関: calcium oscillation、calcium signaling、calcium wave

WordNet

stand in the way of
add alcohol to (beverages); "the punch is spiked!" (同)lace, fortify
bring forth a spike or spikes; "my hyacinths and orchids are spiking now" (同)spike out
(botany) an indeterminate inflorescence bearing sessile flowers on an unbranched axis
manifest a sharp increase; "the voltage spiked"
any holding device consisting of a rigid, sharp-pointed object; "the spike pierced the receipts and held them in order" (同)spindle
a large stout nail; "they used spikes to fasten the rails to a railroad tie"
a long, thin sharp-pointed implement (wood or metal); "one of the spikes impaled him"
a sharp-pointed projection along the top of a fence or wall (or a dinosaur)
each of the sharp points on the soles of athletic shoes to prevent slipping (or the shoes themselves); "the second baseman sharpened his spikes before every game"; "golfers spikes damage the putting greens"
sports equipment consisting of a sharp point on the sole of a shoe worn by athletes; "spikes provide greater traction"
a sharp rise followed by a sharp decline; "the seismograph showed a sharp spike in response to the temblor"
a transient variation in voltage or current
secure with spikes
a white metallic element that burns with a brilliant light; the fifth most abundant element in the earths crust; an important component of most plants and animals (同)Ca, atomic number 20
having a long sharp point

PrepTutorEJDIC

大くぎ;(鉄道用)いぬくぎ / (へいの忍び返しなどの)先のとがった突起 / スパイク(野救・陸上競技用の靴底の金具) / (…に)…‘を'大くぎで打ちつける《+『名』+『to』+『名』》 / …‘に'大くぎ(スパイク)を打ちつける / 〈人〉‘を'すぱいくしゅ‐ずで傷つける;すぱいくする
(麦などの)穂 / (オオバコなどの)穂(すい)状花序
『カルシウム』(金属元素;化学記号は『Ca』)

UpToDate Contents

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1. 思春期におけるカルシウムの所要量 calcium requirements in adolescents
2. 骨粗鬆症におけるカルシウムおよびビタミンDの補充 calcium and vitamin d supplementation in osteoporosis
3. カルシウムおよびリン酸バランスの調節 regulation of calcium and phosphate balance
4. 成人におけるカルシウム結石の危険因子 risk factors for calcium stones in adults
5. 成人における再発性カルシウム結石の予防 prevention of recurrent calcium stones in adults

English Journal

Monitoring intracellular calcium in response to GPCR activation using thin-film silicon photodiodes with integrated fluorescence filters.

Martins SA, Moulas G, Trabuco JR, Monteiro GA, Chu V, Conde JP, Prazeres DM.Author information INESC Microsistemas e Nanotecnologias (INESC MN), Rua Alves Redol 9, 1000-029 Lisbon, Portugal; IN-Institute of Nanoscience and Nanotechnology, Rua Alves Redol 9, 1000-029 Lisbon, Portugal; IBB-Institute for Biotechnology and Bioengineering, Instituto Superior Técnico, Avenida Rovisco Pais, 1049-001 Lisbon, Portugal.AbstractG-protein coupled receptor (GPCRs) drug discovery is a thriving strategy in the pharmaceutical industry. The standard approach uses living cells to test millions of compounds in a high-throughput format. Typically, changes in the intracellular levels of key elements in the signaling cascade are monitored using fluorescence or luminescence read-out systems, which require external equipment for signal acquisition. In this work, thin-film amorphous silicon photodiodes with an integrated fluorescence filter were developed to capture the intracellular calcium dynamics in response to the activation of the endogenous muscarinic M1 GPCR of HEK 293T cells. Using the new device it was possible to characterize the potency of carbachol (EC50=10.5 µM) and pirenzepine (IC50=4.2 μM), with the same accuracy as standard microscopy optical systems. The smaller foot-print provided by the detection system makes it an ideal candidate for the future integration in microfluidic devices for drug discovery.
Biosensors & bioelectronics.Biosens Bioelectron.2014 Feb 15;52:232-8. doi: 10.1016/j.bios.2013.08.037. Epub 2013 Sep 5.
G-protein coupled receptor (GPCRs) drug discovery is a thriving strategy in the pharmaceutical industry. The standard approach uses living cells to test millions of compounds in a high-throughput format. Typically, changes in the intracellular levels of key elements in the signaling cascade are moni
PMID 24055937

Chondroitin sulphate-based 3D scaffolds containing MWCNTs for nervous tissue repair.

