bubonic plague

• (突発性高熱と腸チフス様症状を呈する出血性炎症疾患)腺ペスト

関

plague、pneumonic plague

WordNet

1. any epidemic disease with a high death rate (同)pestilence, pest
2. a serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal (同)pestilence, pest, pestis
3. an annoyance; "those children are a damn plague"
4. any large scale calamity (especially when thought to be sent by God)
5. of or evidencing buboes; "bubonic plague"

PrepTutorEJDIC

1. (死亡率の高い)『疾病』,流行病,悪疫;《the ~》(特に)ペスト / (広い地域に及ぶ)(…の)災い,災難,(いやなものが)はびこること《+『of』+『名』》 / 《話》やっかいな人(もの),悩みの種 / (…で)…‘を'『悩ます』《+『名』+『with』+『名』(do『ing』)》

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/26 17:54:41」(JST)

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This article is about the disease in general. For information about the medieval European plague, see Black Death.

Bubonic plague
Classification and external resources
An inguinal bubo on the upper thigh of person infected with bubonic plague. Swollen lymph glands (buboes) often occur in the neck, armpit and groin (inguinal) regions of plague victims.
ICD-10	A20.0
ICD-9	020.0
DiseasesDB	14226
MedlinePlus	000596

Bubonic plague is a zoonotic disease, circulating mainly in fleas on small rodents, and is one of three types of bacterial infections caused by Yersinia pestis (formerly known as Pasteurella pestis), that belongs to the family Enterobacteriaceae. Without treatment, the bubonic plague kills about two thirds of infected humans within four days.

The term bubonic plague is derived from the Greek word βουβών, meaning "groin". Swollen lymph nodes (buboes) especially occur in the armpit and groin in persons suffering from bubonic plague. Bubonic plague was often used synonymously for plague, but it refers specifically to an infection that enters through the skin and travels through the lymphatics, as is often seen in flea-borne infections.

Bubonic plague—along with the septicemic plague and the pneumonic plague, which are the two other manifestations of Y. pestis—is commonly believed to be the cause of the Black Death that swept through Europe in the 14th century and killed an estimated 25 million people, or 30–60% of the European population. Around the Mediterranean Region, summers seemed to be the season when the disease took place. In northern Europe, the disease had its most frequent outbreaks in the autumn. Because the plague killed so many of the working population, wages rose with the demand for labor. Some historians have seen this as a turning point in European economic development.

Signs and symptoms

Acral necrosis of the nose, the lips, and the fingers and residual ecchymoses over both forearms in a patient recovering from bubonic plague that disseminated to the blood and the lungs. At one time, the patient's entire body was ecchymotic. Reprinted from Textbook of Military Medicine.

The most infamous symptom of bubonic plague is an infection of the lymph glands (lymphadenitis), which become swollen and painful and are known as buboes. After being transmitted via the bite of an infected flea, the Y. pestis bacteria become localized in an inflamed lymph node, where they begin to colonize and reproduce. Buboes associated with the bubonic plague are commonly found in the armpits, upper femoral, groin and neck region. Acral gangrene (i.e. of the fingers, toes, lips and nose), is another common symptom.

Due to its bite-based form of infection, the bubonic plague is often the first step of a progressive series of illnesses. Bubonic plague symptoms appear suddenly, usually 2–5 days after exposure to the bacteria. Symptoms include:

• Gangrene of the extremities such as toes, fingers, lips and tip of the nose.
• Chills
• General ill feeling (malaise)
• High fever (39 °C; 102 °F)
• Muscle cramps
• Seizures
• Smooth, painful lymph gland swelling called a bubo, commonly found in the groin, but may occur in the armpits or neck, most often at the site of the initial infection (bite or scratch)
• Pain may occur in the area before the swelling appears
• Skin color changes to a pink hue in some very extreme cases

Other symptoms include heavy breathing, continuous vomiting of blood (hematemesis), aching limbs, coughing, and extreme pain. The pain is usually caused by the decay or decomposition of the skin while the person is still alive. Additional symptoms include extreme fatigue, gastrointestinal problems, lenticulae (black dots scattered throughout the body), delirium, and coma.

Two other types of Y. pestis plague are pneumonic and septicemic. Pneumonic plague, unlike the bubonic or septicemic, induces coughing and is very infectious. It may spread person to person.

Cause

Oriental rat flea (Xenopsylla cheopis) infected with the Yersinia pestis bacterium which appears as a dark mass in the gut. The foregut of this flea is blocked by a Y. pestis biofilm; when the flea attempts to feed on an uninfected host, Y. pestis from the foregut is regurgitated into the wound, causing infection.

