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1. 癌に対する補完代替療法 complementary and alternative therapies for cancer
2. アレルギー疾患の治療のための漢方薬 chinese herbal medicine for the treatment of allergic diseases
3. バーター症候群およびギテルマン症候群 bartter and gitelman syndromes
4. 代謝性アルカローシスの臨床症状および評価 clinical manifestations and evaluation of metabolic alkalosis
5. 嚢胞性線維症：臨床症状および診断 cystic fibrosis clinical manifestations and diagnosis

Role of 13-(di)phenylalkyl berberine derivatives in the modulation of the activity of human topoisomerase IB.

Vieira S1, Castelli S1, Falconi M1, Takarada J1, Fiorillo G2, Buzzetti F2, Lombardi P2, Desideri A3.
International journal of biological macromolecules.Int J Biol Macromol.2015 Jun;77:68-75. doi: 10.1016/j.ijbiomac.2015.02.051. Epub 2015 Mar 14.
Topoisomerases IB are anticancer and antimicrobial targets whose inhibition by several natural and non-natural compounds has been documented. The inhibition effect by berberine and some 13-(di)phenylalkyl berberine derivatives has been tested towards human topoisomerase IB. Derivatives belonging to
PMID 25783020

In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis.

Zhou Y1, Liu SQ2, Peng H1, Yu L1, He B1, Zhao Q1.
International immunopharmacology.Int Immunopharmacol.2015 May 19. pii: S1567-5769(15)00236-2. doi: 10.1016/j.intimp.2015.05.014. [Epub ahead of print]
Berberine chloride (BBR) is an isoquinoline alkaloid that possesses promising protective efficacies against osteoarthritis (OA). Nevertheless, the therapeutic agent of this substance in OA is limited by its poor aqueous solubility, low bioavailability and short biological half-life. In this study, c
PMID 26002585

Analysis of the antioxidative function of the radioprotective Japanese traditional (Kampo) medicine, hangeshashinto, in an aqueous phase.

Matsumoto C1, Sekine-Suzuki E2, Nyui M3, Ueno M3, Nakanishi I3, Omiya Y4, Fukutake M1, Kase Y4, Matsumoto KI5.
Journal of radiation research.J Radiat Res.2015 Apr 16. pii: rrv023. [Epub ahead of print]
Oral mucositis (OM) is a common and painful complication of radiotherapy for head and neck cancer. Hangeshashinto (HST), a Japanese traditional medicine, is known to alleviate radiotherapy- and/or chemotherapy-induced OM; however, the detailed mechanism has not yet been clarified. The aim of the pre
PMID 25883171

Coptis Rhizome and Phellodendron Bark Extracts and Berberine Inhibit the Development of Mouse Embryos

TSUNODA Yukio,KATO Yoko
Journal of mammalian ova research 28(1), 40-46, 2011-04
… We examined the effects of both extracts and of berberine, a major component of these plants, on in vitro development of zygotes and on fullterm fetal development in the mouse. … Mouse zygotes were cultured in medium containing water-soluble extracts of Coptis rhizome or Phellodendron bark, or berberine at various concentrations for 5 days and the potential of zygotes to develop to blastocysts was examined. …
NAID 120004623377

福田直通,米光美知子
分析化学 54(1), 79-82, 2005-01-05
… Berberine and palmatine are isoquinoline alkaloids contained in "oubaku", Phellodendri Cortex, and their structures are similar. … a small quantity of palmatine chloride exists even in a commercial berberine chloride. … These phenomena suggest that a possibility exist to purify berberine chloride only by recrystallization. …
NAID 110002910025

Inhibition of the Bacterial Surface Protein Anchoring Transpeptidase Sortase by Isoquinoline Alkaloids

Kim Soo-Hwan,Shin Dong-Sun,Oh Mi-Na [他],CHUNG Soon-Chun,LEE Jang-Suk,OH Ki-Bong
Bioscience, biotechnology, and biochemistry 68(2), 421-424, 2004-02-23
… extract was characterized as the isoquinoline alkaloid, berberine chloride, by spectral analysis. … Among the four isoquinoline alkaloids tested, berberine chloride had strong inhibitory activity. … These results indicate that berberine is a possible candidate for the development of a bacterial sortase inhibitor. …
NAID 10013142155