blastoma

真性腫瘍 　

WordNet

1. a tumor composed of immature undifferentiated cells (同)blastocytoma, embryonal carcinosarcoma

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/20 17:27:08」(JST)

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A blastoma is a type of cancer, more common in children, that is caused by malignancies in precursor cells, often called blasts. Examples are nephroblastoma, medulloblastoma and retinoblastoma. The suffix "-blastoma" is used to imply a tumor of primitive, incompletely differentiated (or precursor) cells, i.e., chondroblastoma is composed of cells resembling the precursor of chondrocytes.

Blastomas usually occur in children.

Molecular biology and treatment

Many types of blastoma have been linked to a mutation in tumor suppressor genes. For example, pleuropulmonary blastomas have been linked to a mutation of the coding for p53. However, the mutation which allows proliferation of incompletely differentiated cells can vary from patient to patient and a mutation can alter the prognosis. In the case of retinoblastoma, patients carry a visibly abnormal karyotype, with a loss of function mutation on a specific band of chromosome 13. This recessive deletion on the rb gene is also associated with other cancer types and must be present on both alleles, for a normal cell to progress towards malignancy. Thus, in the case of common blastomas, such as retinoblastomas, a practitioner may go directly into treatment, but in the case of rarer, more-genetically-linked blastomas, practitioners may karyotype the patient before proceeding with treatment.^{[citation needed]}

Types of blastomas

• Hepatoblastoma
• Medulloblastoma
• Nephroblastoma
• Neuroblastoma
• Pancreatoblastoma
• Pleuropulmonary blastoma
• Retinoblastoma
• Glioblastoma Multiforme

References

UpToDate Contents

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• 1. 先天性肺気道（嚢胞性腺腫様）形成異常 congenital pulmonary airway cystic adenomatoid malformation
• 2. 肺悪性腫瘍の病理 pathology of lung malignancies
• 3. 小児および思春期の横紋筋肉腫：疫学、病理、および分子学的病因 rhabdomyosarcoma in childhood and adolescence epidemiology pathology and molecular pathogenesis
• 4. 卵巣の性索間質腫瘍：セルトリ・間質細胞腫瘍 sex cord stromal tumors of the ovary sertoli stromal cell tumors
• 5. 呼気中一酸化窒素の分析および適用 exhaled nitric oxide analysis and applications

English Journal

• Novel DICER1 mutation as cause of multinodular goiter in children.

• Darrat I, Bedoyan JK, Chen M, Schuette JL, Lesperance MM.SourceDivision of Pediatric Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan.
• Head & neck.Head Neck.2013 Jun 1. doi: 10.1002/hed.23250. [Epub ahead of print]
• BACKGROUND: The aim of this report was to present a rare case of an adolescent with multinodular goiter (MNG) found to have a DICER1 mutation.METHODS AND RESULTS: The methodology includes a presentation and discussion of a chart review including endocrine hormone tests, thyroid ultrasound, and genet
• PMID 23728841

• Treatment of high risk Sertoli-Leydig cell tumors of the ovary using a gonadotropin releasing hormone (GnRH) analog.

• Lashkari HP, Nash R, Albanese A, Okoye B, Millar R, Pritchard-Jones K.SourceThe Royal Marsden Hospital NHS Trust, Sutton, Surrey, UK.
• Pediatric blood & cancer.Pediatr Blood Cancer.2013 Jun;60(6):E16-8. doi: 10.1002/pbc.24382. Epub 2012 Nov 28.
• Sertoli-Leydig cell tumors are rare ovarian neoplasms. We report two unusual cases with bilateral SLCTs suggesting evidence of genetic predisposition and at high risk of recurrence. To reduce this risk, we exploited the use of GnRH analog to lower gondadotropin and potentially directly inhibit the t
• PMID 23193086

• DICER1 Syndrome: A New Cancer Syndrome.

• Schultze-Florey RE, Graf N, Vorwerk P, Koscielniak E, Schneider DT, Kratz CP.SourceKlinik für Pädiatrische Hämatologie und Onkologie, Medizinische Hochschule, Hannover, Germany.
• Klinische Padiatrie.Klin Padiatr.2013 May;225(3):177-178. Epub 2013 Apr 26.
• Recently, germline mutations of DICER1 have been identified in patients with rare neoplasms suggesting the existence of a newly discovered cancer prone syndrome. Initially, DICER1 mutations were identified in patients with familial pleuropulmonary blastoma. Subsequently, additional manifestations of
• PMID 23625684

Japanese Journal

• 初発時に髄外造血による多発皮下腫瘤を合併した慢性骨髄性白血病

• 臨床血液 57(4), 461-466, 2016
• NAID 130005150507

• 末梢血幹細胞移植を併用した大量化学療法を含む集学的治療施行後，腺腫様甲状腺腫を発症した胸膜肺芽腫の1例

• 日本小児外科学会雑誌 51(7), 1190-1197, 2015
• NAID 130005114217

• 小児胸膜肺芽腫の2切除例

• 日本呼吸器外科学会雑誌 28(5), 662-667, 2014
• NAID 130004678897

Related Links

• Blastoma | definition of blastoma by Medical dictionary

blastoma [blas-to´mah] (pl. blastomas, blasto´mata) A neoplasm composed of embryonic cells derived from the blastema of an organ or tissue. adj., adj blasto´matous. blas·to·ma (blas-tō'mă), A neoplasm composed chiefly or entirely ...

• Blastoma Symptoms, Diagnosis, Treatments and Causes ...

Blastoma information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis. ... Blastoma: Introduction Blastoma: A type of tumor that originates from precursor ...

Related Pictures

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★リンクテーブル★

リンク元	「芽腫」「真性腫瘍」「芽細胞腫」
拡張検索	「familial retinoblastoma」「hereditary retinoblastoma」「glioblastoma multiforme」

「芽腫」

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英

blastoma

関

芽細胞腫

「真性腫瘍」

　　[★]

英

blastoma, true tumor

「芽細胞腫」

　　[★]

英

blastoma

関

芽腫

「familial retinoblastoma」

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家族性網膜芽細胞腫

関

hereditary retinoblastoma、retinoblastoma、sporadic retinoblastoma

「hereditary retinoblastoma」

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遺伝性網膜芽細胞腫

関

familial retinoblastoma、retinoblastoma、sporadic retinoblastoma

「glioblastoma multiforme」

　　[★] 膠芽腫。多形膠芽腫