カルバミノヘモグロビン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/06/20 06:59:21」(JST)
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Carbaminohemoglobin (or Carbaminohaemoglobin, also known as carbhaemoglobin and carbohaemoglobin) is a compound of haemoglobin and carbon dioxide, and is one of the forms in which carbon dioxide exists in the blood. 10% of carbon dioxide is carried in blood this way (85% carried in blood as bicarbonate [hydrogen carbonate], 5% carried as free CO2, in solution).
Contents
- 1 Mechanism
- 2 See also
- 3 References
- 4 External links
Mechanism
When carbon dioxide binds to haemoglobin, carbaminohemoglobin is formed, lowering haemoglobin's affinity for oxygen via the Bohr effect. In the absence of oxygen, unbound haemoglobin molecules have a greater chance of becoming carbaminohaemoglobin. (The Haldane Effect relates to the increased affinity of de-oxygenated haemoglobin for H+: offloading of oxygen to the tissues thus results in increased affinity of the haemoglobin for carbon dioxide, and H+ - which the body wants to be rid of- which can then be transported to the lung for removal). Carbaminohemoglobin has a distinctive blue color that may contribute to the dark red color of deoxygenated venous blood (compared to bright, saturated red of oxygenated arterial blood), blue color of veins and the purplish or bluish color of tissues in hypoxia.
Hemoglobin can bind to four molecules of carbon dioxide. The carbon dioxide molecules form an amide linkage to the four terminal-amine groups of the four protein chains in the deoxy form of the molecule. Thus, one hemoglobin molecule can transport four carbon dioxide molecules back to the lungs, where they are released when the molecule changes back to the oxyhemoglobin form.
See also
- Haemoglobin
- Blood
- Carbamino
References
http://books.google.com/books?id=sKT2Sq4P0j8C&pg=PA431&lpg=PA431&dq=carbon+dioxide+does+not+bind+hemoglobin+at+the+same+site+as+oxygen&source=bl&ots=Y1Oi0bVbtB&sig=Jb6R_sJvGb5LtqB6jB0BXo_UmbA&hl=en&ei=08CNSqSkM6iRtgeI9rCCDg&sa=X&oi=book_result&ct=result&resnum=10#
External links
- carbaminohaemoglobin at eMedicine Dictionary
- carbaminohaemoglobin A at the US National Library of Medicine Medical Subject Headings (MeSH)
Proteins: hemeproteins
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Globins |
Hemoglobin |
Subunits |
Alpha locus on 16: |
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Beta locus on 11: |
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Tetramers |
stages of development: |
Embryonic
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- HbE Gower 1 (ζ2ε2)
- HbE Gower 2 (α2ε2)
- HbE Portland I (ζ2γ2)
- HbE Portland II (ζ2β2)
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Fetal
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- HbF/Fetal (α2γ2)
- HbA (α2β2)
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Adult
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- HbA (α2β2)
- HbA2 (α2δ2)
- HbF/Fetal (α2γ2)
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pathology: |
- HbH (β4)
- Barts (γ4)
- HbS (α2βS2)
- HbC (α2βC2)
- HbE (α2βE2)
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Compounds |
- Carboxyhemoglobin
- Carbaminohemoglobin
- Oxyhemoglobin/Deoxyhemoglobin
- Sulfhemoglobin
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Other human |
- Glycated hemoglobin
- Methemoglobin
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Nonhuman |
- Chlorocruorin
- Erythrocruorin
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Other |
human: |
- Myoglobin
- Neuroglobin
- Cytoglobin
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plant: |
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Other |
- Cytochrome
- Cytochrome b
- Cytochrome P450
- Hemocyanin
- Methemalbumin
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see also disorders of globin and globulin proteins
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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English Journal
- Simple accurate mathematical models of blood HbO2 and HbCO 2 dissociation curves at varied physiological conditions: evaluation and comparison with other models.
- Dash RK1, Korman B, Bassingthwaighte JB.
- European journal of applied physiology.Eur J Appl Physiol.2015 Aug 23. [Epub ahead of print]
- PURPOSE: Equations for blood oxyhemoglobin (HbO2) and carbaminohemoglobin (HbCO2) dissociation curves that incorporate nonlinear biochemical interactions of oxygen and carbon dioxide with hemoglobin (Hb), covering a wide range of physiological conditions, are crucial for a number of practical applic
- PMID 26298270
Related Links
- carbaminohemoglobin carb·a·mi·no·he·mo·glo·bin (kär'bə-mē'nō-hē'mə-glō'bĭn, kär-bām'ə-nō-) n. A compound of carbon dioxide and hemoglobin, which is one of the forms in which carbon dioxide exists in the blood.
- carbaminohemoglobin [kahr-bam″ĭ-no-he´mo-glo″bin] a combination of carbon dioxide and hemoglobin, CO 2 HHb, being one of the forms in which carbon dioxide exists in the blood. car·bam·i·no·he·mo·glo·bin (kar-bam'i-nō-hē'mō-glō ...
Related Pictures
★リンクテーブル★
[★]
- 英
- oxygen dissociation curve, ODC
- 同
- 酸素平衡曲線 oxygen equilibrium curve、酸素飽和曲線 oxygen saturation curve、酸素結合曲線 oxygen binding curve、ヘモグロビン酸素解離曲線 hemoglobin-oxygen dissociation curve
- 関
- 酸素飽和度、ヘモグロビン
解離曲線の右方シフト (SP.651)
- 酸素親和性が低く、酸素を解離しやすい。末梢で酸素供給量は増す
- 1. 温度上昇
- 結合-解離へ以降は解離側に傾く
- アルカリ性ボーア効果。CO2の共存下で作用減弱。CO2とH2が競合するので
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- 1-3は発熱部位、pH低下、PCO2が高いところでO2を放出するわけで、合理的
- ATP増加
解離曲線の左方シフト (SP.652)
生理的
- 酸素親和性が高く、酸素を結合しやすい。末梢で酸素供給量は減る
- 1. 温度低下
- 2. pH上昇
- 3. PCO2低下
- 5. 2,3-DPG減少
非生理的
[★]
- 英
- carbaminohemoglobin, carbamino-Hb
- 同
- カルバモイルヘモグロビン carbamoylhemoglobin, カルボヘモグロビン carbohemoglobin
- 関
- 血液による二酸化炭素輸送で、血中に溶解した二酸化炭素の一部がヘモグロビンのアミノ基と結合して形成する。
- 血液を介して運搬されるCO2の約20%がこの型である。
- Hb-NHCOOH