βケトチオラーゼ
- 関
- acetyl-CoA acyltransferase、acetyl-CoA C-acyltransferase
WordNet
- to remain unmolested, undisturbed, or uninterrupted -- used only in infinitive form; "let her be"
- work in a specific place, with a specific subject, or in a specific function; "He is a herpetologist"; "She is our resident philosopher" (同)follow
- have life, be alive; "Our great leader is no more"; "My grandfather lived until the end of war" (同)live
- be identical to; be someone or something; "The president of the company is John Smith"; "This is my house"
- happen, occur, take place; "I lost my wallet; this was during the visit to my parents house"; "There were two hundred people at his funeral"; "There was a lot of noise in the kitchen"
- have the quality of being; (copula, used with an adjective or a predicate noun); "John is rich"; "This is not a good answer"
- occupy a certain position or area; be somewhere; "Where is my umbrella?" "The toolshed is in the back"; "What is behind this behavior?"
- spend or use time; "I may be an hour"
- stake on the outcome of an issue; "I bet $100 on that new horse"; "She played all her money on the dark horse" (同)wager, play
- the act of gambling; "he did it on a bet" (同)wager
- maintain with or as if with a bet; "I bet she will be there!" (同)wager
- second in order of importance; "the candidate, considered a beta male, was perceived to be unable to lead his party to victory"
- the 2nd letter of the Greek alphabet
- preliminary or testing stage of a software or hardware product; "a beta version"; "beta software"
- beets (同)genus Beta
PrepTutorEJDIC
- 《連結語として補語を伴なって…『である』,…だ,…です / 《位置・場所を表す語句を伴って》(…に)『ある』,いる(occupy a place or situation) / 〈物事が〉『存在する』,ある(exist);〈生物が〉生存する,生きている(live) / 行われる,起こる,発生する(take place, occur) / 存続する,そのままでいる(remain as before) / 《『be to』 do》 / …する予定である,…することになっている / …すべきだ / 《受動態の不定詞を伴って》…できる / 《命令》…するのだ / 《条件節に》…する意図がある / 《『if…were to』 do》…するとしたなら / 《『be』 do『ing』》《進行形》 / 《進行中の動作》…している,しつつある / 《近い未来》…しようとしている,するつもり / 《動作の反復》(いつも)…している / 《『be』+『他動詞の過去分詞』》《受動態》…される,されている / 《『be』+『自動詞の過去分詞』》《完了形》…した[状態にある]
- 『かけ』・(…との)かけ《+『with』+『名』》 / かけた物(金) / かけの対象 / 〈金・物〉'を'『かける』 / (かけ事・ゲームなどで)〈人〉‘と'『かけをする』《+『名』〈人〉+『on』+『名』》 / (…に)『かける』《+『on』(『against』)+『名』(one's do『ing』)》
- ベータ(ギリシア語アルファベットの第2文字;B,β;英語のB,b に遭当)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/02/19 00:59:57」(JST)
[Wiki en表示]
acetyl-CoA C-acyltransferase |
Identifiers |
EC number |
2.3.1.16 |
CAS number |
9029-97-4 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
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The final step of beta oxidation is the cleavage of 3-ketoacyl CoA by the thiol group of another molecule of Coenzyme A. This reaction is catalyzed by Acetyl-CoA C-acyltransferase (or Β-ketothiolase). The thiol is inserted between C-2 and C-3, which yields an acetyl CoA molecule and an acyl CoA molecule, which is two carbons shorter.
Acetyl-CoA C-acyltransferase belongs to the thiolase family of enzymes.
