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Micrograph of a malignant epithelioid mesothelioma stained with an antibody against calretinin.

Calretinin also known as 29 kDa calbindin is a vitamin D-dependent calcium-binding protein involved in calcium signaling. In humans, the calretinin protein is encoded by the CALB2 gene.^[1]^[2]

Function

This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability^[1]

Calretinin is abundantly expressed in neurons and in hair follicles.^[3]

Clinical significance

Calretinin is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers.

Mesothelioma

Using immunohistochemistry, calretinin can be demonstrated in both benign mesothelium and in malignant mesothelioma^[4] and can be used to help differentiate different lung tumours.^[5] Antibodies to calretinin can also be used to distinguish between different types of brain tumour, demonstrating only those with neuronal rather than glial, differentiation.^[6]

Hirschsprung disease

In Hirschsprung disease, calretinin IHC offers additional diagnostic value in specimens with inadequate amount of submucosa and rarely seen ganglion cells. The presence of ganglion cells consistently correlated with calretinin-positive thin nerve fibrils in the lamina propria, muscularis mucosae and superficial submucosa. These calretinin-positive thin nerve fibrils are absent in the aganglionic segments of bowel and in the areas without ganglion cells from the junction of normal with diseased rectum. Calretinin is strongly expressed in the submucosal and subserosal nerve trunks in the ganglionic segment. No calretinin expression is seen in the nerve trunks in the rest of the aganglionic segment. It has faint expression in the thick nerve trunks from the areas without ganglion cells. Faint positivity of the thick submucosal and subserosal nerves in the absence of ganglion cells and calretinin positive nerve fibrils, is characteristic of the junction of the aganglionic-to-normal rectum. ^[7]

References

^ ^a ^b "Entrez Gene: calbindin 2".
^ Parmentier M, Passage E, Vassart G, Mattei MG (1991). "The human calbindin D28k (CALB1) and calretinin (CALB2) genes are located at 8q21.3----q22.1 and 16q22----q23, respectively, suggesting a common duplication with the carbonic anhydrase isozyme loci". Cytogenet. Cell Genet. 57 (1): 41–3. doi:10.1159/000133111. PMID 1906795.
^ Poblet E, Jimenez F, de Cabo C, Prieto-Martin A, Sánchez-Prieto R (June 2005). "The calcium-binding protein calretinin is a marker of the companion cell layer of the human hair follicle". Br. J. Dermatol. 152 (6): 1316–20. doi:10.1111/j.1365-2133.2005.06603.x. PMID 15948999.
^ Saydan N, Salicio V, Cappelli-Gotzos B, Gotzos V (2001). "Expression of calretinin in human mesothelioma cell lines and cell cycle analysis by flow cytometry". Anticancer Res. 21 (1A): 181–8. PMID 11299732.
^ Marchevsky AM (March 2008). "Application of immunohistochemistry to the diagnosis of malignant mesothelioma". Arch. Pathol. Lab. Med. 132 (3): 397–401. doi:10.1043/1543-2165(2008)132[397:AOITTD]2.0.CO;2. PMID 18318582.
^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. pp. 45–46. ISBN 1-84110-100-1.
^ Alexandrescu, S; Rosenberg, H; Tatevian, N (2013). "Role of calretinin immunohistochemical stain in evaluation of Hirschsprung disease: An institutional experience". International journal of clinical and experimental pathology 6 (12): 2955–61. PMC 3843278. PMID 24294384. edit

External links

calretinin at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

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English Journal

Functional regulation of neuronal nitric oxide synthase expression and activity in the rat retina.

Walter LT1, Higa GS2, Schmeltzer C3, Sousa E1, Kinjo ER1, Rüdiger S3, Hamassaki DE4, Cerchiaro G5, Kihara AH6.
Experimental neurology.Exp Neurol.2014 Nov;261:510-7. doi: 10.1016/j.expneurol.2014.07.019. Epub 2014 Aug 6.
In the nervous system within physiological conditions, nitric oxide (NO) production depends on the activity of nitric oxide synthases (NOSs), and particularly on the expression of the neuronal isoform (nNOS). In the sensory systems, the role of NO is poorly understood. In this study, we identified n
PMID 25116452

GABAB receptors in maintenance of neocortical circuit function.

Sebe JY1, Looke-Stewart E1, Baraban SC2.
Experimental neurology.Exp Neurol.2014 Nov;261:163-70. doi: 10.1016/j.expneurol.2014.05.018. Epub 2014 May 26.
Activation of metabotropic GABAB receptors (GABABRs) enhances tonic GABA current and substantially increases the frequency of spontaneous seizures. Despite the and pro-epileptic consequences of GABABR activation, mice lacking functional GABAB receptors (GABAB1R KO mice) exhibit clonic and rare absen
PMID 24873729

Müllerian Adenosarcoma of the Uterus With Low-grade Sarcomatous Overgrowth Characterized by Prominent Hydropic Change Resulting in Mimicry of a Smooth Muscle Tumor.