Serrano MC1, Nardecchia S2, García-Rama C3, Ferrer ML2, Collazos-Castro JE3, Del Monte F2, Gutiérrez MC4.Author information 1Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain. Electronic address: conchi.serrano@icmm.csic.es.2Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain.3Neural Repair Laboratory, Hospital Nacional de Parapléjicos (SESCAM), Finca La Peraleda s/n, 45071 Toledo, Spain.4Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain. Electronic address: mcgutierrez@icmm.csic.es.AbstractNervous tissue lesions are an important social concern due to their increasing prevalence and their high sanitary costs. Their treatment still remains a challenge because of the reduced ability of nervous tissue to regenerate, its intrinsic structural and functional complexity and the rapid formation of fibroglial scars inhibiting neural repair. Herein, we show that 3D porous scaffolds made of chondroitin sulphate (CS), a major regulatory component of the nervous tissue, and multi-walled carbon nanotubes (MWCNTs) are selective substrates for the formation of a viable and neuron-enriched network with a transitory low glial content. Scaffolds have been fabricated by using the ice segregation-induced self-assembly technique and cultured with embryonic neural progenitor cells. Cell adhesion, morphology, viability, neuron/glial differentiation, calcium signaling dynamics, and mitochondrial activity have been studied over time on the scaffolds and compared to appropriate 2D control substrates. Our results indicate the formation of viable cultures enriched in neuron cells for up to 20 days, with ability to display calcium transients and active mitochondria, even in the absence of poly-d-lysine coating. A synergistic neural-permissive signaling from both the scaffold structure and its components (i.e., MWCNTs and CS) is suggested as the major responsible factor for these findings. We anticipate that these scaffolds may serve nerve regeneration if implanted in the acute phase after injury, as it is during the first stages of graft implantation when the most critical sequence of phenomena takes place to drive either nervous regeneration or fibroglial scar formation. The temporary glial inhibition found may be, indeed, beneficial for promoting the formation of neuron-enriched circuits at early phases while guaranteeing posterior glial integration to support longer-term neuron survival and activity.
Biomaterials.Biomaterials.2014 Feb;35(5):1543-51. doi: 10.1016/j.biomaterials.2013.11.017. Epub 2013 Nov 27.
Nervous tissue lesions are an important social concern due to their increasing prevalence and their high sanitary costs. Their treatment still remains a challenge because of the reduced ability of nervous tissue to regenerate, its intrinsic structural and functional complexity and the rapid formatio
PMID 24290440

Bioactivity of xerogels as modulators of osteoclastogenesis mediated by connexin 43.