Examples
Human genes that encode acetyl-CoA C-acyltransferases include:
acetyl-CoA acyltransferase 1 (peroxisomal) |
Identifiers |
Symbol |
ACAA1 |
Entrez |
30 |
HUGO |
82 |
OMIM |
604054 |
RefSeq |
NM_001607 |
UniProt |
P09110 |
Other data |
EC number |
2.3.1.16 |
Locus |
Chr. 3 p23-p22 |
|
acetyl-CoA acyltransferase 2 (mitochondrial) |
Identifiers |
Symbol |
ACAA2 |
Entrez |
10449 |
HUGO |
83 |
OMIM |
604770 |
RefSeq |
NM_006111 |
UniProt |
P42765 |
Other data |
EC number |
2.3.1.16 |
Locus |
Chr. 18 q21 |
|
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit |
Identifiers |
Symbol |
HADHB |
Entrez |
3032 |
HUGO |
4803 |
OMIM |
143450 |
RefSeq |
NM_000183 |
UniProt |
P55084 |
Other data |
EC number |
2.3.1.16 |
Locus |
Chr. 2 p23 |
|
External links
- Acetyl-CoA+C-Acyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
Transferases: acyltransferases (EC 2.3)
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2.3.1: other than amino-acyl groups |
- acetyltransferases: Acetyl-Coenzyme A acetyltransferase
- N-Acetylglutamate synthase
- Choline acetyltransferase
- Dihydrolipoyl transacetylase
- Acetyl-CoA C-acyltransferase
- Beta-galactoside transacetylase
- Chloramphenicol acetyltransferase
- N-acetyltransferase
- Serotonin N-acetyl transferase
- HGSNAT
- ARD1A
- Histone acetyltransferase
- palmitoyltransferases: Carnitine O-palmitoyltransferase
- Serine C-palmitoyltransferase
- other: Acyltransferase like 2
- Aminolevulinic acid synthase
- Beta-ketoacyl-ACP synthase
- Glyceronephosphate O-acyltransferase
- Lecithin-cholesterol acyltransferase
- Glycerol-3-phosphate O-acyltransferase
- 1-acylglycerol-3-phosphate O-acyltransferase
- 2-acylglycerol-3-phosphate O-acyltransferase
- ABHD5
|
|
2.3.2: Aminoacyltransferases |
- Gamma-glutamyl transpeptidase
- Peptidyl transferase
- Transglutaminase
- Tissue transglutaminase
- Keratinocyte transglutaminase
- Factor XIII
|
|
2.3.3: converted into alkyl on transfer |
- Citrate synthase
- ATP citrate lyase
- HMG-CoA synthase
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|
- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 2.7.10
- 2.7.11-12
- 3.1
- 4.1
- 5.1
- 6.1-3
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Metabolism: lipid metabolism / fatty acid metabolism, triglyceride and fatty acid enzymes
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Synthesis |
Malonyl-CoA synthesis
|
- ATP citrate lyase
- Acetyl-CoA carboxylase
|
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Fatty acid synthesis/
Fatty acid synthase
|
- Beta-ketoacyl-ACP synthase
- Β-Ketoacyl ACP reductase
- 3-Hydroxyacyl ACP dehydrase
- Enoyl ACP reductase
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Fatty acid desaturases
|
- Stearoyl-CoA_desaturase-1
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Triacyl glycerol
|
- Glycerol-3-phosphate dehydrogenase
- Thiokinase
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Degradation |
Acyl transport
|
- Carnitine palmitoyltransferase I
- Carnitine-acylcarnitine translocase
- Carnitine palmitoyltransferase II
|
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Beta oxidation
|
General
|
- Acyl CoA dehydrogenase (ACADL
- ACADM
- ACADS
- ACADVL
- ACADSB)
- Enoyl-CoA hydratase
- Acetyl-CoA C-acyltransferase
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Unsaturated
|
- Enoyl CoA isomerase
- 2,4 Dienoyl-CoA reductase
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Odd chain
|
- Propionyl-CoA carboxylase
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Other
|
- Hydroxyacyl-Coenzyme A dehydrogenase
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To acetyl-CoA
|
- Malonyl-CoA decarboxylase
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Aldehydes
|
- Long-chain-aldehyde dehydrogenase
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
|
k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
|
m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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UpToDate Contents
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English Journal
- NMR-based urinalysis for beta-ketothiolase deficiency.