Bubonic plague is an infection of the lymphatic system, usually resulting from the bite of an infected flea, Xenopsylla cheopis (the rat flea). In very rare circumstances, as in the septicemic plague, the disease can be transmitted by direct contact with infected tissue or exposure to the cough of another human. The fleas are often found on rodents such as rats and mice, and seek out other prey when their rodent hosts die. The bacteria began its life harmlessly living in the digestive tracts of mammals. The ability to propagate was dependent only upon its ability to travel from mammal host to mammal host. The bacteria remained harmless to the flea, allowing the new host to spread the bacteria. The bacteria form aggregates in the gut of infected fleas and this results in the flea regurgitating ingested blood, which is now infected, into the bite site of a rodent or human host. Once established, bacteria rapidly spread to the lymph nodes and multiply.

Y. pestis bacilli can resist phagocytosis and even reproduce inside phagocytes and kill them. As the disease progresses, the lymph nodes can haemorrhage and become swollen and necrotic. Bubonic plague can progress to lethal septicemic plague in some cases. The plague is also known to spread to the lungs and become the disease known as the pneumonic plague. This form of the disease is highly communicable as the bacteria can be transmitted in droplets emitted when coughing or sneezing.

Diagnosis

Laboratory testing is required in order to diagnose and confirm plague. Ideally, confirmation is through the identification of Y. pestis culture from a patient sample. Confirmation of infection can be done by examining serum taken during the early and late stages of infection. To quickly screen for the Y. pestis antigen in patients, rapid dipstick tests have been developed for field use.

Treatment

Several classes of antibiotics are effective in treating bubonic plague. These include aminoglycosides such as streptomycin and gentamicin, tetracyclines (especially doxycycline), and the fluoroquinolone ciprofloxacin. Mortality associated with treated cases of bubonic plague is about 1–15%, compared to a mortality of 40–60% in untreated cases.

People potentially infected with the plague need immediate treatment and should be given antibiotics within 24 hours of the first symptoms to prevent death. Other treatments include oxygen, intravenous fluids, and respiratory support. People who have had contact with anyone infected by pneumonic plague are given prophylactic antibiotics. Using the broad-based antibiotic streptomycin has proven to be dramatically successful against the bubonic plague within 12 hours of infection.

History

First outbreak

Main article: Plague of Justinian

The first recorded epidemic ravaged the Byzantine Empire during the sixth century, and was named the Plague of Justinian after emperor Justinian I, who was infected but survived through extensive treatment. The epidemic is estimated to have killed approximately 50 million people in the Roman Empire alone. The historian Procopius wrote, in Volume II of History of the Wars, his encounter with the plague and the effect it had on the rising empire. In the spring of 542, the plague arrived in Constantinople, working its way from port city to port city and spreading through the Mediterranean, later migrating inland eastward into Asia Minor and west into Greece and Italy. Because the infectious disease spread inland by the transferring of merchandise through Justinian’s efforts in acquiring luxurious goods of the time and exporting supplies, his capital became the leading exporter of the bubonic plague. Procopius, in his work Secret History, declared that Justinian was a demon of an emperor who either created the plague himself or was being punished for his sinfulness.

Second outbreak

Main articles: Black Death and Second plague pandemic

Illustration of the Black Death from the Toggenburg Bible (1411)

In the Late Middle Ages (1340–1400) Europe experienced the most deadly disease outbreak in history when the Black Death, the infamous pandemic of bubonic plague, hit in 1347, killing a third of the human population. It is believed that society subsequently became more violent as the mass mortality rate cheapened life and thus increased warfare, crime, popular revolt, waves of flagellants, and persecution. The Black Death originated in or near China and spread from Italy and then throughout other European countries. Arab historians Ibn Al-Wardni and Almaqrizi believed the Black Death originated in Mongolia, and this was proven correct as Chinese records showed a huge outbreak in Mongolia in the early 1330s. Research published in 2002 suggests that it began in the spring of 1346 in the steppe region, where a plague reservoir stretches from the northwestern shore of the Caspian Sea into southern Russia. The Mongols had cut off the trade route, the Silk Road, between China and Europe which halted the spread of the Black Death from eastern Russia to Western Europe. The epidemic began with an attack that Mongols launched on the Italian merchant's last trading station in the region, Caffa in the Crimea. In the autumn of 1346, plague broke out among the besiegers and from them penetrated into the town. When spring arrived, the Italian merchants fled on their ships, unknowingly carrying the Black Death. Carried by the fleas on rats, the plague initially spread to humans near the Black Sea and then outwards to the rest of Europe as a result of people fleeing from one area to another.