Glenske K1, Wagner AS2, Hanke T3, Cavalcanti-Adam EA4, Heinemann S5, Heinemann C6, Kruppke B7, Arnhold S8, Moritz A9, Schwab EH10, Worch H11, Wenisch S12.Author information 1Clinic of Small Animals, c/o Institute of Veterinary-Anatomy, -Histology and -Embryology, Justus-Liebig-University Giessen, Frankfurter Str. 98, 35392 Giessen, Germany. Electronic address: Kristina.Glenske@vetmed.uni-giessen.de.2Clinic of Small Animals, c/o Institute of Veterinary-Anatomy, -Histology and -Embryology, Justus-Liebig-University Giessen, Frankfurter Str. 98, 35392 Giessen, Germany. Electronic address: Alena-Svenja.Wagner@vetmed.uni-giessen.de.3Max Bergmann Center of Biomaterials and Institute of Materials Science, Technische Universität Dresden, Budapester Str. 27, 01069 Dresden, Germany. Electronic address: Thomas.Hanke@tu-dresden.de.4Department of Physical Chemistry, Institute for Biophysical Chemistry, University of Heidelberg, INF 253, 69120 Heidelberg, Germany; Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, 70569 Stuttgart, Germany. Electronic address: Ada.Cavalcanti-Adam@urz.uni-heidelberg.de.5Max Bergmann Center of Biomaterials and Institute of Materials Science, Technische Universität Dresden, Budapester Str. 27, 01069 Dresden, Germany. Electronic address: Sascha.Heinemann@tu-dresden.de.6Max Bergmann Center of Biomaterials and Institute of Materials Science, Technische Universität Dresden, Budapester Str. 27, 01069 Dresden, Germany. Electronic address: Christine.Heinemann@tu-dresden.de.7Max Bergmann Center of Biomaterials and Institute of Materials Science, Technische Universität Dresden, Budapester Str. 27, 01069 Dresden, Germany. Electronic address: Benjamin.Kruppke@tu-dresden.de.8Institute of Veterinary-Anatomy, -Histology and -Embryology, Justus-Liebig-University Giessen, Frankfurter Str. 98, 35392 Giessen, Germany. Electronic address: Stefan.Arnhold@vetmed.uni-giessen.de.9Department of Veterinary Clinical Sciences, Clinical Pathology and Clinical Pathophysiology, Justus-Liebig-University Giessen, Giessen, Germany. Electronic address: Andreas.Moritz@vetmed.uni-giessen.de.10Department of Physical Chemistry, Institute for Biophysical Chemistry, University of Heidelberg, INF 253, 69120 Heidelberg, Germany; Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, 70569 Stuttgart, Germany. Electronic address: schwab@is.mpg.de.11Max Bergmann Center of Biomaterials and Institute of Materials Science, Technische Universität Dresden, Budapester Str. 27, 01069 Dresden, Germany. Electronic address: Hartmut.Worch@tu-dresden.de.12Clinic of Small Animals, c/o Institute of Veterinary-Anatomy, -Histology and -Embryology, Justus-Liebig-University Giessen, Frankfurter Str. 98, 35392 Giessen, Germany. Electronic address: Sabine.Wenisch@vetmed.uni-giessen.de.AbstractIn order to investigate the effects of different degrees of bioactivity of xerogels on connexin 43 (cx43) signaling of osteoclasts a cell culture approach was developed. Cells isolated from peripheral blood mononuclear cells were cultured in combination with the xerogels and were harvested for further investigations on day 1, day 5, and day 10. By means of quantitative PCR increased cx43 mRNA levels and coincident decreasing mRNA levels of the calcium sensing receptor, TRAP, and Cathepsin K were detected with increasing bioactivity of the xerogel samples. Additionally, osteoclasts cultured on tissue culture plates were used to perform principle investigations on cell differentiation by means of transmission electron microscopy, life cell imaging, and immunofluorescence, and the results demonstrated that cx43-signaling could be attributed to migration and fusion of osteoclast precursors. Therefore, the positive correlation of cx43 expression with high xerogel bioactivity was caused by proceeding differentiation of the osteoclasts. Finally, the presently observed pattern of cx43 signaling refers to strong effects regarding bioactivity on cx43-associated cell differentiation of osteoclasts influenced by extracellular calcium ions.
Biomaterials.Biomaterials.2014 Feb;35(5):1487-95. doi: 10.1016/j.biomaterials.2013.11.002. Epub 2013 Nov 20.
In order to investigate the effects of different degrees of bioactivity of xerogels on connexin 43 (cx43) signaling of osteoclasts a cell culture approach was developed. Cells isolated from peripheral blood mononuclear cells were cultured in combination with the xerogels and were harvested for furth
PMID 24268200

Japanese Journal

非同期順序回路を用いたシナプスモデルとそのスパイクタイミング依存シナプス可塑性

浦本拓実,鳥飼弘幸
電子情報通信学会技術研究報告. NLP, 非線形問題 111(395), 57-62, 2012-01-16
順序回路を用いてスパイクタイミング依存シナプス可塑性(STDP)を実現するシナプスモデルを提案する。従来の2本のスパイクに対するSTDPのみではなく、3本のスパイクに対するSTDPを再現するために、生物物理モデルに着想を得てシナプス内部のカルシウムのダイナミクスをモデルに取り入れることにより複数のスパイク入力に対しても実験データを再現できることを目指した。提案したモデルは海馬・視覚野第2/3層のシ …
NAID 110009481357

マンゴー果実の表面がくぼむ障害に対するカルシウム,ホウ素散布の効果

上之薗茂,西田学,橋元祥一
鹿児島県農業開発総合センター研究報告耕種部門 (5), 17-22, 2011-03
NAID 40018812244

「calcium oscillation」

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カルシウム振動、カルシウムオシレーション

関: calcium signaling、calcium spike、calcium wave

「calcium wave」

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カルシウムウェーブ、カルシウム波

関: calcium oscillation、calcium signaling、calcium spike

「calcium signaling」

　　[★]

カルシウムシグナリング

関: calcium oscillation、calcium spike、calcium wave

「カルシウムスパイク」

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英: calcium spike
同: Caスパイク
関: カルシウム、カルシウム電流

「spike」

　　[★]

n.

大釘、忍び返し。靴底の釘、スパイク
鋭くとがったもの
(理)スパイク。(生理)スパイク波
(物価などの)急騰

In addition, atherosclerosis of large arteries hinders their elasticity, resulting in systolic pressure spikes that can further traumatize endothelium or provoke events such as aneurysm rupture.(PHD.324)