カルシトニン受容体、カルシトニンレセプター CTR
WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- thyroid hormone that tends to lower the level of calcium in the blood plasma and inhibit resorption of bone (同)thyrocalcitonin
PrepTutorEJDIC
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/06 16:34:32」(JST)
[Wiki en表示]
| Calcitonin receptor |
| Identifiers |
| Symbols |
CALCR; CRT; CT-R; CTR; CTR1 |
| External IDs |
OMIM: 114131 MGI: 101950 HomoloGene: 1320 IUPHAR: CT receptor ChEMBL: 1832 GeneCards: CALCR Gene |
| Gene Ontology |
| Molecular function |
• receptor activity
• calcitonin receptor activity
• protein binding
• protein transporter activity
• calcitonin binding
|
| Cellular component |
• plasma membrane
• integral to plasma membrane
|
| Biological process |
• adenylate cyclase-activating G-protein coupled receptor signaling pathway
• activation of phospholipase C activity
• elevation of cytosolic calcium ion concentration
• protein transport
• positive regulation of cAMP biosynthetic process
• receptor internalization
• positive regulation of adenylate cyclase activity
• response to glucocorticoid stimulus
• protein localization to plasma membrane
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| Sources: Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
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| Entrez |
799 |
12311 |
|
| Ensembl |
ENSG00000004948 |
ENSMUSG00000023964 |
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| UniProt |
P30988 |
Q60755 |
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| RefSeq (mRNA) |
NM_001164737 |
NM_001042725 |
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| RefSeq (protein) |
NP_001158209 |
NP_001036190 |
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| Location (UCSC) |
Chr 7:
93.05 – 93.2 Mb |
Chr 6:
3.69 – 3.76 Mb |
|
| PubMed search |
[1] |
[2] |
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The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis,[1] particularly with respect to bone formation and metabolism.[2][3][4]
CT works by activating the G-proteins Gs and Gq often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain.[5] It may also affect the ovaries in women and the testes in men.
The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY1 (CT + RAMP1), AMY2 (CT + RAMP2), and AMY3 (CT+ RAMP3).[6]
Contents
- 1 Interactions
- 2 References
- 3 Further reading
- 4 External links
Interactions[edit]
Calcitonin receptor has been shown to interact with Apolipoprotein B[7][8] and LRP1.[9]
References[edit]
- ^ Purdue BW, Tilakaratne N, Sexton PM (2002). "Molecular pharmacology of the calcitonin receptor". Recept. Channels 8 (3–4): 243–55. doi:10.1080/10606820213681. PMID 12529940.
- ^ Chambers TJ, Magnus CJ (1982). "Calcitonin alters behaviour of isolated osteoclasts". J. Pathol. 136 (1): 27–39. doi:10.1002/path.1711360104. PMID 7057295.
- ^ Dacquin R, Davey RA, Laplace C, Levasseur R, Morris HA, Goldring SR, Gebre-Medhin S, Galson DL, Zajac JD, Karsenty G (2004). "Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo". J. Cell Biol. 164 (4): 509–514. doi:10.1083/jcb.200312135. PMC 2171986. PMID 14970190.
- ^ Davey RA, Turner A, McManus JF, Chiu WS, Tjahyono F, Moore AJ, Atkins GJ, Anderson PH, Ma C, Glatt V, Maclean HE, Vincent C, Bouxsein M, Morris HA, Findlay DM, Zajac JD (2008). "Calcitonin Receptor Plays a Physiological Role to Protect Against Hypercalcemia in Mice". J Bone Miner Res 23 (8): 1182–1193. doi:10.1359/jbmr.080310. PMC 2680171. PMID 18348688.
- ^ senselab
- ^ "Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- ^ Zhang, Jianying; Herscovitz Haya (Feb 2003). "Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B". J. Biol. Chem. (United States) 278 (9): 7459–68. doi:10.1074/jbc.M207976200. ISSN 0021-9258. PMID 12397072.
- ^ Linnik, K M; Herscovitz H (Aug 1998). "Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state". J. Biol. Chem. (UNITED STATES) 273 (33): 21368–73. doi:10.1074/jbc.273.33.21368. ISSN 0021-9258. PMID 9694898.