There were many ethno-medical beliefs for avoiding the Black Death. One of the most famous was that by walking around with flowers in or around their nose people would be able to "ward off the stench and perhaps the evil that afflicted them". People believed the plague to be a punishment from God, and that the only way to be rid of the plague was to be forgiven by God. One such method used was to carve the symbol of the cross onto the front door of a house with the words "Lord have mercy on us".

Pistoia, a city in Italy, even went as far as enacting rules and regulations on the city and its inhabitants to keep it safe from the Black Death. The rules stated that no one was allowed to visit any plague-infected area and if they did they were not allowed back into the city. Some other rules were that no linen or woollen goods were to be imported into the city and no corpses were to be buried in the city. However, despite strict enforcement of the rules, the city eventually became infected. People who weren't infected with the plague gathered in groups and stayed away from the sick. They ate and drank with limited food and water and weren't even allowed oral communication because merely talking with one another increased the chance of passing on the disease.

While Europe was devastated by the disease, the rest of the world fared much better. In India, populations rose from a population of 91 million in 1300, to 97 million in 1400, to 105 million in 1500. Also sub-Saharan Africa remained largely unaffected by the plagues.

Bubonic plague victims in a mass grave from 1720–1721 in Martigues, France

The next few centuries were marked by several localized or regional outbreaks of lesser severity. The Great Plague of Seville (1647), the Great Plague of London (1665-1666), the Great Plague of Vienna (1679), Great Baltic plague (1708-1712.) and the Great Plague of Marseille (1720), were the last major outbreaks of the bubonic plague in Europe.

Traditional treatment

Main article: Miasma theory

Medieval doctors thought the plague was created by air corrupted by humid weather, decaying unburied bodies, and fumes produced by poor sanitation. The recommended treatment of the plague was a good diet, rest, and relocating to a non-infected environment so the individual could get access to clean air. This did help, but not for the reasons the doctors of the time thought. In actuality, because they recommended moving away from unsanitary conditions, people were, in effect, getting away from the rodents that harbored the fleas carrying the infection. However, this also helped to spread the infection to new areas previously non-infected.

Third outbreak

Main article: Third plague pandemic

Directions for searchers, Poona (now Pune) plague of 1897

The plague resurfaced for a third time in the mid-19th century. Like the two previous outbreaks, this one also originated in Eastern Asia. The initial outbreak occurred in China's Yunnan province in 1855. The disease remained localized in Southwest China for several years before spreading. In the city of Canton, beginning in March 1894, the disease killed 60,000 people in a few weeks. Daily water-traffic with the nearby city of Hong Kong rapidly spread the plague there, killing over 100,000 within two months.

From China, the plague spread to the Indian subcontinent around 1896. Over the next thirty years, India would lose 12.5 million people to the Bubonic plague. The disease was initially seen in port cities, beginning with Bombay (now Mumbai), but later emerged in Poona (now Pune), Kolkata, and Karachi (now in Pakistan). By 1899, the outbreak spread to smaller communities and rural areas in many regions of India. Overall, the impact of plague epidemics was greatest in western and northern India—in the provinces then designated as Bombay, Punjab, and the United Provinces—while eastern and southern India were not as badly affected. Ultimately, more than 12 million people died from the plague in India (including present day Pakistan and Bangladesh) and China alone.

In 1899, the plague reached the islands of Hawaii. The first evidence of the disease was found in Honolulu's Chinatown on Oahu. It was located very close to the island's piers, and rats in cargo ships from China were able to land on the Hawaiian islands unseen. As the rats, hosts for disease-carrying fleas, made their way deeper into the city, people started to fall ill. On December 12, 1899, the first case was confirmed. The Board of Health then quickly thought of ways to prevent the disease from spreading even further inland. Their solution was to burn down any buildings in Chinatown suspected of containing a source of the disease. On December 31, 1899, the board set the first fire. They had originally planned to burn only a few targeted buildings, and thought they could control the flames as each building was finished, but the fire got out of control, burning down untargeted neighboring buildings. The resulting fire caused many of Chinatown's homes to be destroyed and an estimated 4,000 people were left homeless.

From a series of images depicting the state of houses and 'slum' buildings in Sydney, Australia at the time of the 1900 outbreak and the cleansing and disinfecting operations which followed.

Australia suffered 12 major plague outbreaks between 1900 and 1925 originating from shipping. Research by Australian medical officers Thompson, Armstrong and Tidswell contributed to understanding the spread of Yersinia pestis to humans by fleas from infected rats.

