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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/06 22:03:49」(JST)

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Azelnidipine (INN; marketed under the brand name Calblock) is a dihydropyridine calcium channel blocker. It is sold in Japan by Daiichi-Sankyo pharmaceuticals, Inc. Unlike nicardipine, it has a gradual onset and has a long-lasting hypotensive effect, with little increase in heart rate.^[1]

References[edit]

^ Oizumi K, Nishino H, Koike H, Sada T, Miyamoto M, Kimura T (September 1989). "Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker" (^{[dead link]} – ^{Scholar search}). Jpn. J. Pharmacol. 51 (1): 57–64. doi:10.1254/jjp.51.57. PMID 2810942.

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English Journal

Clinical study with azelnidipine in patients with essential hypertension. Antiarteriosclerotic and cardiac hypertrophy-inhibitory effects and influence on autonomic nervous activity.

Nada T1, Nomura M, Koshiba K, Kawano T, Mikawa J, Ito S.
Arzneimittel-Forschung.Arzneimittelforschung.2007;57(11):698-704. doi: 10.1055/s-0031-1296670.
A dihydropyridine calcium (Ca) antagonist, azelnidipine (CAS 123524-52-7, Calblock), exhibits hypotensive effects for a prolonged duration, and has been reported to have a strong antiarteriosclerotic action due to its high affinity for vascular tissues and antioxidative action. It has also been repo
PMID 18193691

Simultaneous determination of azelnidipine and two metabolites in human plasma using liquid chromatography-tandem mass spectrometry.

Kawabata K1, Urasaki Y.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2006 Nov 21;844(1):45-52. Epub 2006 Jul 18.
A quantitative assay method by liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) for the simultaneous determination of azelnidipine and its two metabolites, M-1 (aromatized form) and M-2 (hydroxylated form), in human plasma was developed and validated. Plasma samp
PMID 16854634

Pharmacological profiles and clinical effects of azelnidipine, a long-acting calcium channel blocker.

Sada T1, Saito H.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.Nihon Yakurigaku Zasshi.2003 Dec;122(6):539-47.
Azelnidipine (Calblock) is a newly developed dihydropyridine-type calcium antagonist for the treatment of hypertension. In hypertensive animals, a single oral administration of azelnidipine caused a slowly developed and long-lasting hypotensive effect with a little reflex tachycardia. The extent of
PMID 14639008

Japanese Journal

Effect of a Single Glass of Grapefruit Juice on the Apparent Oral Bioavailability of the Dihydropyridine Calcium Channel Antagonist, Azelnidipine, in Healthy Japanese Volunteers

臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 37(3), 127-133, 2006-05-31
NAID 10019168973

持続型カルシウム拮抗薬アゼルニジピン(カルブロック^【○!R】)の薬理特性と臨床効果

日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA 122(6), 539-547, 2003-12-01
NAID 10013680035

Related Pictures

CALBLOCK $CALBLOCK \ CALBLOCK The mouth of a water$ calcaire magnétique CALBLOCK - 090609 calblock antihypertensive agent calblock Washing Machine Calblock Water Softener $CALBLOCK \ CALBLOCK Уст-во для$ calblock kirec filtresi calblock kirec calblock fitru anticalcar magnetic pentru

★リンクテーブル★

リンク元

「アゼルニジピン」

Azelnidipine
Systematic (IUPAC) name
	O3-[1-[di(phenyl)methyl]azetidin-3-yl] O5-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	123524-52-7
ATC code	None
PubChem	CID 65948
ChemSpider	59352
UNII	PV23P19YUG
KEGG	D01145
Chemical data
Formula	C33H34N4O6
Mol. mass	582.64 g/mol
	SMILES [O-][N+](=O)c1cccc(c1)C5C(/C(=O)OC(C)C)=C(\NC(\N)=C5\C(=O)OC4CN(C(c2ccccc2)c3ccccc3)C4)C;
	InChI InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3 ; Key:ZKFQEACEUNWPMT-UHFFFAOYSA-N ;
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　　[★]

英: azelnidipine
商: カルブロック Calblock、レザルタス配合
関: 血圧降下剤

[pmid2810942-1] Oizumi K, Nishino H, Koike H, Sada T, Miyamoto M, Kimura T (September 1989). "Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker" (^{[dead link]} – ^{Scholar search}). Jpn. J. Pharmacol. 51 (1): 57–64. doi:10.1254/jjp.51.57. PMID 2810942.

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案内

案内

Calblock