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a complex consisting of an organic base in association with hydrogen chloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/15 03:04:40」(JST)

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Betazole (also known as ametazole) is a histamine H₂ receptor agonist. Betazole hydrochloride is known as gastramine and histalog.

It has been used as a gastric stimulant to test for maximal production of gastric secretion activity.^[1] The test can be used in diagnosis of diseases such as Zollinger-Ellison syndrome where there is excess acid production, in this case driven by over production of gastrin. The volume of acid secretion is measured following administration of betazole, diagnosis being secretion greater than 60% of the maximal acid secretion following betazole stimulation. This procedure can lead to complications and should be avoided in subjects with coronary artery disease.^[2] It is also used in diagnosis of gastritis in association with a test for secretin activity.

Betazole is used as a stimulant in preference to histamine because of its specificity for the H₂ receptor and its advantage of not generating the undesirable side effects that histamine would induce. It therefore does not require concomitant use of antihistaminic compounds to block the actions of histamine at other histamine receptor types.

Its action in stimulating histamine release can be of use when testing the effectiveness of H₂ receptor blocking drugs such as nizatidine.^[3]

References

^ Wruble LD Cummins AJ Goldenberg J Schapiro H (1967). "The effect of intravenous histalog on gastric secretion in man". Digestive Diseases and Sciences 12 (11): 1087–1090. doi:10.1007/BF02233873. PMID 6057052.
^ Stoller JL Holubitsky IB Harrison RC Munro AI (1970). "Complications of the histalog test of gastric acid secretion". Digestive Diseases and Sciences 15 (7): 647–651. doi:10.1007/BF02236024. PMID 4951403.
^ Hammond JB, Offen WW (1988). "Effect of nizatidine and cimetidine on betazole-stimulated gastric secretion of normal subjects: comparison of effects on acid, water, and pepsin.". Am J Gastroenterol. 83 (1): 32–6. PMID 2892392.

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English Journal

Gastric secretory and hormonal patterns in end-stage chagasic achalasia.

da Rocha JR1, Ribeiro U, Cecconello I, Sallum RA, Takeda F, Nasi A, Szachnowicz S.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E.Dis Esophagus.2009;22(7):606-10. doi: 10.1111/j.1442-2050.2009.00961.x. Epub 2009 Mar 17.
Achalasia surgical treatment alters the esophagogastric junction anatomy (cardiomyotomy plus fundoplication or esophagectomy and gastric pull-up), thus favoring a certain degree of gastroesophageal reflux. Gastric secretory and hormonal functioning is not completely known in chagasic patients. The a
PMID 19302218

[Influences of respiratory frequency on breathing mechanics during artificial ventilation in man and animal].

Imai T1.
[Hokkaido igaku zasshi] The Hokkaido journal of medical science.Hokkaido Igaku Zasshi.1989 Sep;64(5):597-605.
Effects of respiratory frequency on breathing mechanics were examined on 11 surgical patients during artificial ventilation with inhalation of nitrous oxide, oxygen and halothane (GOF). When the respiratory frequency was increased stepwise from 10 to 30/min, the total compliance was significantly re
PMID 2591872

Effects of cyclic nucleotides, betazole hydrochloride and acetylcholine on pepsinogen secretion from isolated rabbit gastric mucosa.

Noguchi Y, Ito M, Katsumi K, Yokoyama Y, Yasue N, Miyamoto T, Joh T, Takeuchi T.
Gastroenterologia Japonica.Gastroenterol Jpn.1986 Apr;21(2):129-34.
The effects of dibutyryl cyclic AMP (db-cAMP), dibutyryl cyclic GMP (db-cGMP), betazole hydrochloride (betazole) and acetylcholine (ach.) on pepsinogen secretion from isolated rabbit gastric mucosa were studied using an organ culture system. The 10(-3) M db-cAMP, but not db-cGMP of any concentration
PMID 3011576

Japanese Journal

Experimental study of the effects of exogenous epinephrine on the mechanism of gastric acid secretion.

矢吹清隆
日本消化器病学会雑誌 84(9), 1740-1748, 1987
… To clarify the role of the sympathoadrenal system in gastric acid secretion, the author evaluated the effects of epinephrine on gastric acid secretion during stimulation with tetragastrin, betazole hydrochloride, bethanechol, and bombesion in dogs with a total gastric fistula. … Epinephrine administration reduced gastric acid secretion dose-dependently during stimulation with these agents except betazole hydrochloride. …
NAID 130001066254

Related Pictures

★リンクテーブル★

リンク元	「ベタゾール」「塩酸ベタゾール」
関連記事	「betazole」「hydrochloride」

「ベタゾール」

Betazole
Names
	IUPAC name 2-(1H-pyrazol-5-yl)ethanamine
Identifiers
CAS Number	105-20-4
ChEBI	CHEBI:59170
ChEMBL	ChEMBL1201323
ChemSpider	7455
DrugBank	DB00272
IUPHAR/BPS	7126
Jmol 3D model	Interactive image
PubChem	7741
UNII	1C065P542O
	InChI InChI=1S/C5H9N3/c6-3-1-5-2-4-7-8-5/h2,4H,1,3,6H2,(H,7,8) Key: JXDFEQONERDKSS-UHFFFAOYSA-N ; InChI=1/C5H9N3/c6-3-1-5-2-4-7-8-5/h2,4H,1,3,6H2,(H,7,8) Key: JXDFEQONERDKSS-UHFFFAOYAY ;
	SMILES n1ccc(n1)CCN ;
Properties
Chemical formula	C5H9N3
Molar mass	111.145 g/mol
Pharmacology
ATC code	V04CG02 (WHO)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references