WordNet
- the dome of the skull (同)skullcap
- of or relating to or associated with the parietal bones in the cranium; "parietal lobe"
- the bony skeleton of the head of vertebrates
- the part of the skull that encloses the brain (同)braincase, brainpan
PrepTutorEJDIC
- 頭頂[骨]の / 大学構内居住に関する
- 『頭がい骨』,しゃれこうべ / 《話》おつむ,頭
- 頭蓋
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/18 18:24:59」(JST)
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- 1. 無脳症 anencephaly
- 2. 小児における急性乳様突起炎：臨床的特徴および診断 acute mastoiditis in children clinical features and diagnosis
- 3. 頭蓋骨縫合早期癒合症候群 craniosynostosis syndromes
- 4. 成人における顔面外傷 facial trauma in adults
- 5. 妊娠中期の中絶：概要および外科的中絶 second trimester pregnancy termination overview and surgical termination
English Journal
- Connective Tissue Growth Factor (CTGF/CCN2) Negatively Regulates BMP-2 Induced Osteoblast Differentiation and Signaling.
- Mundy C, Gannon M, Popoff SN.Author information Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, Pennsylvania.AbstractConnective tissue growth factor (CTGF/CCN2) and bone morphogenetic protein (BMP)-2 are both produced and secreted by osteoblasts. Both proteins have been shown to have independent effects in regulating osteoblast proliferation, maturation and mineralization. However, how these two proteins interact during osteoblast differentiation remains unknown. In this study, we utilized two cell culture model systems, osteoblasts derived from CTGF knockout (KO) mice and osteoblasts infected with an adenovirus which over-expresses CTGF (Ad-CTGF), to investigate the effects of CTGF and BMP-2 on osteoblast development and function in vitro. Contrary to a previously published report, osteoblast maturation and mineralization were similar in osteogenic cultures derived from KO and WT calvaria in the absence of BMP-2 stimulation. Interestingly, in KO and WT osteoblast cultures stimulated with BMP-2, the KO osteoblasts exhibited enhanced osteoblast differentiation. This increase in osteoblast differentiation was accompanied by increased protein levels of phosphorylated Smad 1/5/8 and mRNA expression levels of bone morphogenetic protein receptor Ib. We also examined osteoblast differentiation in cultures that were infected with an adenoviral-CTGF vector (Ad-CTGF) and in controls. Continuous over-expression of CTGF resulted in decreased osteoblast maturation and mineralization in both unstimulated and BMP-2 stimulated cultures. Impaired osteoblast differentiation in cultures over-expressing CTGF was accompanied by decreased protein levels of phosphorylated Smad 1/5/8. Collectively, the data from these studies demonstrate that CTGF acts to negatively regulate BMP-2 induced signaling and osteoblast differentiation, and warrant additional studies to determine the precise mechanism(s) responsible for this effect. J. Cell. Physiol. 229: 672-681, 2014. © 2013 Wiley Periodicals, Inc.
- Journal of cellular physiology.J Cell Physiol.2014 May;229(5):672-81. doi: 10.1002/jcp.24491.
- Connective tissue growth factor (CTGF/CCN2) and bone morphogenetic protein (BMP)-2 are both produced and secreted by osteoblasts. Both proteins have been shown to have independent effects in regulating osteoblast proliferation, maturation and mineralization. However, how these two proteins interact
- PMID 24127409
- Magnetic resonance imaging for monitoring therapeutic response in a transgenic mouse model of Alzheimer's disease using voxel-based analysis of amyloid plaques.
- Kim JH, Ha TL, Im GH, Yang J, Seo SW, Chung JJ, Chae SY, Lee IS, Lee JH.Author information Departments of aRadiology bNeurology, Samsung Medical Center, Sungkyunkwan University School of Medicine cCenter for Molecular and Cellular Imaging, Samsung Biomedical Research Institute dSamsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul eDepartment of Applied Chemistry, Kyung Hee University, Gyeonggi-do fDepartment of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Korea.AbstractIn this study, we have shown the potential of a voxel-based analysis for imaging amyloid plaques and its utility in monitoring therapeutic response in Alzheimer's disease (AD) mice using manganese oxide nanoparticles conjugated with an antibody of Aβ1-40 peptide (HMON-abAβ40). T1-weighted MR brain images of a drug-treated AD group (n=7), a nontreated AD group (n=7), and a wild-type group (n=7) were acquired using a 7.0 T MRI system before (D-1), 24-h (D+1) after, and 72-h (D+3) after injection with an HMON-abAβ40 contrast agent. For the treatment of AD mice, DAPT was injected intramuscularly into AD transgenic mice (50 mg/kg of body weight). For voxel-based analysis, the skull-stripped mouse brain images were spatially normalized, and these voxels' intensities were corrected to reduce voxel intensity differences across scans in different mice. Statistical analysis showed higher normalized MR signal intensity in the frontal cortex and hippocampus of AD mice over wild-type mice on D+1 and D+3 (P<0.01, uncorrected for multiple comparisons). After the treatment of AD mice, the normalized MR signal intensity in the frontal cortex and hippocampus decreased significantly in comparison with nontreated AD mice on D+1 and D+3 (P<0.01, uncorrected for multiple comparisons). These results were confirmed by histological analysis using a thioflavin staining. This unique strategy allows us to detect brain regions that are subjected to amyloid plaque deposition and has the potential for human applications in monitoring therapeutic response for drug development in AD.
