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- betazole hydrochloride
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/04/09 07:24:07」(JST)
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Not to be confused with Betaxolol, a selective beta1-adrenergic receptor antagonist.
Betazole |
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IUPAC name
2-(2H-Pyrazol-3-yl)ethanamine
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Identifiers |
CAS number |
105-20-4 Y |
PubChem |
7741 |
ChemSpider |
7455 Y |
UNII |
1C065P542O Y |
ChEBI |
CHEBI:59170 Y |
ChEMBL |
CHEMBL1201323 N |
ATC code |
V04CG02 |
Jmol-3D images |
Image 1 |
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InChI=1S/C5H9N3/c6-3-1-5-2-4-7-8-5/h2,4H,1,3,6H2,(H,7,8) Y
Key: JXDFEQONERDKSS-UHFFFAOYSA-N Y
InChI=1/C5H9N3/c6-3-1-5-2-4-7-8-5/h2,4H,1,3,6H2,(H,7,8)
Key: JXDFEQONERDKSS-UHFFFAOYAY
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Properties |
Molecular formula |
C5H9N3 |
Molar mass |
111.15 g mol−1 |
Pharmacology |
ATC code |
V04CG02
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DrugBank |
DB00272 |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) |
N (verify) (what is: Y/N?) |
Infobox references |
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Betazole is a histamine H2 receptor agonist. Also known as Ametazole. Betazole hydrochloride is known as gastramine and histalog.
It has been used as a gastric stimulant to test for maximal production of gastric secretion activity [1] The test can be used in diagnosis of diseases such as Zollinger-Ellison syndrome where there is excess acid production, in this case driven by over production of gastrin. The volume of acid secretion is measured following administration of betazole, diagnosis being secretion greater than 60% of the maximal acid secretion following betazole stimulation. This procedure can lead to complications and should be avoided in subjects with coronary artery disease [2] It is also used in diagnosis of gastritis in association with a test for secretin activity
Betazole is used as a stimulant in preference to histamine because of its specificity for the H2 receptor and its advantage of not generating the undesirable side effects that histamine would induce. It therefore does not require concomitant use of antihistaminic compounds to block the actions of histamine at other histamine receptor types.
Its action in stimulating histamine release can be of use when testing the effectiveness of H2 receptor blocking drugs such as Nizatidine.[3]
References
- ^ Wruble LD Cummins AJ Goldenberg J Schapiro H (1967). "The effect of intravenous histalog on gastric secretion in man". Digestive Diseases and Sciences 12 (11): 1087–1090. doi:10.1007/BF02233873. PMID 6057052.
- ^ Stoller JL Holubitsky IB Harrison RC Munro AI (1970). "Complications of the histalog test of gastric acid secretion". Digestive Diseases and Sciences 15 (7): 647–651. doi:10.1007/BF02236024. PMID 4951403.
- ^ Hammond JB, Offen WW (1988). "Effect of nizatidine and cimetidine on betazole-stimulated gastric secretion of normal subjects: comparison of effects on acid, water, and pepsin.". Am J Gastroenterol. 83 (1): 32–6. PMID 2892392.