Wu RI1, Schorge JO, Cin PD, Young RH, Oliva E.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.Int J Gynecol Pathol.2014 Nov;33(6):573-80. doi: 10.1097/PGP.0000000000000100.
A 28-y-old woman was found to have a large subserosal uterine mass that was excised and interpreted as a "clear cell leiomyoma." Five years later, the tumor recurred as serosal-based ileal and uterine masses; they were treated by partial ileal resection and hysterectomy. All 3 masses were predominan
PMID 25272296

Japanese Journal

P-013 カエル舌の茸状乳頭におけるサブスタンスP、カルシトニン遺伝子関連ペプチドおよびカルレチニンの免疫組織化学的局在(ポスターセッション,2012年度日本味と匂学会第46回大会)

安藤宏,田所治,川原一郎,奥村雅代,金銅英二,中村貴美,富田美穂子,浅沼直和
日本味と匂学会誌 19(3), 303-306, 2012-12-00
NAID 110009578259

〈原著〉子宮内膜症の発生に関する病理組織学的・免疫組織化学的検討

生駒直子,小畑孝四郎,天野陽子,大村元,三橋洋治,井上芳樹,太田善夫
近畿大学医学雑誌 37(3-4), 173-179, 2012-09-00
… 例，卵巣チョコレート囊胞10例の手術摘出標本を用いて，病理組織学的にそれらの形態を詳細に検討するとともに，エストロゲンレセプター（ER），プロゲステロンレセプター（PR），中皮のマーカーであるcalretinin，中皮と扁平上皮以外の上皮に発現がみられるBer-EP4，ならびにHER2蛋白を免疫組織化学的に染色し，それらの発現状態を検討し，その発生過程ならびに発癌に関する生物学的特性の差異を調べた．その結果 …
NAID 120004969543

横隔膜部胸膜より発生した石灰化線維性偽腫瘍の一例

藤田琢也,井上修平,尾崎良智,大内政嗣,手塚則明,花岡淳
日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery 26(4), 453-458, 2012-05-15
症例は58歳の女性．健康診断の胸部X線で異常を指摘され来院した．胸部CTでは右の肋骨横隔膜角部に 4×2cm大の漸増性に造影される腫瘤影を認め，胸部MRI所見ではT2強調画像で著明な低信号を示し孤立性線維性腫瘍等を疑い，胸腔鏡下手術を施行した．手術所見で横隔膜部胸膜より発生した有茎性腫瘍を認めた．腫瘍は，病理検査所見では細胞成分の少ない線維性組織が主体で異型細胞は認めず砂粒状石灰化が認められ，免疫 …
NAID 10030435795

Related Pictures

★リンクテーブル★

リンク元

「カルレチニン」

Calbindin 2
Identifiers
Symbols	CALB2 ; CAB29; CAL2; CR
External IDs	OMIM: 114051 MGI: 101914 HomoloGene: 1318 GeneCards: CALB2 Gene
Gene ontology
Molecular function	• calcium ion binding;
Cellular component	• cytoplasm; • gap junction;
	Sources: Amigo / QuickGO
Orthologs
	v; t; e;

　　[★]

英: calretinin
関: 胸膜中皮腫

カルレチニン染色により中皮細胞を特異的に染色することができる。

[entrez-1] "Entrez Gene: calbindin 2".

[pmid1906795-2] Parmentier M, Passage E, Vassart G, Mattei MG (1991). "The human calbindin D28k (CALB1) and calretinin (CALB2) genes are located at 8q21.3----q22.1 and 16q22----q23, respectively, suggesting a common duplication with the carbonic anhydrase isozyme loci". Cytogenet. Cell Genet. 57 (1): 41–3. doi:10.1159/000133111. PMID 1906795.

[pmid15948999-3] Poblet E, Jimenez F, de Cabo C, Prieto-Martin A, Sánchez-Prieto R (June 2005). "The calcium-binding protein calretinin is a marker of the companion cell layer of the human hair follicle". Br. J. Dermatol. 152 (6): 1316–20. doi:10.1111/j.1365-2133.2005.06603.x. PMID 15948999.

[pmid11299732-4] Saydan N, Salicio V, Cappelli-Gotzos B, Gotzos V (2001). "Expression of calretinin in human mesothelioma cell lines and cell cycle analysis by flow cytometry". Anticancer Res. 21 (1A): 181–8. PMID 11299732.

[pmid18318582-5] Marchevsky AM (March 2008). "Application of immunohistochemistry to the diagnosis of malignant mesothelioma". Arch. Pathol. Lab. Med. 132 (3): 397–401. doi:10.1043/1543-2165(2008)132[397:AOITTD]2.0.CO;2. PMID 18318582.

[Leong-6] Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. pp. 45–46. ISBN 1-84110-100-1.

[7] Alexandrescu, S; Rosenberg, H; Tatevian, N (2013). "Role of calretinin immunohistochemical stain in evaluation of Hirschsprung disease: An institutional experience". International journal of clinical and experimental pathology 6 (12): 2955–61. PMC 3843278. PMID 24294384. edit

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calretinin