WordNet

staining readily with basic dyes
a leukocyte with basophilic granules easily stained by basic stains (同)basophile
an immature leukocyte normally found in bone marrow

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/11 04:23:22」(JST)

wiki en

Basophilic^[1]

Eosinophilic^[2]

Neutrophilic^[3]

A myelocyte is a young cell of the granulocytic series, occurring normally in bone marrow (can be found in circulating blood when caused by certain diseases).

Histology

When stained with the usual dyes, the cytoplasm is distinctly basophilic and relatively more abundant than in myeloblasts or promyelocytes, even though myelocytes are smaller cells.

Numerous cytoplasmic granules are present in the more mature forms of myelocytes. Neutrophilic and eosinophilic granules are peroxidase-positive, while basophilic granules are not.

The nuclear chromatin is coarser than that observed in myelocyte, but it is relatively faintly stained and lacks a well defined membrane.

The nucleus is fairly regular in contour (not indented), and seems to be 'buried' beneath the numerous cytoplasmic granules. (If the nucleus were indented, it would likely be a metamyelocyte.)

Maturation

Myelocytes are derived from promyelocytes and give rise to metamyelocytes.

Measurement

There is an internationally agreed method of counting blasts, with results from M1 upwards.

Additional images

Hematopoiesis

References

^ Histology image:01809loa from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide. Oxford University Press. ISBN 978-0195151732.
^ Histology image:01810loa from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide. Oxford University Press. ISBN 978-0195151732.
^ Histology image:01804loa from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide. Oxford University Press. ISBN 978-0195151732.

External links

Neutrophilic Myelocyte Presented by the University of Virginia
Eosinophilic Myelocyte Presented by the University of Virginia
Basophilic Myelocyte Presented by the University of Virginia
Image at queensu.ca

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 末梢血塗抹標本の評価 evaluation of the peripheral blood smear
2. 急性骨髄性白血病の分類 classification of acute myeloid leukemia
3. 骨髄造血の制御 regulation of myelopoiesis
4. 好中球増多症の患者へのアプローチ approach to the patient with neutrophilia
5. 慢性骨髄性白血病の臨床症状および診断 clinical manifestations and diagnosis of chronic myeloid leukemia

English Journal

E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3K/Akt pathway.

Yingchun L, Xiujuan Q, Jinglei Q, Ye Z, Jing L, Yuee T, Xuejun H, Kezuo H, Yunpeng L.SourceDepartment of Medical Oncology, China Medical University.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.].Braz J Med Biol Res.2011 Feb;44(2):105-11. Epub 2010 Dec 17.
Arsenic trioxide (ATO) is a strong inducer of apoptosis in malignant hematological cells. Inducible phosphatidyl inositol 3 kinase (PI3K)-Akt activation promotes resistance to ATO. In the present study, we evaluated whether E3 ubiquitin ligase Cbl-b, a negative regulator of PI3K activation, is invol
PMID 21180886

Eosinophil progenitors in airway diseases: clinical implications.

Denburg JA, Keith PK.SourceDivision of Clinical Immunology and Allergy, McMaster University, Hamilton, ON, Canada. denburg@mcmaster.ca
Chest.Chest.2008 Nov;134(5):1037-43. doi: 10.1378/chest.08-0485.
Asthma, allergic rhinitis, nasal polyposis, chronic rhinosinusitis, and related forms of upper and lower airway diseases are often characterized by eosinophilic and basophilic inflammation, involving systemic processes. Eosinophil/basophil (Eo/B) lineage-committed progenitor cells in cord blood, per
PMID 18988778

Japanese Journal

Granulopoiesis in the head-kidney of the sea bass (Dicentrarchus labrax L.9: An ultrastructural study.

MESEGUER J.,ESTEBAN M. A.,AYALA A. GARCIA,RUIZ A. LOPEZ,AGULLEIRO B.
Ａｒｃｈｉｖｅｓ　ｏｆ　Ｈｉｓｔｏｌｏｇｙ　ａｎｄ　Ｃｙｔｏｌｏｇｙ 53(3), 287-296, 1990
… The heterophilic, acidophilic and basophilic series consisting of promyelocyte, myelocyte, metamyelocyte and mature granulocyte stages are described. … The scarce cells of the basophilic series showed similar characteristics to those described in other fish species. …
NAID 130003561870

骨髄組織培養に於ける墨粒貪喰能の研究第二編健康人及び家兎骨髄内細胞の墨粒貪喰能に就て

角南宏
岡山医学会雑誌 68(8), 1179-1189, 1956-08-31
… The results are as follow: 1) The majority of neutrophilic leukocytes such as myeloblast and promyelocyte but a few exceptions of myelocyte exhibited no phagocytosis. … 2) Usually no phagocytic behaviors were recognized in eosinophilie, basophilic-leukocytes, lymphocytes or erythroblasts. …
NAID 120002426716

Related Pictures

Myeloid Cell Peripheral blood smear: numerous blasts, few basophils, a basophilic | Download HLS [ Bone Marrow and Hemopoiesis, bone marrow smear, basophilic myelocyte] HIGH MAG Hematopoiesis Basophilic Myelocyte - 2 | ERA Basophilic myelocyte in bone marrow smear (human) - POJA Collection Microscopic Anatomy