According to the World Health Organization, the pandemic was considered active until 1959, when worldwide casualties dropped to 200 per year. In 1994, a plague outbreak in five Indian states caused an estimated 700 infections (including 52 deaths) and triggered a large migration of Indians within India as they tried to avoid the plague.

Biological warfare

Some of the earliest instances of biological warfare were said to have been products of the plague, as armies of the 14th century were recorded catapulting diseased corpses over the walls of towns and villages to spread the pestilence.

Later, plague was used during the Second Sino-Japanese War as a bacteriological weapon by the Imperial Japanese Army. These weapons were provided by Shirō Ishii's units and used in experiments on humans before being used on the field. For example, in 1940, the Imperial Japanese Army Air Service bombed Ningbo with fleas carrying the bubonic plague. During the Khabarovsk War Crime Trials, the accused, such as Major General Kiyashi Kawashima, testified that, in 1941, some 40 members of Unit 731 air-dropped plague-contaminated fleas on Changde. These operations caused epidemic plague outbreaks.

See also

• List of cutaneous conditions
• List of epidemics
• Miasma theory
• Plague doctor
• Plague doctor costume

Footnotes

References

• Echenberg, Myron J. (2007). Plague Ports: The Global Urban Impact of Bubonic Plague, 1894–1901. New York, NY: New York University Press. ISBN 0-8147-2232-6. OCLC 70292105. 
• Little, Lester K. (2007). "Life and Afterlife of the First Plague Pandemic." In: Little, Lester K. editor. (2007), Plague and the End of Antiquity: The Pandemic of 541–750. Cambridge University Press. (2007). ISBN 978-0-521-84639-4 (hardback); ISBN 978-0-521-71897-4 (paperback).
• McCormick, Michael (2007). "Toward a Molecular History of the Justinian Pandemic." In: Little, Lester K. editor. (2007), Plague and the End of Antiquity: The Pandemic of 541–750. Cambridge University Press. (2007). ISBN 978-0-521-84639-4 (hardback); ISBN 978-0-521-71897-4 (paperback).
• "Bubonic Plague Originated in China", Discovery News,1 November 2010. Retrieved on 6 December 2011.
• "Bubonic Plague Fire Destroyed Honolulu's Chinatown" Hawaii for Visitors. Retrieved on 6 December 2011.
• "Bubonic Plague and the Chinatown Fire Honolulu Advertiser, 7 July 2005. Retrieved on 6 December 2011.

Further reading

Books

• Alexander, John T. (2003, 1980). Bubonic Plague in Early Modern Russia: Public Health and Urban Disaster. Oxford, UK; New York, NY: Oxford University Press. ISBN 0-19-515818-0. OCLC 50253204. 
• Carol, Benedict (1996). Bubonic Plague in Nineteenth-Century China. Stanford, CA: Stanford University Press. ISBN 0-8047-2661-2. OCLC 34191853. 
• Biddle, Wayne (2002). A Field Guide to Germs (2nd Anchor Books ed.). New York: Anchor Books. ISBN 1-4000-3051-X. OCLC 50154403. 
• Little, Lester K. (2007). Plague and the End of Antiquity: The Pandemic of 541–750. New York, NY: Cambridge University Press. ISBN 978-0-521-84639-4. OCLC 65361042. 
• Rosen, William (2007). Justinian's Flea: Plague, Empire and the Birth of Europe. London, England: Viking Penguin. ISBN 978-0-670-03855-8. 
• Scott, Susan, and C. J. Duncan (2001). Biology of Plagues: Evidence from Historical Populations. Cambridge, UK; New York, NY: Cambridge University Press. ISBN 0-521-80150-8. OCLC 44811929. 
• Batten-Hill, David (2011). This Son of York. Kendal, England: David Batten-Hill. ISBN 978-1-78176-094-9. OCLC http://www.tsoy.co.uk. 

Articles

• Bartelloni, Peter J.; Marshall Jr, John D., Jr.; Cavanaugh, Dan C. (1973). "Clinical and serological responses to plague vaccine U.S.P". Military Medicine 138 (11): 720–722. PMID 4201988. Retrieved 18 January 2011. 
• Burmeister, R. W.; Tigertt, W. D.; Overholt, Edwin L. (1962). "Laboratory-acquired pneumonic plague". Annals of Internal Medicine 56 (5): 789–800. doi:10.7326/0003-4819-56-5-789. PMID 13874924. 
• Cavanaugh, Dan C.; Elisberg, BL; Llewellyn, CH; Marshall, JD; Rust, JH; Williams, JE; Meyer, KF (1974). "Plague immunization. V. Indirect evidence for the efficacy of plague vaccine". Journal of Infectious Diseases 129 (supplement): S37–S40. doi:10.1093/infdis/129.Supplement_1.S37. PMID 4596518. 
• Kool, J. L. (2005). "Risk of Person-to-Person Transmission of Pneumonic Plague". Clinical Infectious Diseases 40 (8): 1166–1172. doi:10.1086/428617. PMID 15791518. 

