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1. 閉経期のホルモン療法で用いる製剤 preparations for menopausal hormone therapy
2. 更年期のほてり menopausal hot flashes
3. 骨粗鬆症の予防 prevention of osteoporosis
4. ホルモン療法を用いた閉経期症状の治療 treatment of menopausal symptoms with hormone therapy
5. 骨粗鬆症の予防および治療のための選択的エストロゲン受容体調節剤 selective estrogen receptor modulators for prevention and treatment of osteoporosis

Selective estrogen receptor modulators in T cell development and T cell dependent inflammation.

Bernardi AI1, Andersson A2, Stubelius A3, Grahnemo L4, Carlsten H5, Islander U6.
Immunobiology.Immunobiology.2015 Oct;220(10):1122-8. doi: 10.1016/j.imbio.2015.05.009. Epub 2015 May 11.
Lasofoxifene (las) and bazedoxifene (bza) are third generation selective estrogen receptor modulators (SERMs) with minimal estrogenic side effects, approved for treatment of postmenopausal osteoporosis. T cells are involved in the pathology of postmenopausal osteoporosis and previous studies have es
PMID 26044996

Selective estrogen receptor modulators and the combination therapy conjugated estrogens/bazedoxifene: A review of effects on the breast.

Pickar JH1, Komm BS2.
Post reproductive health.Post Reprod Health.2015 Aug 19. pii: 2053369115599090. [Epub ahead of print]
Traditional menopausal hormone therapy containing estrogens/progestin has been associated with an increased risk of breast cancer, and estrogen exposure is known to promote growth and proliferation of a majority of breast cancers. Therefore, it is important for clinicians to consider the breast safe
PMID 26289836

The effects of bazedoxifene on bone structural strength evaluated by hip structure analysis.

Beck TJ1, Fuerst T2, Gaither KW2, Sutradhar S3, Levine AB4, Hines T4, Yu CR5, Williams R6, Mirkin S4, Chines AA4.
Bone.Bone.2015 Aug;77:115-9. doi: 10.1016/j.bone.2015.04.027. Epub 2015 Apr 23.
Bazedoxifene (BZA) is a selective estrogen receptor modulator that has been shown to prevent and treat postmenopausal osteoporosis. Hip structure analysis (HSA) can be used to extract bone structural properties related to strength from hip bone mineral density (BMD) scans. This exploratory analysis
PMID 25917574