アゼルニジピン
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/21 02:49:37」(JST)
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Azelnidipine
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Systematic (IUPAC) name |
3-1-Benzhydryl-3-azetidinyl 5-isopropyl 2-amino-6-methyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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Clinical data |
Trade names |
CalBlock |
AHFS/Drugs.com |
International Drug Names |
Legal status |
|
Routes of
administration |
Oral |
Identifiers |
CAS Registry Number |
123524-52-7 N |
ATC code |
None |
PubChem |
CID: 65948 |
UNII |
PV23P19YUG Y |
KEGG |
D01145 Y |
ChEMBL |
CHEMBL1275868 N |
Chemical data |
Formula |
C33H34N4O6 |
Molecular mass |
582.64 g/mol |
SMILES
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[O-][N+](=O)c1cccc(c1)C5C(/C(=O)OC(C)C)=C(\NC(\N)=C5\C(=O)OC4CN(C(c2ccccc2)c3ccccc3)C4)C
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InChI
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InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3 Y
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Key:ZKFQEACEUNWPMT-UHFFFAOYSA-N Y
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N (what is this?) (verify) |
Azelnidipine (INN; marketed under the brand name CalBlock — カルブロック) is a dihydropyridine calcium channel blocker. It is sold in Japan by Daiichi-Sankyo pharmaceuticals, Inc. Unlike nicardipine, it has a gradual onset and has a long-lasting hypotensive effect, with little increase in heart rate.[1]
References
- ^ Oizumi K, Nishino H, Koike H, Sada T, Miyamoto M, Kimura T (September 1989). "Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker". Jpn. J. Pharmacol. 51 (1): 57–64. doi:10.1254/jjp.51.57. PMID 2810942. Scholar search[dead link]
English Journal
- Combined Effect of Angiotensin II Receptor Blocker and Either a Calcium Channel Blocker or Diuretic on Day-by-Day Variability of Home Blood Pressure: The Japan Combined Treatment With Olmesartan and a Calcium-Channel Blocker Versus Olmesartan and Diuretics Randomized Efficacy Study.
- Matsui Y, O'Rourke MF, Hoshide S, Ishikawa J, Shimada K, Kario K.SourceDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan; University of New South Wales/St Vincent's Clinic, Sydney, New South Wales, Australia.
- Hypertension.Hypertension.2012 Apr 30. [Epub ahead of print]
- Day-by-day home blood pressure (BP) variability (BPV) was reported to be associated with increased cardiovascular risk. We aimed to test the hypothesis that the angiotensin II receptor blocker/calcium-channel blocker combination decreases day-by-day BPV more than the angiotensin II receptor blocker/
- PMID 22547439
- Long-Term Effects of Calcium Antagonists on Augmentation Index in Hypertensive Patients with Chronic Kidney Disease: A Randomized Controlled Study.
- Takenaka T, Seto T, Okayama M, Kojima E, Nodaira Y, Sueyoshi K, Kikuta T, Watanabe Y, Inoue T, Takane H, Ohno Y, Suzuki H.SourceDepartment of Nephrology, Saitama Medical University, Faculty of Medicine, Moroyama, Japan.
- American journal of nephrology.Am J Nephrol.2012 Apr 20;35(5):416-423. [Epub ahead of print]
- Background: Our previous retrospective study showed that benidipine was superior to amlodipine (AM) for reducing proteinuria and preserving the augmentation index (AI) in patients with chronic kidney disease (CKD). Methods: The present study enrolled CKD patients whose blood pressure was not well co
- PMID 22517217
Japanese Journal
- Anti-hypertensive azelnidipine preserves insulin signaling and glucose uptake against oxidative stress in 3T3-L1 adipocytes
- Tatsumi Fuminori,Kaneto Hideaki,Hashiramoto Mitsuru,Tawaramoto Kazuhito,Obata Atsushi,Kimura Tomohiko,Shimoda Masashi,Hamamoto Sumiko,Kanda-Kimura Yukiko,Kamei Shinji,Mune Tomoatsu,Matsuda Masafumi,Kaku Kohei
- Endocrine Journal advpub(0), 2015
- … In this study, we evaluated the effects of azelnidipine, a calcium channel blocker, on ROS-mediated insulin resistance in adipocytes. … When 3T3-L1 adipocytes were exposed to ROS, insulin-mediated glucose uptake was suppressed, but such phenomena were not observed in the presence of azelnidipine. … Phosphorylation of insulin receptor and phosphorylation of Akt were suppressed by ROS, which was mitigated by azelnidipine treatment. …
- NAID 130005075494
- Ca拮抗薬Azelnidipineが高血圧患者の尿酸代謝に及ぼす効果ー第2報ー
- 宮崎 聡,平田 成正,山本 康孝,野坂 美仁,井川 修,吉田 明雄,水田 栄之助,太田原 顕,桑原 政成,浜田 俊弘,荻野 和秀,加藤 雅彦,山本 一博,久留 一郎
- 痛風と核酸代謝 38(1), 59-60, 2014
- NAID 130004680228
- Beneficial Effect of Combination Therapy by Losartan and Azelnidipine on Albuminuria and Renal Function in Type 2 Diabetic Patients With Chronic Kidney Disease
- 長見 晴彦,田邊 一明,竹下 治男
- Shimane journal of medical science 30(1), 11-21, 2013-11-01
- … To those 46 patients, losartan which is one of angiotensin receptor blockers(ARBs)and azelnidipine which is one of calcium channel blockers(CCBs)were administered in order to examine whether combined administration of losartan and azelnidipine(Los/Azl treatment)provides superior reduction in proteinuria compared to nifedipine or amlodipine in hypertensive type 2 diabetes patients with CKD. …
- NAID 120005587548
Related Links
- Azelnidipineとは?goo Wikipedia (ウィキペディア) 。出典:Wikipedia(ウィキペディア)フリー百科事典。 Azelnidipineとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへスキップ ...
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Related Pictures
★リンクテーブル★
[★]
- 英
- azelnidipine
- 商
- カルブロック Calblock、レザルタス配合
- 関
- 血圧降下剤