UpToDate Contents

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• 1. ペスト（Yersinia pestis感染症）の臨床症状、診断、および治療 clinical manifestations diagnosis and treatment of plague yersinia pestis infection
• 2. ペスト（Yersinia pestis感染症）の疫学、微生物学および病因 epidemiology microbiology and pathogenesis of plague yersinia pestis infection
• 3. 小児における鼠径部腫脹の評価 evaluation of inguinal swelling in children
• 4. 小児における頚部リンパ節炎の診断的アプローチおよび初期治療 diagnostic approach to and initial treatment of cervical lymphadenitis in children
• 5. 鳥インフルエンザの臨床症状および診断 clinical manifestations and diagnosis of avian influenza

English Journal

• BAC sequencing using pooled methods.

• Saski CA1, Feltus FA, Parida L, Haiminen N.
• Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2015;1227:55-67. doi: 10.1007/978-1-4939-1652-8_3.
• Shotgun sequencing and assembly of a large, complex genome can be both expensive and challenging to accurately reconstruct the true genome sequence. Repetitive DNA arrays, paralogous sequences, polyploidy, and heterozygosity are main factors that plague de novo genome sequencing projects that typica
• PMID 25239741

• On arsenic and plague.

• Tosetti F.
• Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.Clin Infect Dis.2014 Dec 15;59(12):1806-8. doi: 10.1093/cid/ciu704. Epub 2014 Sep 2.
• PMID 25182246

• Reasons for entering treatment reported by initially treatment-resistant patients with substance use disorders.

• Meyers RJ1, Roozen HG, Smith JE, Evans BE.
• Cognitive behaviour therapy.Cogn Behav Ther.2014 Dec;43(4):299-309. doi: 10.1080/16506073.2014.938358. Epub 2014 Jul 25.
• Many individuals with substance use disorders are resistant to entering formal treatment, despite the negative consequences that plague their own lives and the lives of concerned significant others (CSOs). Community Reinforcement and Family Training (CRAFT) has been developed as an effective strateg
• PMID 25059561

Japanese Journal

• Vaccination against bubonic and pneumonic plague

• TITBALL R. W.
• Vaccine 19, 4175-4184, 2001
• NAID 30006363761

• ENTOMOLOGICAL AND RODENT SURVEILLANCE IN PLAGUE-SUSPECTED AREAS DURING SEPTEMBER 1994 AND THEREAFTER

• KUMAR Kaushal,RAHMAN Syed Jamil-Ur,SHARMA Sushil Kumar,GILL Kuldip Singh,KATYAL Rakesh,KAUR Raminder,THOMAS Thekkevilayil George,BARUA Kalpana
• Japanese Journal of Medical Science and Biology 50(3), 97-111, 1997
• … Studies carried out in the states of Maharashtra, Gujarat, Uttar Pradesh and Union Territory of Delhi after the bubonic plague outbreak during 1994 revealed the presence of seven species of rodents, viz.<I>Rattus rattus, R. … These conditions were found to be highly supportive for bubonic plague transmission in the district. …
• NAID 130003953537

• The bacillus of bubonic plague

• KITASATO S.
• Lancet August 25, 428-430, 1894
• NAID 30006011916

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Related Pictures

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★リンクテーブル★

リンク元	「壊死性リンパ節炎」「腺ペスト」
関連記事	「plague」

「壊死性リンパ節炎」

　　[★]

英

necrotizing lymphadenitis

関

リンパ節炎

• necrotizing lymphadenitis is seen in a few specific infections(namely tularemia, bubonic plague, anthrax, and typhoid fever) and in Kikuchi lymphadenitis, arare noninfectous form. (Q book p.303)

「腺ペスト」

　　[★]

plague

英

bubonic plague

同

ペスト腺腫 pest bubo

関

ペスト

「plague」

　　[★]

• n.

• 疫病、伝染病、悪疫、(the ～)腺ペスト/ペスト
• 災害、禍、天災、天罰。のろい、災厄
• (害虫などの)異常発生、大襲来

• vt.