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a heavy brittle diamagnetic trivalent metallic element (resembles arsenic and antimony chemically); usually recovered as a by-product from ores of other metals (同)Bi, atomic number 83

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蒼鉛(そうえん)(金属元素;化学記号はBi)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/18 21:59:00」(JST)

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Bismuth subgallate, with a chemical formula C₇H₅BiO₆, is commonly used to treat malodor by deodorizing flatulence and stools. In the United States it is the active ingredient in Devrom (internal deodorant), an over-the-counter FDA-approved medicine. Also, it has been used to treat Helicobacter pylori infection and is used in wound therapy. As an internal deodorant, it is commonly used by individuals who have had ostomy surgery, bariatric surgery, fecal incontinence, and irritable bowel syndrome.^[1]

It can cause darkening of the tongue and stools, which is temporary and harmless. In 1974, a reversible encephalopathy was noted and examined in four colon cancer patients taking bismuth subgallate after abdominoperineal resection.^[2]

Also, a double blind study in 1974 reported its effectiveness as a flatulence/stool deodorant in ileostomy patients.^[3]

Safety[edit source | edit]

It is classified as nontoxic.^{[by whom?]}

External links[edit source | edit]

American Cancer Society: Ileostomy Guide [1]
Cleveland Clinic-Having an Ileostomy– A Primer for New Ostomates [2]
United Ostomy Association of America-Ileostomy Guide [3]
The Ostomy Files:The Issue of Oral Medications and a Fecal Ostomy [4]
Devrom website [5]
Gulp: Adventures on the Alimentary Canal by Mary Roach [6]

References[edit source | edit]

^ Gorbach S. L. (1990). "Bismuth therapy in gastrointestinal diseases". Gastroenterology 99 (3): 863–75. PMID 2199292.
^ Burns R., Thomas D. W., Barron V. J. (1974). "Reversible encephalopathy possibly associated with bismuth subgallate ingestion". British Medical Journal 9 (1): 220–3. PMC 1633100. PMID 4818163.
^ Sparberg M. (1974). "Correspondence: Bismuth subgallate as an effective means for the control of ileostomy odor: a double blind study". Gastroenterology 66 (3): 476. PMID 4813513.

UpToDate Contents

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1. 人工肛門造設または回腸瘻造設患者の管理 management of patients with a colostomy or ileostomy
2. 抗潰瘍剤の薬理学 pharmacology of antiulcer medications
3. ヘリコバクターピロリ菌の治療レジメン treatment regimens for helicobacter pylori
4. 腸内ガスと膨満 intestinal gas and bloating
5. 熱傷の局所治療：外用抗菌薬と被覆材 local treatment of burns topical antimicrobial agents and dressings

English Journal

In vitro antibacterial activity and cytocompatibility of bismuth doped micro-arc oxidized titanium.

Lin DJ, Tsai MT, Shieh TM, Huang HL, Hsu JT, Ko YC, Fuh LJ.SourceDepartment of Dental Hygiene, China Medical University, Taichung, Taiwan.
Journal of biomaterials applications.J Biomater Appl.2013 Jan;27(5):553-63. doi: 10.1177/0885328211414942. Epub 2011 Sep 16.
Chemical manipulations of the implant surface produce a bactericidal feature to prevent infections around dental implants. Despite the successful use of bismuth against mucosal and dermis infections, the antibacterial effect of bismuth in the oral cavity remains under investigation. The aim of this
PMID 21926149

[Clinical study on topical bismuth subgallate/borneol (Suile) dressing for treatment of diabetic foot ulcers].

Wang F, Yuan N, Wang Y, Wang C, Wang A, Yu T, Liu G, Xu Z, Ran X.SourceDiabetic Foot Care Center, Department of Endocrinology, West China Hospital, Sichuan University, Chengdu Sichuan 610041, PR China.
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery.Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi.2012 Aug;26(8):955-60.
OBJECTIVE: To evaluate the efficacy and safety of Bismuth Subgallate/Borneol (Suile) (BSB) dressing in the treatment of diabetic foot ulcers.METHODS: A two-center, randomized controlled parallel-group comparison study was conducted. Between September 2005 and November 2006, 35 patients with nonheali
PMID 23012931

Bismuth subgallate as a topical haemostatic agent at the palatal wounds: a histologic study in dogs.

Kim SH, Tramontina VA, Papalexiou V, Luczsyzyn SM, De Lima AA, do Prado AM.SourceDepartment of Periodontology, Pontifical Catholic University of Parana, School of Dentistry, Curitiba, Brazil. sung.kim@pucpr.br
International journal of oral and maxillofacial surgery.Int J Oral Maxillofac Surg.2012 Feb;41(2):239-43. doi: 10.1016/j.ijom.2011.12.002. Epub 2011 Dec 29.
This study evaluated the early recovery process of the palatal wounds of dogs using bismuth subgallate. Five healthy adult male dogs underwent eight 5-mm partial-thickness punch biopsies in two paired columns on the palatal mastigatory mucosa. For the haemostasis, one side received moistened gauze p
PMID 22209184

Japanese Journal

ICP-MSによる環境試料中のビスマス定量とビスマス化合物の細胞毒性に関する基礎的検討

小林淳,寺田宙,杉山英男 [他],松川岳久,千葉百子,横山和仁
分析化学 = Japan analyst 60(4), 357-362, 2011-04-05
… We examined both bismuth content levels in some environmental water samples (tapwater, bottled drinking water and slag obtained by sewage disposal) by inductively coupled plasma mass spectrometry (ICP-MS) and cultured cell toxicity of their compounds by the MTT assay. … On the other hand, concerning cell toxicity, the subgallate and free gallic acid affected the lives of cultured cells. …
NAID 10028107131

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リンク元	「次没食子酸ビスマス」
関連記事	「bismuth」

「次没食子酸ビスマス」

Bismuth subgallate
Systematic (IUPAC) name
	2,7-dihydroxy-1,3,2-benzodioxabismole-5-carboxylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	OTC (US)
Identifiers
CAS number	99-26-3
ATC code	A07BB
PubChem	CID 16682999
ChemSpider	10607905
UNII	YIW503MI7V
ChEBI	CHEBI:31292
Chemical data
Formula	C7H5BiO6
Mol. mass	394.091 g·mol−1
	SMILES OC(=O)c2cc1O[Bi](O)Oc1c(O)c2;
	InChI InChI=1S/C7H6O5.Bi.H2O/c8-4-1-3(7(11)12)2-5(9)6(4)10;;/h1-2,8-10H,(H,11,12);;1H2/q;+3;/p-3 ; Key:JAONZGLTYYUPCT-UHFFFAOYSA-K ;
Physical data
Density	1.1 g/cm³
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