- ^ Orr, Anthony Wayne; Pedraza Claudio E, Pallero Manuel Antonio, Elzie Carrie A, Goicoechea Silvia, Strickland Dudley K, Murphy-Ullrich Joanne E (Jun 2003). "Low density lipoprotein receptor–related protein is a calreticulin coreceptor that signals focal adhesion disassembly". J. Cell Biol. (United States) 161 (6): 1179–89. doi:10.1083/jcb.200302069. ISSN 0021-9525. PMC 2172996. PMID 12821648.
Further reading[edit]
- Pondel M (2001). "Calcitonin and calcitonin receptors: bone and beyond". International journal of experimental pathology 81 (6): 405–22. doi:10.1046/j.1365-2613.2000.00176.x. PMID 11298188.
- Gorn AH, Lin HY, Yamin M, et al. (1992). "Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line". J. Clin. Invest. 90 (5): 1726–35. doi:10.1172/JCI116046. PMC 443230. PMID 1331173.
- Albrandt K, Brady EM, Moore CX, et al. (1995). "Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene". Endocrinology 136 (12): 5377–84. doi:10.1210/en.136.12.5377. PMID 7588285.
- Egerton M, Needham M, Evans S, et al. (1995). "Identification of multiple human calcitonin receptor isoforms: heterologous expression and pharmacological characterization". J. Mol. Endocrinol. 14 (2): 179–89. doi:10.1677/jme.0.0140179. PMID 7619207.
- Nussenzveig DR, Mathew S, Gershengorn MC (1995). "Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor". Endocrinology 136 (5): 2047–51. doi:10.1210/en.136.5.2047. PMID 7720653.
- Nakamura M, Hashimoto T, Nakajima T, et al. (1995). "A new type of human calcitonin receptor isoform generated by alternative splicing". Biochem. Biophys. Res. Commun. 209 (2): 744–51. doi:10.1006/bbrc.1995.1562. PMID 7733946.
- Pérez Jurado LA, Li X, Francke U (1995). "The human calcitonin receptor gene (CALCR) at 7q21.3 is outside the deletion associated with the Williams syndrome". Cytogenet. Cell Genet. 70 (3–4): 246–9. doi:10.1159/000134044. PMID 7789182.
- Nussenzveig DR, Thaw CN, Gershengorn MC (1994). "Inhibition of inositol phosphate second messenger formation by intracellular loop one of a human calcitonin receptor. Expression and mutational analysis of synthetic receptor genes". J. Biol. Chem. 269 (45): 28123–9. PMID 7961748.
- Kuestner RE, Elrod RD, Grant FJ, et al. (1994). "Cloning and characterization of an abundant subtype of the human calcitonin receptor". Mol. Pharmacol. 46 (2): 246–55. PMID 8078488.
- Frendo JL, Pichaud F, Mourroux RD, et al. (1994). "An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid". FEBS Lett. 342 (2): 214–6. doi:10.1016/0014-5793(94)80503-2. PMID 8143880.
- Masi L, Becherini L, Gennari L, et al. (1998). "Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women". Biochem. Biophys. Res. Commun. 245 (2): 622–6. doi:10.1006/bbrc.1998.8445. PMID 9571205.
- Taboulet J, Frenkian M, Frendo JL, et al. (1999). "Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women". Hum. Mol. Genet. 7 (13): 2129–33. doi:10.1093/hmg/7.13.2129. PMID 9817931.
- Christopoulos G, Perry KJ, Morfis M, et al. (1999). "Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product". Mol. Pharmacol. 56 (1): 235–42. PMID 10385705.
- Nishikawa T, Ishikawa H, Yamamoto S, Koshihara Y (2000). "A novel calcitonin receptor gene in human osteoclasts from normal bone marrow". FEBS Lett. 458 (3): 409–14. doi:10.1016/S0014-5793(99)01176-X. PMID 10570950.
- Beaudreuil J, Taboulet J, Orcel P, et al. (2000). "Calcitonin receptor mRNA in mononuclear leucocytes from postmenopausal women: decrease during osteoporosis and link to bone markers with specific isoform involvement". Bone 27 (1): 161–8. doi:10.1016/S8756-3282(00)00305-7. PMID 10865224.
