WordNet

of or relating to hair
a tube of small internal diameter; holds liquid by capillary action (同)capillary tube, capillary tubing
any of the minute blood vessels connecting arterioles with venules (同)capillary_vessel
long and slender with a very small internal diameter; "a capillary tube" (同)hairlike
the property of something that can be pervaded by a liquid (as by osmosis or diffusion) (同)permeableness

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毛状の,毛のように細い / 毛細管の / 毛細管
浸透性

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/29 07:37:13」(JST)

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Vascular permeability, often in the form of capillary permeability or microvascular permeability, characterizes the capacity of a blood vessel wall to allow for the flow of small molecules (ions, water, nutrients) or even whole cells (lymphocytes on their way to the site of inflammation) in and out of the vessel. Blood vessel walls are lined by a single layer of endothelial cells. The gaps between endothelial cells (cell junctions) are strictly regulated depending on the type and physiological state of the tissue.

There are several techniques to measure vascular permeability to certain molecules. For instance, the cannulation of a single microvessel with a micropipette, the microvessel is perfused with a certain pressure, occluded downstream and then the velocity of some cells will be related to the permeability.^[1]^[2] Another technique uses multiphoton fluorescence intravital microscopy through which the flow is related to fluorescence intensity and the permeability is estimated from the Patlak transformation ^[3] of the intensity data ^[4]

In cancer research, the study of permeability of the microvasculature that surrounds tumours is of great interest as the vascular wall is a barrier of large molecules into the tumours, the vessels control the microenvironment which affect tumour progression and changes to the permeability may indicate vascular damage with drugs,.^[4]^[5]

An example of increased vascular permeability is in the initial lesion of periodontal disease, in which the gingival plexus becomes engorged and dilated, allowing large numbers of neutrophils to extravasate and appear within the junctional epithelium and underlying connective tissue.^[6]

References[edit]

^ Michel, C. C., Mason, J. C., Curry, F. E. & Tooke, J. E. Development of Landis Technique for Measuring Filtration Coefficient of Individual Capillaries in Frog Mesentery. Q J Exp Physiol Cms 59, 283-309 (1974).
^ Bates, D. O. & Harper, S. J. Regulation of vascular permeability by vascular endothelial growth factors. Vascul Pharmacol 39, 225-237 (2002)
^ Patlak, C. S., Blasberg, R. G. & Fenstermacher, J. D. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3, 1-7 (1983).
^ ^a ^b Reyes-Aldasoro, C. C. et al. Estimation of apparent tumor vascular permeability from multiphoton fluorescence microscopic images of P22 rat sarcomas in vivo. Microcirculation 15, 65-79 (2008).
^ Tozer GM, Kanthou C, Baguley BC. (2005). Disrupting tumour blood vessels. Nat Rev Cancer 5:423– 435
^ Page, RC; Schroeder, HE. "Pathogenesis of Inflammatory Periodontal Disease: A Summary of Current Work." Lab Invest 1976;34(3):235-249

External links[edit]

Vascular Permeability at the US National Library of Medicine Medical Subject Headings (MeSH)

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1. 成人における浮腫の病態生理および病因 pathophysiology and etiology of edema in adults
2. 特発性全身性毛細血管漏出症候群 idiopathic systemic capillary leak syndrome
3. 非心原性肺水腫 noncardiogenic pulmonary edema
4. 小児における浮腫の病態生理および病因 pathophysiology and etiology of edema in children
5. 神経原性肺水腫 neurogenic pulmonary edema

English Journal

Effect of Melilotus extract on lung injury via the upregulation of tumor necrosis factor-α-induced protein-8-like 2 in septic mice.

Liu MW1, Su MX2, Wang YH1, Qian CY1.
Molecular medicine reports.Mol Med Rep.2015 Mar;11(3):1675-84. doi: 10.3892/mmr.2014.2965. Epub 2014 Nov 17.
As a Traditional Chinese Medicine, Melilotus extracts have been reported to function as an anti‑inflammatory agent, antioxidant and inhibitor of capillary permeability. The present study aimed to identify the mechanisms by which Melilotus interferes with inflammation‑associated and oxidative str
PMID 25405912

The role of the microvascular tortuosity in tumor transport phenomena.

Penta R1, Ambrosi D2.
Journal of theoretical biology.J Theor Biol.2015 Jan 7;364:80-97. doi: 10.1016/j.jtbi.2014.08.007. Epub 2014 Sep 8.
The role of the microvascular network geometry in transport phenomena in solid tumors and its interplay with the leakage and pressure drop across the vessels is qualitatively and quantitatively discussed. Our starting point is a multiscale homogenization, suggested by the sharp length scale separati
PMID 25218498

The Hydrocortisone Protection of Glycocalyx on the Intestinal Capillary Endothelium During Severe Acute Pancreatitis.

Gao S1, Zhang Y, Zhang S, Liang Z, Yu W, Liang T.
Shock (Augusta, Ga.).Shock.2015 Jan 6. [Epub ahead of print]
INTRODUCTION: Malfunctioning of the intestinal microcirculation secondary to severe acute pancreatitis (SAP) can cause injuries to the intestinal mucosal barrier, translocation of gut flora, and sepsis. The glycocalyx on the vascular endothelium helps to maintain its normal function through multiple
PMID 25565639