Histaminergics
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Receptor |
H1
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- Agonists: 2-Pyridylethylamine
- Betahistine
- Histamine
- HTMT
- UR-AK49
Antagonists: 1st generation: 4-Methyldiphenhydramine
- Alimemazine
- Antazoline
- Azatadine
- Bamipine
- Benzatropine/Benztropine
- Bepotastine
- Bromazine
- Brompheniramine
- Buclizine
- Captodiame
- Carbinoxamine
- Chlorcyclizine
- Chloropyramine
- Chlorothen
- Chlorphenamine
- Chlorphenoxamine
- Cinnarizine
- Clemastine
- Clobenzepam
- Clocinizine
- Cyclizine
- Cyproheptadine
- Dacemazine
- Deptropine
- Dexbrompheniramine
- Dexchlorpheniramine
- Dimenhydrinate
- Dimetindene
- Diphenhydramine
- Diphenylpyraline
- Doxylamine
- Embramine
- Etodroxizine
- Etybenzatropine/Ethylbenztropine
- Etymemazine
- Flunarizine
- Histapyrrodine
- Homochlorcyclizine
- Hydroxyethylpromethazine
- Hydroxyzine
- Isopromethazine
- Isothipendyl
- Meclozine
- Mepyramine/Pyrilamine
- Mequitazine
- Methafurylene
- Methapyrilene
- Methdilazine
- Moxastine
- Niaprazine
- Orphenadrine
- Oxatomide
- Oxomemazine
- Phenindamine
- Pheniramine
- Phenyltoloxamine
- Pimethixene
- Piperoxan
- Pipoxizine
- Promethazine
- Propiomazine
- Pyrrobutamine
- Talastine
- Thenalidine
- Thenyldiamine
- Thiazinamium
- Thonzylamine
- Tolpropamine
- Tripelennamine
- Triprolidine
- 2nd generation: Acrivastine
- Alinastine
- Astemizole
- Azelastine
- Bamirastine
- Barmastine
- Bepiastine
- Bepotastine
- Bilastine
- Cabastinen
- Carebastine
- Cetirizine
- Clemastine
- Clemizole
- Clobenztropine
- Dorastine
- Ebastine
- Emedastine
- Epinastine
- Flezelastine
- Ketotifen
- Latrepirdine
- Levocabastine
- Linetastine
- Loratadine
- Mapinastine
- Mebhydrolin
- Mizolastine
- Moxastine
- Noberastine
- Octastine
- Olopatadine
- Perastine
- Piclopastine
- Rocastine
- Rupatadine
- Setastine
- Talastine
- Temelastine
- Terfenadine
- Zepastine
- 3rd generation: Desloratadine
- Fexofenadine
- Levocetirizine
- Ungrouped: Belarizine
- Efletirizine
- Elbanizine
- Flotrenizine
- Medrylamine
- Napactadine
- Pibaxizine
- Tagorizine
- Trelnarizine
- Trenizine
- Vapitadine
- Miscellaneous: Tricyclic antidepressants (amitriptyline,
- doxepin,
- trimipramine, etc)
- Tetracyclic antidepressants (mianserin,
- mirtazapine, etc)
- Typical antipsychotics (chlorpromazine,
- thioridazine, etc)
- Atypical antipsychotics (clozapine,
- olanzapine,
- quetiapine, etc)
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H2
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- Agonists: Amthamine
- Betazole
- Dimaprit
- Histamine
- HTMT
- Impromidine
- UR-AK49
Antagonists: Bisfentidine
- Burimamide
- Cimetidine
- Dalcotidine
- Donetidine
- Ebrotidine
- Etintidine
- Famotidine
- Lafutidine
- Lamtidine
- Lavoltidine/Loxtidine
- Lupitidine
- Metiamide
- Mifentidine
- Niperotidine
- Nizatidine
- Osutidine
- Oxmetidine
- Pibutidine
- Quisultazine/Quisultidine
- Ramixotidine
- Ranitidine
- Roxatidine
- Sufotidine
- Tiotidine
- Tuvatidine
- Venritidine
- Xaltidine
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H3
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- Agonists: α-Methylhistamine
- Cipralisant
- Histamine
- Imetit
- Immepip
- Immethridine
- Methimepip
- Proxyfan
Antagonists: A-349,821
- A-423,579
- ABT-239
- Betahistine
- Burimamide
- Ciproxifan
- Clobenpropit
- Conessine
- GSK-189,254
- Impentamine
- Iodophenpropit
- JNJ-5,207,852
- MK-0249
- NNC-38-1,049
- PF-03654746
- Pitolisant
- SCH-79,687
- Thioperamide
- VUF-5,681
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H4
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- Agonists: 4-Methylhistamine
- α-Methylhistamine
- Histamine
- VUF-8,430
Antagonists: JNJ-7,777,120
- Thioperamide
- VUF-6,002
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Transporter |
VMAT
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- Inhibitors: Ibogaine
- Reserpine
- Tetrabenazine
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Enzyme |
HDC
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- Inhibitors: Catechin
- Meciadanol
- Naringenin
- Tritoqualine
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HNMT
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- Inhibitors: Amodiaquine
- Diphenhydramine
- Harmaline
- Metoprine
- Quinacrine
- SKF-91,488
- Tacrine
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DAO
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- Inhibitors: Aminoguanidine
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Others |
Endogenous
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- Histamine; Precursors: L-Histidine; Cofactors: Vitamin B6
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Diagnostic agents (V04)
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Digestive system |
Diabetes
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Fat absorption
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Bile duct patency
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- Ceruletide
- Magnesium sulfate
- Sincalide
- Sorbitol
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Liver functional capacity
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- Galactose
- Sulfobromophthalein
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Gastric secretion
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- Betazole
- Caffeine and sodium benzoate
- Cation exchange resins
- Histamine phosphate
- Methylthioninium chloride
- Pentagastrin
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Exocrine pancreatic function
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- Bentiromide
- Pancreozymin
- Secretin
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Endocrine system |
Pituitary function
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Thyroid function
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Fertility disturbances
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Tuberculosis |
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Renal function |
- Alsactide
- Aminohippuric acid
- Indigo carmine
- Inulin and other polyfructosans
- Phenolsulfonphthalein
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UpToDate Contents
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English Journal
- Gastric secretory and hormonal patterns in end-stage chagasic achalasia.
