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Identification of bovine leukocyte antigen class II haplotypes associated with variations in bovine leukemia virus proviral load in Japanese Black cattle.

Miyasaka T, Takeshima SN, Jimba M, Matsumoto Y, Kobayashi N, Matsuhashi T, Sentsui H, Aida Y.SourceViral Infectious Diseases Unit, RIKEN, Wako, Saitama, Japan; School of Veterinary Medicine, Nihon University, Fujisawa, Kanagawa, Japan.
Tissue antigens.Tissue Antigens.2012 Dec 6. doi: 10.1111/tan.12041. [Epub ahead of print]
Bovine leukemia virus (BLV) is the etiological agent of enzootic bovine leukosis, which is the most common neoplastic disease of cattle. Bovine leukocyte antigen (BoLA) is strongly involved in the subclinical progression of BLV infections. Recent studies show that the BoLA-DRB3 gene might play a dir
PMID 23216331

BLV-CoCoMo-qPCR: a useful tool for evaluating bovine leukemia virus infection status.

Jimba M, Takeshima SN, Murakami H, Kohara J, Kobayashi N, Matsuhashi T, Ohmori T, Nunoya T, Aida Y.SourceViral Infectious Diseases Unit, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. aida@riken.jp.
BMC veterinary research.BMC Vet Res.2012 Sep 21;8:167. doi: 10.1186/1746-6148-8-167.
ABSTRACT:BACKGROUND: Bovine leukemia virus (BLV) is associated with enzootic bovine leukosis, which is the most common neoplastic disease of cattle. BLV infects cattle worldwide, imposing a severe economic impact on the dairy cattle industry. Recently, we developed a new quantitative real-time polym
PMID 22995575

Overexpression of interleukin 2 receptor, thymidine kinase and immunoglobulin-associated alpha-1 messenger RNA in a clinical case of enzootic bovine leukosis.

Tawfeeq MM, Tagawa M, Itoh Y, Sugimoto K, Kobayashi Y, Inokuma H.SourceDepartment of Clinical Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080-8555, Japan.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science.J Vet Med Sci.2012 Sep;74(9):1203-6. Epub 2012 May 14.
A 49-month-old Holstein cow with anorexia, tachypnea, enlarged peripheral lymph nodes, and difficulty standing up was suspected of bovine leukosis. Hematological examination revealed lymphocytosis with the presence of neoplastic cells. Increased total lactate dehydrogenase (LDH) activity, isozymes o
PMID 23037779

IWAMA Yoko,INOMATA Takateru,ISHIKAWA Yoshiharu,KADOTA Koichi
Japan Agricultural Research Quarterly: JARQ 47(1), 103-107, 2013
… Lymphoid neoplasms in 17 cattle having tested positive for bovine leukosis virus (BLV) were investigated by histology and immunohistochemistry. … Most lymphoma cases associated with BLV are classified as pleomorphic, and neoplasms termed enzootic leukosis should be diagnosed based on tumor cell morphology. …
NAID 130003377750

Utility of Serum Thymidine Kinase Activity Measurements for Cases of Bovine Leukosis with Difficult Clinical Diagnoses

TAWFEEQ Mohammad Monir,MIURA Saori,HORIUCHI Noriyuki,KOBAYASHI Yoshiyasu,FURUOKA Hidefumi,INOKUMA Hisashi
Journal of Veterinary Medical Science, 2013
… This study evaluated the clinical usefulness of serum thymidine kinase (TK) activity for diagnosing bovine leukosis cases for which clinical diagnosis was difficult ('BL with difficult diagnosis'). …
NAID 130003362197

Evaluation of Gene Expression in Peripheral Blood Cells as a Potential Biomarker for Enzootic Bovine Leukosis

TAWFEEQ Mohammad Monir,HORIUCHI Noriyuki,KOBAYASHI Yoshiyasu,FURUOKA Hidefumi,INOKUMA Hisashi
Journal of Veterinary Medical Science, 2013
… Expression of six selective genes in peripheral blood cells was evaluated as diagnostic biomarkers for enzootic bovine leukosis (EBL) by using 10 EBL and 15 clinically healthy cattle. …
NAID 130003362188