WordNet

remove the bones from; "bone the turkey before roasting it" (同)debone
the porous calcified substance from which bones are made (同)osseous_tissue
consisting of or made up of bone; "a bony substance"; "the bony framework of the body"
a shade of white the color of bleached bones (同)ivory, pearl, off-white
rigid connective tissue that makes up the skeleton of vertebrates (同)os
a decrease in size of an organ caused by disease or disuse (同)wasting, wasting away
undergo atrophy; "Muscles that are not used will atrophy"
any weakening or degeneration (especially through lack of use) (同)withering
having bones as specified; "his lanky long-boned body"
having had the bones removed; "a boneless rib roast"; "a boned (or deboned) fish" (同)deboned
a percussion instrument consisting of a pair of hollow pieces of wood or bone (usually held between the thumb and fingers) that are made to click together (as by Spanish dancers) in rhythm with the dance (同)castanets, clappers, finger cymbals

PrepTutorEJDIC

〈C〉骨 / 〈U〉骨を作っている物質,骨質 / 《複数形で》骨格;死骸(がい) / 〈魚など〉‘の'骨を取る
(栄養不良などによる)萎縮(いしゅく) / (一般的に)衰退,退化 / 萎縮する,衰退する / …'を'萎縮させる,衰退させる
(魚など)骨を取り除いた / (衣服が)(コルセットなどで)骨で張りをつけた[ような]

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1. 小児および思春期における良性骨腫瘍の概要 overview of benign bone tumors in children and adolescents
2. 骨パジェット病の臨床症状および診断 clinical manifestations and diagnosis of paget disease of bone
3. 小児癌患者の骨に関する問題 bone problems in childhood cancer patients
4. 脊髄性筋萎縮症 spinal muscular atrophy
5. 成人における複合性局所疼痛症候群の病因、臨床症状、および診断 etiology clinical manifestations and diagnosis of complex regional pain syndrome in adults

English Journal

Development of new metallic alloys for biomedical applications.

Niinomi M, Nakai M, Hieda J.SourceInstitute for Materials Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan. Electronic address: niinomi@imr.tohoku.ac.jp.
Acta biomaterialia.Acta Biomater.2012 Nov;8(11):3888-903. doi: 10.1016/j.actbio.2012.06.037. Epub 2012 Jul 15.
New low modulus β-type titanium alloys for biomedical applications are still currently being developed. Strong and enduring β-type titanium alloy with a low Young's modulus are being investigated. A low modulus has been proved to be effective in inhibiting bone atrophy, leading to good bone remode
PMID 22765961

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia-like Syndrome Without Bone Involvement.

Guerreiro RJ, Lohmann E, Brás JM, Gibbs JR, Rohrer JD, Gurunlian N, Dursun B, Bilgic B, Hanagasi H, Gurvit H, Emre M, Singleton A, Hardy J.AbstractOBJECTIVE To identify new genes and risk factors associated with frontotemporal dementia (FTD). Several genes and loci have been associated with different forms of FTD, but a large number of families with dementia do not harbor mutations in these genes. DESIGN Whole-exome sequencing and whole-genome genotyping were performed in all patients. Genetic variants obtained from whole-exome sequencing were integrated with the data obtained from whole-genome genotyping. SETTING Database of the Behavioral Neurology Outpatient Clinic of the Department of Neurology, Istanbul Faculty of Medicine, Istanbul, Turkey. PATIENTS Forty-four Turkish patients with an FTD-like clinical diagnosis were included in the study. Relatives were screened when appropriate. MAIN OUTCOME MEASURE Mutations in the triggering receptor expressed on myeloid cells 2 gene (TREM2). RESULTS In 3 probands with FTD-like disease, we identified different homozygous mutations in TREM2 that had previously been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). None of these 3 patients had a typical clinical presentation of PLOSL: they presented with behavioral change and subsequent cognitive impairment and motor features but without any bone cysts or bone-associated phenotypes. Imaging showed white matter abnormalities as well as frontal atrophy in all 3 patients. CONCLUSIONS Our results show that TREM2 is responsible for an unexpectedly high number of dementia cases in our cohort, suggesting that this gene should be taken into account when mutations in other dementia genes are excluded. Even for complex syndromes such as dementia, exome sequencing has proven to be a rapid and cost-effective tool to identify genetic mutations, allowing for the association of clinical phenotypes with unexpected molecular underpinnings.
Archives of neurology.Arch Neurol.2012 Oct 8:1-7. doi: 10.1001/archneurol.2013.579. [Epub ahead of print]
OBJECTIVE To identify new genes and risk factors associated with frontotemporal dementia (FTD). Several genes and loci have been associated with different forms of FTD, but a large number of families with dementia do not harbor mutations in these genes. DESIGN Whole-exome sequencing and whole-genome
PMID 23044491

Japanese Journal

橈骨遠位端骨折後のビスホスホネート早期投与は廃用性萎縮を予防できるか : DXA法による第2中手骨骨密度を用いた検討

金谷幸一,島本周治,加藤義治
臨床整形外科 49(1), 53-57, 2014-01
NAID 40019924158

Diabetic Complications in Obese Type 2 Diabetic Rat Models

KATSUDA Yoshiaki,OHTA Takeshi,MIYAJIMA Katsuhiro [他],Kemmochi Yusuke,Sasase Tomohiko,Tong Bin,Shinohara Masami,Yamada Takahisa
Experimental Animals 63(2), 121-132, 2014
… Pancreatic changes with progression of diabetes were classified into early changes, such as islet hypertrophy and degranulation of β cells, and degenerative changes, such as islet atrophy and fibrosis of islet with infiltration of inflammatory cells. …
NAID 130003391622

Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism

Sato Mari,Asada Noboru,Kawano Yuko,Wakahashi Kanako,Minagawa Kentaro,Kawano Hiroki,Sada Akiko,Ikeda Kyoji,Matsui Toshimitsu,Katayama Yoshio
Cell metabolism 18(5), 749-758, 2013-11-05
… Osteocytes act as mechanosensors to control local bone volume. … We show that ablation of osteocytes in mice (osteocyte-less [OL] mice) leads to severe lymphopenia, due to lack of lymphoid-supporting stroma in both the bone marrow and thymus, and complete loss of white adipose tissues. … These effects were reversed when osteocytes were replenished within the bone. …
NAID 120005365920