- da Rocha JR, Ribeiro U, Cecconello I, Sallum RA, Takeda F, Nasi A, Szachnowicz S.SourceDigestive Surgery Division, Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil.
- Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E.Dis Esophagus.2009;22(7):606-10. doi: 10.1111/j.1442-2050.2009.00961.x. Epub 2009 Mar 17.
- Achalasia surgical treatment alters the esophagogastric junction anatomy (cardiomyotomy plus fundoplication or esophagectomy and gastric pull-up), thus favoring a certain degree of gastroesophageal reflux. Gastric secretory and hormonal functioning is not completely known in chagasic patients. The a
- PMID 19302218
- Gastric analysis with fractional test meals (ethanol, caffeine, and peptone meal), augmented histamine or pentagastrin tests, and gastric pH recording.
- Kwiecień S, Konturek SJ.SourceDepartment of Physiology, Jagiellonian University Medical College, Cracow, Poland.
- Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.J Physiol Pharmacol.2003 Dec;54 Suppl 3:69-82.
- For centuries it was recognized that the stomach produces a juice, which has acidic properties, however, it was not until 1824 when Prout demonstrated the presence of hydrochloric acid in gastric juice. At the same time experiments on a patient with gastric fistula began by W. Beaumont showing alter
- PMID 15075465
- Gastric tubes, meals, acid, and analysis: rise and decline.
- Rosenfeld L.SourceNew York University Medical Center, Department of Pathology, NY 10016, USA.
- Clinical chemistry.Clin Chem.1997 May;43(5):837-42.
- The stomach tube was first used to administer food and medication or to remove poisonous substances. Later, it served to aspirate the stomachs of patients with gastric retention. Chemical analysis of stomach contents after a meal was first suggested in 1871 and quickly became an important laboratory
- PMID 9166239
Japanese Journal
- 血清group 1 pepsinogen (PG1) と胃内外分泌動態との相関に関する臨床的研究
- 外因性エピネフリン投与の胃酸分泌機構に及ぼす影響に関する実験的検討
Related Links
- Betazole definition, a substance, C 5 H 9 N 3 , used in medicine to stimulate gastric secretion. See more. Thesaurus Translator Reference Word of the Day Blog Slideshows Apps by Dictionary My Account Log Out Log In Is it ...
- Betazole information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Betazole Description of Betazole Betazole: A histamine H2 agonist used clinically to test ...
Related Pictures
![Betazole structure.png](https://1mg.info/0/c/5/0930.jpg)
![105-20-4 皮他唑 betazole - CAS数据库](https://1mg.info/0/c/5/0931.jpg)
![Betazole - Wikipedia, the free](https://1mg.info/0/c/5/0932.jpg)
![File:Betazole.svg - Wikipedia, the free](https://1mg.info/0/c/5/0933.jpg)
![SERGE NOSSO MILIMI AZO BETAZOLE ZOLOZINA](https://1mg.info/0/c/5/0934.jpg)
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- 英
- betazole、betazole hydrochloride
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