- Law CY1, Lam CW2, Ching CK3, Yau KC4, Ho TW4, Lai CK3, Mak CM3.
- Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2015 Jan 1;438:222-5. doi: 10.1016/j.cca.2014.08.041. Epub 2014 Sep 4.
- BACKGROUND: Beta-ketothiolase deficiency is a rare inborn errors of metabolism (IEM) affecting the catabolism of isoleucine, characterized by severe ketoacidosis in children of 6 to 24months old. A prompt diagnosis is of paramount importance as the metabolic decompensation can be effectively reverte
- PMID 25195009
- The use of an acetoacetyl-CoA synthase in place of a β-ketothiolase enhances poly-3-hydroxybutyrate production in sugarcane mesophyll cells.
- McQualter RB1, Petrasovits LA, Gebbie LK, Schweitzer D, Blackman DM, Chrysanthopoulos P, Hodson MP, Plan MR, Riches JD, Snell KD, Brumbley SM, Nielsen LK.
- Plant biotechnology journal.Plant Biotechnol J.2014 Dec 23. doi: 10.1111/pbi.12298. [Epub ahead of print]
- Engineering the production of polyhydroxyalkanoates (PHAs) into high biomass bioenergy crops has the potential to provide a sustainable supply of bioplastics and energy from a single plant feedstock. One of the major challenges in engineering C4 plants for the production of poly[(R)-3-hydroxybutyrat
- PMID 25532451
- Characterization of p-Hydroxycinnamate Catabolism in a Soil Actinobacterium.
- Otani H1, Lee YE1, Casabon I1, Eltis LD2.
- Journal of bacteriology.J Bacteriol.2014 Dec 15;196(24):4293-303. doi: 10.1128/JB.02247-14. Epub 2014 Sep 29.
- p-Hydroxycinnamates, such as ferulate and p-coumarate, are components of plant cell walls and have a number of commercial applications. Rhodococcus jostii RHA1 (RHA1) catabolizes ferulate via vanillate and the β-ketoadipate pathway. Here, we used transcriptomics to identify genes in RHA1 that are u
- PMID 25266382
Japanese Journal
- 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency : impaired catabolism of isoleucine presenting as neurodegenerative disease
- SASS Jorn Oliver,FORSTNER Rosemarie,SPERL Wolfgang
- Brain & development 26(1), 12-14, 2004-01-01
- NAID 10013565726
- The clinical phenotype and outcome of mitochondrial acetoacetyl-CoA thiolase deficiency (beta-ketothiolase or T2 deficiency) in 26 enzymatically proved and mutation-defined patients
- Fine structural analysis of the Zoogloea ramigera phbA-phbB locus encoding beta-ketothiolase and acetoacetyl-CoA reductase: nucleotide sequence of phbB
Related Links
- The signs and symptoms of beta-ketothiolase deficiency include vomiting, dehydration, trouble breathing, extreme tiredness, and occasionally convulsions. These episodes are called ketoacidotic attacks and can sometimes lead to coma.
- Beta-ketothiolase deficiency is an inherited disorder in which the body cannot effectively process a protein building block (amino acid) called isoleucine. This disorder also impairs the body's ability to process ketones, which are molecules ...
Related Pictures
★リンクテーブル★
[★]
アセチルCoAアシルトランスフェラーゼ、アセチルCoAアシル基転移酵素、アセチルCoAアシル転移酵素
- 関
- acetyl-CoA C-acyltransferase、beta-ketothiolase
[★]
- 英
- beta-ketothiolase
- 関
- アセチルCoA C-アシルトランスフェラーゼ、アセチルCoAアシルトランスフェラーゼ、β-ケトチオラーゼ
[★]
- 英
- beta-ketothiolase
- 関
- βケトチオラーゼ
[★]
β、ベータ
[★]