WordNet

with the wind abaft the beam; "a ship sailing large"
a garment size for a large person
above average in size or number or quantity or magnitude or extent; "a large city"; "set out for the big city"; "a large sum"; "a big (or large) barn"; "a large family"; "big businesses"; "a big expenditure"; "a large number of newspapers"; "a big group of scientists"; "large areas of the world" (同)big
at a distance, wide of something (as of a mark)
fairly large or important in effect; influential; "played a large role in the negotiations"
having broad power and range and scope; "taking the large view"; "a large effect"; "a large sympathy"
an organelle in the cytoplasm of a living cell; they attach to mRNA and move down it one codon at a time and then stop until tRNA brings the required amino acid; when it reaches a stop codon it falls apart and releases the completed protein molecule for u
(microbiology) single-celled or noncellular spherical or spiral or rod-shaped organisms lacking chlorophyll that reproduce by fission; important as pathogens and for biochemical properties; taxonomy is difficult; often considered to be plants (同)bacterium
relating to or caused by bacteria; "bacterial infection"

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Liu Q1, Fredrick K2.
Journal of molecular biology.J Mol Biol.2016 Feb 12. pii: S0022-2836(16)00114-5. doi: 10.1016/j.jmb.2016.02.009. [Epub ahead of print]
The ribosome is a large two-subunit ribonucleoprotein machine that translates the genetic code in all cells, synthesizing proteins according to the sequence of the mRNA template. During translation, the primary substrates, transfer RNAs (tRNAs), pass through binding sites formed between the two subu
PMID 26880335

Ling C1, Ermolenko DN2.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2015 Dec 29;112(52):15874-9. doi: 10.1073/pnas.1520337112. Epub 2015 Dec 14.
Intersubunit rotation and movement of the L1 stalk, a mobile domain of the large ribosomal subunit, have been shown to accompany the elongation cycle of translation. The initiation phase of protein synthesis is crucial for translational control of gene expression; however, in contrast to elongation,
PMID 26668356

Short Proline-Rich Antimicrobial Peptides Inhibit Either the Bacterial 70S Ribosome or the Assembly of its Large 50S Subunit.

Krizsan A1, Prahl C1, Goldbach T1, Knappe D1, Hoffmann R2.
Chembiochem : a European journal of chemical biology.Chembiochem.2015 Nov 2;16(16):2304-8. doi: 10.1002/cbic.201500375. Epub 2015 Oct 8.
Short proline-rich antimicrobial peptides (PrAMPs) are a promising class of antibiotics that use novel mechanisms, thus offering the potential to overcome the health threat of multiresistant pathogens. The peptides bind to the bacterial 70S ribosome and can inhibit protein translation. We report tha
PMID 26448548

Proteomic characterization of the small subunit of Chlamydomonas reinhardtii chloroplast ribosome : identification of a novel S1 domain-containing protein and unusually large orthologs of bacterial S2, S3, and S5

小原康治
日本化学療法学会雑誌 48(3), 169-190, 2000
臨床分離株におけるマクロライド抗生物質耐性に関して, 30年前には, 単純に (1) 70Sリボソームの50Sサブユニット中の23Sr RNAの特定アデニンがN<SUP>6</SUP>, N<SUP>6</SUP>-ジメチル化酵素によって修飾されるために, マクロライド抗生物質が結合できなくなって耐性化するとだけ覚えておけば十分であった。しかし, 現 …
NAID 130004102587