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1
- PYCR1
|
|
| arginine→ |
- Ornithine aminotransferase
- Ornithine decarboxylase
- Agmatinase
|
|
| →alpha-ketoglutarate→TCA |
|
|
| Other |
- cysteine+glutamate→glutathione: Gamma-glutamylcysteine synthetase
- Glutathione synthetase
- Gamma-glutamyl transpeptidase
- glutamate→glutamine: Glutamine synthetase
- Glutaminase
|
|
|
G→propionyl-CoA→
succinyl-CoA |
| VALINE→ |
- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- Enoyl-CoA hydratase
- 3-hydroxyisobutyryl-CoA hydrolase
- 3-hydroxyisobutyrate dehydrogenase
- Methylmalonate semialdehyde dehydrogenase
|
|
| ISOLEUCINE→ |
- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
|
|
| METHIONINE→ |
- generation of homocysteine: Methionine adenosyltransferase
- Adenosylhomocysteinase
- regeneration of methionine: Methionine synthase/Homocysteine methyltransferase
- Betaine-homocysteine methyltransferase
- conversion to cysteine: Cystathionine beta synthase
- Cystathionine gamma-lyase
|
|
| THREONINE→ |
|
|
| →succinyl-CoA→TCA |
- Propionyl-CoA carboxylase
- Methylmalonyl CoA epimerase
- Methylmalonyl-CoA mutase
|
|
|
| G→fumarate |
| PHENYLALANINE→tyrosine→ |
- Phenylalanine hydroxylase
- Tyrosine aminotransferase
- 4-Hydroxyphenylpyruvate dioxygenase
- Homogentisate 1,2-dioxygenase
- Fumarylacetoacetate hydrolase
- tyrosine→melanin: Tyrosinase
|
|
|
| G→oxaloacetate |
| asparagine→aspartate→ |
- Asparaginase/Asparagine synthetase
- Aspartate transaminase
|
|
|
|
Oxidoreductases: CH-NH (EC 1.5)
|
|
| 1.5.1: NAD or NADP acceptor |
- Dihydrofolate reductase
- Saccharopine dehydrogenase
- Methylenetetrahydrofolate reductase
|
|
| 1.5.3: oxygen acceptor |
- Dihydrobenzophenanthridine oxidase
- Sarcosine oxidase
- Proline oxidase
|
|
| 1.5.5: quinone acceptor |
- Electron-transferring-flavoprotein dehydrogenase
|
|
| 1.5.99 |
- Sarcosine dehydrogenase
- Cytokinin dehydrogenase
|
|
Enzymes
|
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
|
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
|
| Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
|
| Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death.
- Natarajan SK, Zhu W, Liang X, Zhang L, Demers AJ, Zimmerman MC, Simpson MA, Becker DF.SourceDepartment of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
- Free radical biology & medicine.Free Radic Biol Med.2012 Sep 1;53(5):1181-91. Epub 2012 Jul 13.
- Proline metabolism has an underlying role in apoptotic signaling that influences tumorigenesis. Proline is oxidized to glutamate in the mitochondria, with the rate-limiting step catalyzed by proline dehydrogenase (PRODH). PRODH expression is inducible by p53, leading to increased proline oxidation,
- PMID 22796327
- Protection from the acquisition of Staphylococcus aureus nasal carriage by cross-reactive antibody to a pneumococcal dehydrogenase.
- Lijek RS, Luque SL, Liu Q, Parker D, Bae T, Weiser JN.SourceDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2012 Aug 21;109(34):13823-8. Epub 2012 Aug 6.
- Nasal colonization by Staphylococcus aureus is the major risk factor for disease and transmission. Epidemiological studies have reported a reduced risk of S. aureus carriage in immunocompetent but not in immunocompromised children colonized by Streptococcus pneumoniae. We investigate the hypothesis
- PMID 22869727
Japanese Journal
- Effect of Proline and Arginine Metabolism on Freezing Stress of Saccharomyces cerevisiae(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Journal of bioscience and bioengineering 94(5), 390-394, 2002-11-25
- NAID 110002665031
- A nuclear gene encoding mitochondrial Δ^1-pyrroline-5-carboxylate dehydrogenase and its potential role in protection from proline toxicity
- Purification of Δ^1-pyrroline-5-carboxylate dehydrogenase from Spinacia oleracea L.
Related Links
- 1-pyr·ro·line-5-car·box·y·late de·hy·dro·gen·ase (pir'ō-lēn-kar-boks'i-lāt dē-hī'drō'gen-ās), An enzyme that catalyzes the reversible reaction of 1-pyrroline 5-carboxylate and NAD + to form l-glutamate and NADH; this enzyme plays a role ...
- EC number 1.5.1.12 Systematic name 1-pyrroline-5-carboxylate:NAD+ oxidoreductase Recommended name 1-pyrr ... Small, W.C.; Jones, M.E.: Pyrroline 5-carboxylate dehydrogenase of the mitochondrial matrix of rat liver.
- 1. Plant Cell. 2004 Dec;16(12):3413-25. Epub 2004 Nov 17. The role of [Delta]1-pyrroline-5-carboxylate dehydrogenase in proline degradation. Deuschle K, Funck D, Forlani G, Stransky H, Biehl A, Leister D, van der Graaff E, Kunze R ...
★リンクテーブル★
[★]
- 英
- 1-pyrroline-5-carboxylate dehydrogenase、P5CDH
- 関
- 1-ピロリン-5-カルボン酸脱水素酵素
[★]
- 英
- 1-pyrroline-5-carboxylate dehydrogenase
- 関
- 1-ピロリン-5-カルボン酸デヒドロゲナーゼ
[★]
- 関
- 1-pyrroline-5-carboxylate dehydrogenase
[★]
- 関
- carboxylic acid
[★]
- 関
- carboxylation
[★]
脱水素酵素 デヒドロゲナーゼ
[★]
脱水素酵素 デヒドロゲナーゼ