出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/07/02 18:24:16」(JST)
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (May 2012) |
Calcification is the process in which calcium salts build up in soft tissue, causing it to harden. Calcifications may be classified on whether there is mineral balance or not, and the location of the calcification.
Contents
|
Calcification of soft tissue (arteries, cartilage, heart valves, etc.) can be caused by Vitamin K deficiency or by poor calcium absorption due to a high calcium/vitamin D ratio. This can occur with or without a mineral imbalance.
Intake of excessive Vitamin D can cause Vitamin D poisoning and excessive intake of calcium from the intestine, when accompanied by a deficiency of vitamin K (perhaps induced by an anticoagulant such as warfarin). This can result in calcification of arteries and other soft tissue.[1] Such metastatic soft tissue calcification is mainly in tissues containing "calcium catchers" such as elastic fibres or sour mucopolysaccharides. These tissues especially include the lungs (pumice lung) and the aorta.[2]
Calcification can manifest itself in many ways in the body. Several conditions can be caused by poor calcium absorption:
Patterns of calcifications may indicate pathological processes. Laminated appearance suggests granulomatous disease while popcorn calcification indicates hamartoma. Malignant lesions may have stippled or eccentric lesions.
In a number of breast pathologies, calcium is often deposited at sites of cell death or in association secretions or hyalinized stroma, resulting in pathologic calcification. For example, small, irregular, linear calcifications may be seen, via mammography, in a ductal carcinoma-in-situ to produce visible radio-opacities. [3]
Treatment of high calcium/vitamin D ratio may most easily be accomplished by intake of more vitamin D if vitamin K is normal. Intake of too much vitamin D would be evident by anorexia, loss of appetite, or soft tissue calcification.
[3] Pathologic Basis of Disease, Robbins and Cotran; 8th edition, Elsevier 2009
|
This medical article is a stub. You can help Wikipedia by expanding it.
|
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
リンク元 | 「mineralize」「mineralization」「calcify」「石灰沈着」「calcified」 |
拡張検索 | 「mitral ring calcification」「mitral annular calcification」「striatopallidal calcification」 |
.