WordNet

the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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1. 高血圧における左室肥大の定義および病因 definition and pathogenesis of left ventricular hypertrophy in hypertension
2. 血管浮腫の概要：臨床的特徴、診断、およびマネージメント an overview of angioedema clinical features diagnosis and management
3. 後天性C1インヒビター欠損症：臨床症状、疫学、病因、および診断 acquired c1 inhibitor deficiency clinical manifestations epidemiology pathogenesis and diagnosis
4. 後天性C1インヒビター欠損症：管理および予後 acquired c1 inhibitor deficiency management and prognosis
5. 遺伝性血管浮腫：急性発作の治療 hereditary angioedema treatment of acute attacks

Nociceptive Sensitizers Are Regulated in Damaged Joint Tissues, Including Articular Cartilage, When Osteoarthritic Mice Display Pain Behavior.

Driscoll C1, Chanalaris A1, Knights C2, Ismail H1, Sacitharan PK1, Gentry C2, Bevan S2, Vincent TL1.
Arthritis & rheumatology (Hoboken, N.J.).Arthritis Rheumatol.2016 Apr;68(4):857-67. doi: 10.1002/art.39523.
OBJECTIVE: Pain is the most common symptom of osteoarthritis (OA), yet where it originates in the joint and how it is driven are unknown. The aim of this study was to identify pain-sensitizing molecules that are regulated in the joint when mice subjected to surgical joint destabilization develop OA-
PMID 26605536

The role of N-terminal and C-terminal Arg residues from BK on interaction with kinin B2 receptor.

Filippelli-Silva R, Martin RP, Rodrigues ES, Nakaie CR, Oliveira L, Pesquero JB, Shimuta SI.
Biological chemistry.Biol Chem.2016 Apr 1;397(4):305-14. doi: 10.1515/hsz-2015-0221.
Bradykinin (BK) is a nonapeptide important for several physiological processes such as vasodilatation, increase in vascular permeability and release of inflammatory mediators. BK performs its actions by coupling to and activating the B2 receptor, a family A G-protein coupled receptor. Using a strate
PMID 26584354

Differential effect of intranasally administrated kinin B1 and B2 receptor antagonists in Alzheimer's disease mice.

Asraf K, Torika N, Roasso E, Fleisher-Berkovich S.
Biological chemistry.Biol Chem.2016 Apr 1;397(4):345-51. doi: 10.1515/hsz-2015-0219.
An Increasing body of evidence supports a critical role of brain inflammation in the pathogenesis of Alzheimer's disease. A principal aspect of the brain immune response to inflammation is the activation of microglia. It has been shown that the kinin system is activated during brain inflammation and
PMID 26556847

Gangliosides stimulate bradykinin B2 receptors to promote calmodulin kinase ？-mediated neuronal differentiation

王子田彰夫
薬学雑誌 132(2), 195-199, 2012
… This labeling system, so-called reactive tag system, was successfully applied to the fluorescence imaging of tag-fused GPCRs such as bradykinin receptor (B2R) and acetylcholine receptor (m1AchR) expressing on HEK293 cells. …
NAID 130001872008

Involvement of Bradykinin in Trypsin-Induced Urinary Bladder Contraction in Cyclophosphamide-Treated Rats

Shimizu Naoko,Nakahara Tsutomu,Tsuda Yo [他],Mori Asami,Sakamoto Kenji,Ishii Kunio
Biological and Pharmaceutical Bulletin 34(7), 1122-1125, 2011
… Protease-activated receptor-2 (PAR-2) is activated by serine proteases, such as trypsin and mast cell tryptase. … In the present study, we examined the role of bradykinin in contractions induced by trypsin and the PAR-2 agonist 2-furoyl-LIGRL-NH2 in urinary bladders isolated from control or cyclophosphamide (CYP)-induced cystitis rats. …
NAID 130000738107