- Wada S, Yasuda S, Nagai T, et al. (2001). "Regulation of calcitonin receptor by glucocorticoid in human osteoclast-like cells prepared in vitro using receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factor". Endocrinology 142 (4): 1471–8. doi:10.1210/en.142.4.1471. PMID 11250927.
- Ogden CA, deCathelineau A, Hoffmann PR, et al. (2001). "C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells". J. Exp. Med. 194 (6): 781–95. doi:10.1084/jem.194.6.781. PMC 2195958. PMID 11560994.
- Nosaka Y, Tachi Y, Shimpuku H, et al. (2002). "Association of calcitonin receptor gene polymorphism with early marginal bone loss around endosseous implants". The International journal of oral & maxillofacial implants 17 (1): 38–43. PMID 11858573.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
External links[edit]
- "Calcitonin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Calcitonin receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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Cell surface receptor: G protein-coupled receptors
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Class A:
Rhodopsin like |
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| Class B: Secretin like |
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Orphan
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- GPR (56
- 64
- 97
- 98
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 123
- 124
- 125
- 126
- 128
- 133
- 143
- 144
- 155
- 157)
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Other
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- Brain-specific angiogenesis inhibitor (1
- 2
- 3)
- Cadherin (1
- 2
- 3)
- Calcitonin
- CALCRL
- CD97
- Corticotropin-releasing hormone (1
- 2)
- EMR (1
- 2
- 3)
- Glucagon (GR
- GIPR
- GLP1R
- GLP2R)
- Growth hormone releasing hormone
- PACAPR1
- GPR
- Latrophilin (1
- 2
- 3
- ELTD1)
- Methuselah-like proteins
- Parathyroid hormone (1
- 2)
- Secretin
- Vasoactive intestinal peptide (1
- 2)
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Class C: Metabotropic
glutamate / pheromone |
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Taste
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- TAS1R (1
- 2
- 3)
- TAS2R (1
- 3
- 4
- 5
- 7
- 8
- 9
- 10
- 13
- 14
- 16
- 19
- 20
- 30
- 31
- 38
- 39
- 40
- 41
- 42
- 43
- 45
- 46
- 50
- 60)
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|
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Other
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- Calcium-sensing receptor
- GABA B (1
- 2)
- Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8))
- GPRC6A
- GPR (156
- 158
- 179)
- RAIG (1
- 2
- 3
- 4)
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Class F:
Frizzled / Smoothened |
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Frizzled
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- Frizzled (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10)
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Smoothened
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Neuropeptide receptors
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| G protein-coupled receptor |
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Hormone receptors
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Hypothalamic
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CRH · FSH · LHRH · TRH · Somatostatin
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Pituitary
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Vasopressin (1A, 1B, 2) · Oxytocin · LHCG · TSH
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Other
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Atrial natriuretic factor (NPR3) · Calcitonin · Cholecystokinin (A, B) · VIP
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Opioid receptors
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Delta · Kappa · Mu · Nociceptin
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Other neuropeptide receptors
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Angiotensin · Bradykinin (B1, B2) / Tachykinin (TACR1) · Calcitonin gene-related peptide · Galanin · GPCR neuropeptide (B/W, FF, S, Y) · Neurotensin
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| Type I cytokine receptor |
GH · Prolactin
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| Enzyme-linked receptor |
Atrial natriuretic factor (NPR1, NPR2)
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| Other |
Sigma (1, 2)
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
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English Journal
- Inhibition of receptor activator of nuclear factor-κB ligand- or lipopolysaccharide-induced osteoclast formation by conophylline through downregulation of CREB.
- Koide N1, Kondo Y2, Odkhuu E3, Ulziisaikhan J3, Ukaji T4, Yokochi T3, Umezawa K4.
- Immunology letters.Immunol Lett.2014 Sep;161(1):31-7. doi: 10.1016/j.imlet.2014.04.006. Epub 2014 May 2.