- Neuroreport.Neuroreport.2014 Mar 5;25(4):211-8. doi: 10.1097/WNR.0000000000000067.
- In this study, we have shown the potential of a voxel-based analysis for imaging amyloid plaques and its utility in monitoring therapeutic response in Alzheimer's disease (AD) mice using manganese oxide nanoparticles conjugated with an antibody of Aβ1-40 peptide (HMON-abAβ40). T1-weighted MR brain
- PMID 24518227
- Transcranial segment of the trigeminal nerve: macro-/microscopic anatomical study using sheet plastination.
- Liang L, Diao Y, Xu Q, Zhang M.Author information Department of Anatomy, Capital Medical University, Beijing, China.AbstractBACKGROUND: Trigeminal neuralgia (TN) may be caused by the mechanical compression of the trigeminal nerve. In the studies on the location of mechanical irritation and entrapment of the nerve, attention has been paid mostly to vascular structures in the subarachnoid space. Few studies have explored the relationship between the trigeminal nerve and its surrounding structures along its course in the skull base. The aim of this study was to examine and trace the root, ganglion and three divisions of the trigeminal nerve and their relationships with surrounding soft and bony structures in the skull base, and to identify the likely mechanical compression points.
- Acta neurochirurgica.Acta Neurochir (Wien).2014 Mar;156(3):605-12. doi: 10.1007/s00701-013-1920-9. Epub 2013 Oct 26.
- BACKGROUND: Trigeminal neuralgia (TN) may be caused by the mechanical compression of the trigeminal nerve. In the studies on the location of mechanical irritation and entrapment of the nerve, attention has been paid mostly to vascular structures in the subarachnoid space. Few studies have explored t
- PMID 24158246
Japanese Journal
- ラット頭頂骨骨膜下におけるrhBMP-2添加多孔性キトサン/HAp複合体の骨伝導
- 原田 尚樹,柏崎 晴彦,赤澤 敏之,村田 勝,相沢 智康,出村 誠,田中 順三,飯塚 正,井上 農夫男
- キチン・キトサン研究 = Chitin and chitosan research 18(2), 112-113, 2012-07-01
- NAID 10030780489
- Osteogenic effect of fluvastatin combined with biodegradable gelatin-hydrogel
- TANABE Koji,NOMOTO Hideki,OKUMORI Naoto,MIURA Tadashi,YOSHINARI Masao
- Dental materials journal 31(3), 489-493, 2012-05-01
- … Two circular defects were surgically created on fifteen-week-old male rats calvaria. …
- NAID 10030315580
- P-13 リン酸オクタカルシウムの骨伝導能に及ぼす非晶質リン酸カルシウムの添加効果(生体反応,一般講演(ポスター発表),第59回日本歯科理工学会学術講演会)
- 小林 司史,穴田 貴久,本田 義知,半田 拓人,鎌倉 慎治,越後 成志,鈴木 治
- 日本歯科理工学会誌 31(2), 94, 2012-03-25
- … The present study was designed to investigate whether addition of amorphous calcium phosphate (ACP) into OCP in granule forms has an effect on raising the intrinsic osteoconductivity of OCP if implanted into critical sized rat calvaria defect. …
- NAID 110009358489
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★リンクテーブル★
| リンク元 | 「頭蓋冠」「頭頂部」「calvarium」「os parietale」 |
| 拡張検索 | 「calvarial」「calvariae」 |
「頭蓋冠」
- 神経頭蓋において、頭蓋底を覆う屋根状の構造
「頭頂部」
「calvarium」
「os parietale」
「calvarial」
- 頭蓋冠の、頭頂骨の、頭頂部の