- The effect of conophylline (CNP) on the receptor activator of nuclear factor-κB ligand (RANKL) or lipopolysaccharide (LPS)-induced osteoclast formation was studied in vitro using bone marrow-derived macrophages (BMMs) or the mouse macrophage-like cell line RAW 264.7. CNP inhibited RANKL-induced for
- PMID 24792671
- Hydrogen sulfide inhibits opioid withdrawal-induced pain sensitization in rats by down-regulation of spinal calcitonin gene-related peptide expression in the spine.
- Yang HY, Wu ZY, Bian JS.
- The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP).Int J Neuropsychopharmacol.2014 Sep;17(9):1387-95. doi: 10.1017/S1461145714000583. Epub 2014 May 13.
- Hyperalgesia often occurs in opioid-induced withdrawal syndrome. In the present study, we found that three hourly injections of DAMGO (a μ-opioid receptor agonist) followed by naloxone administration at the fourth hour significantly decreased rat paw nociceptive threshold, indicating the induction
- PMID 24824948
- Piezo2 expression in corneal afferent neurons.
- Bron R1, Wood RJ, Brock JA, Ivanusic JJ.
- The Journal of comparative neurology.J Comp Neurol.2014 Sep 1;522(13):2967-79. doi: 10.1002/cne.23560. Epub 2014 Apr 3.
- Recently, a novel class of mechanically sensitive channels has been identified and have been called Piezo channels. In this study, we explored Piezo channel expression in sensory neurons supplying the guinea pig corneal epithelium, which have well-defined modalities in this species. We hypothesized
- PMID 24549492
Japanese Journal
- Cetylpyridinium Chloride Inhibits Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Formation
- Zheng Ting,Chen Ling,Noh A Long Sae Mi,Yim Mijung
- Biological and Pharmaceutical Bulletin 36(4), 509-514, 2013
- … CPC inhibited receptor activator of nuclear factor (NF)-κB ligand (RANKL)-induced osteoclast formation in a dose-dependent manner without causing cytotoxicity. … The mRNA expression of cathepsin K, calcitonin receptor (CTR), and Prdm1 in osteoclasts was reduced by CPC. …
- NAID 130003361382
- Neurogenic Vascular Responses in Male Mouse Mesenteric Vascular Beds
- Fujiwara Hiroki,Hashikawa-Hobara Narumi,Wake Yoshihiro [他],TAKATORI Shingo,GODA Mitsuhiro,HIGUCHI Hiroshi,ZAMAMI Yoshito,TANGSUCHARIT Panot,KAWASAKI Hiromu
- Journal of pharmacological sciences 119(3), 260-270, 2012-07-20
- … Rat mesenteric arteries were maintained by both adrenergic vasoconstrictor nerves and calcitonin gene–related peptide (CGRP) vasodilator nerves. … In preparations with active tone, PNS (1 – 8 Hz) induced frequency-dependent vasodilation, which was inhibited by tetrodotoxin, capsaicin (CGRP depletor), and CGRP8-37 (CGRP-receptor antagonist). …
- NAID 10030987011
- The Mechanism of Calcitonin Gene-Related Peptide-Containing Nerve Innervation
- Hashikawa-Hobara Narumi,Hashikawa Naoya,Zamami Yoshito [他],TAKATORI Shingo,KAWASAKI Hiromu
- Journal of pharmacological sciences 119(2), 117-121, 2012-06-20
- … Calcitonin gene-related peptide (CGRP) is a major neurotransmitter and CGRP-containing primary sensory neurons play an important role in nociception and potent vasodilation. … Adrenomedullin, hepatocyte growth factor, and angiotensin II type 2 receptor activation induced CGRP nerve distribution in phenol-injured rats. …
- NAID 10030828329
Related Links
- The calcitonin (CT) is a polypeptide hormone first discovered by Coop and colleagues in the course of investigations to identify hormones that regulate serum levels of calcium (1). CT is able to decrease blood calcium levels by direct ...
- GoPubMed lists recent and important papers and reviews for calcitonin receptor-like(calcitonin receptor-like receptor) ... Adrenomedullin expression in the developing human fetal lung. New Gonzalez Bosc et al., Mexico. In J Investig ...
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