| Autotransplantation |
| Intervention |
| MeSH |
D014182 |
Autotransplantation is the transplantation of organs, tissues, or even particular proteins from one part of the body to another in the same person (auto- = "self-"). The autologous tissue (also called autogenous, autogeneic, or autogenic tissue) transplanted by such a procedure is called an autograft or autotransplant. It is contrasted with allotransplantation (from other individual of same species) and xenotransplantation (from other species). A common example is the removal of a piece of bone (usually from the hip) and its being ground into a paste for the reconstruction of another portion of bone.
Contents
- 1 Autologous blood donation
- 2 Bone autograft
- 3 Skin autograft
- 4 Autologous organ graft
- 5 See also
- 6 External links
- 7 References
Autologous blood donation
See also: Intraoperative blood salvage
In blood banking terminology, autologous blood donation refers to a blood donation marked for use by the donor, typically for a scheduled surgery. (Generally, the notion of "donation" does not refer to giving to one's self, though in this context it has become somewhat acceptably idiomatic.) They are commonly called "Autos" by blood bank personnel, and it is one major form of the more general concept of autotransfusion (the other being intraoperative blood salvage).
Some advantages of autologous blood donation are:
- Blood type will always match, even with a rare blood type or antibody type.
- If only autologous blood is used during surgery the risk of exposure to infectious disease such as hepatitis or HIV from blood is eliminated.
- The risk of allergic reactions is reduced.
The disadvantages are:
- Higher cost due to individualized processing, record-keeping, and management.
- In most cases, the blood is discarded if it is not used instead of being added to the general supply.
- Blood donation prior to colorectal cancer surgery seemed causative for a worse overall and colorectal cancer specific survival.[1]
Autologous blood is not routinely tested for infectious diseases markers such as HIV antibodies. In the United States, autologous blood is tested only if it is collected in one place and shipped to another.
There is also a risk that, in an emergency or if more blood is required than has been set aside in advance, the patient could still be exposed to donor blood instead of autologous blood. Autologous donation is also not suitable for patients who are medically unable to or advised not to give blood, such as cardiac patients or small children and infants.
Bone autograft
See also: Bone grafting § Autologous bone grafting
Illustration depicting bone autograft.
In orthopaedic medicine, bone graft can be sourced from a patient's own bone in order to fill space and produce an osteogenic response in a bone defect. However, due to the donor-site morbidity associated with autograft, other methods such as bone allograft and bone morphogenetic proteins and synthetic graft materials are often used as alternatives. Autografts have long been considered the "Gold Standard" in Oral Surgery and Implant Dentistry because it offered the best regenerations results. Lately, the introduction of morphogen-enhanced bone graft substitutes have shown to show similar success rates and quality of regeneration; however, their price is still very high.
Skin autograft
Skin autografting is commonly used to treat burns victims.
Autologous organ graft
Recent advances in decellularization have allowed researchers to recreate an organ using a patient's own tissue cells that are grafted on an allograft protein scaffold.[2]
See also
- Autotransfusion - the process of returning to a patient their own blood that has been lost.
- Replantation - reattaching a severed limb or other part of the body.
- Rotationplasty - attaching the foot with ankle joint (reversed) to the femur to replace the knee.
External links
References
- ^ Harlaar, JJ; Gosselink, MP; Hop, WC; Lange, JF; Busch, OR; Jeekel, H (November 2012). "Blood transfusions and prognosis in colorectal cancer: long-term results of a randomized controlled trial.". Annals of surgery 256 (5): 681–7. doi:10.1097/SLA.0b013e318271cedf. PMID 23095610.
- ^ http://video.nationalgeographic.com/video/national-geographic-channel/full-episodes/explorer/ngc-how-to-build-a-beating-heart/
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Organ transplantation
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| Types |
- Allotransplantation
- Autotransplantation
- Xenotransplantation
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| Organs and tissues |
- Bone
- Bone marrow
- Brain
- Corneal
- Face
- Hand
- Head
- Heart
- Heart–lung
- Intestine
- Kidney
- Liver
- Lung
- Pancreas
- Penis
- Skin
- Spleen
- Thymus
- Uterus
- Vagina
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| Medical grafting |
- Bone grafting
- Skin grafting
- Vascular grafting
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| Organ donation |
- Non-heart-beating donation
- Organ harvesting
- Organ trade
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| Complications |
- Graft-versus-host disease
- Post-transplant lymphoproliferative disorder
- Transplant rejection
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| Organizations |
- Anthony Nolan
- Eurotransplant
- Halachic Organ Donor Society
- Human Tissue Authority
- National Marrow Donor Program
- National Transplant Organization
- NHS Blood and Transplant
- United Network for Organ Sharing
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| Countries |
- Organ transplantation in different countries
- Organ transplantation in China
- Organ transplantation in Israel
- Organ transplantation in Japan
- Organ theft in Kosovo
- Gurgaon kidney scandal
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| People |
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Heart
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- Christiaan Barnard
- Adrian Kantrowitz
- Richard Lower
- Norman Shumway
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Kidney
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- J. Hartwell Harrison
- John P. Merrill
- Joseph Murray
- Michael Woodruff
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Liver
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Lung
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- Joel D. Cooper
- Vladimir Demikhov
- James Hardy
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Other
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- Alexis Carrel
- Jean-Michel Dubernard
- Donna Mansell
- Bruce Reitz
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- List of organ transplant donors and recipients
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| Related topics |
- Biomedical tissue
- Edmonton protocol
- Eye bank
- Immunosuppressive drugs
- Lung allocation score
- Machine perfusion
- Total body irradiation
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Transfusion medicine
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| General concepts |
- Apheresis (plasmapheresis, plateletpheresis, leukapheresis)
- Blood transfusion
- Coombs test (direct and indirect)
- Cross-matching
- Exchange transfusion
- International Society of Blood Transfusion
- Intraoperative blood salvage
- ISBT 128
- Transfusion reactions
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Blood group systems /
blood types |
- ABO
- Chido-Rodgers
- Colton
- Cromer
- Diego
- Dombrock
- Duffy
- Er
- FORS
- Gerbich
- GIL
- GLOB
- Hh
- Ii
- Indian
- JR
- JMH
- Kell (Xk)
- Kidd
- Knops
- Lan
- Lewis
- Lutheran
- LW
- MNS
- OK
- P
- Raph
- Rh and RHAG
- Scianna
- T-Tn
- Vel
- Xg
- Yt
- Other
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Blood products /
blood donation |
- Whole blood
- Platelets
- Red blood cells
- Plasma / Fresh frozen plasma / PF24 (Cryoprecipitate + Cryosupernatant)
- Blood substitutes
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Index of cells from bone marrow
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| Description |
- Immune system
- Cells
- Physiology
- coagulation
- proteins
- granule contents
- colony-stimulating
- heme and porphyrin
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| Disease |
- Red blood cell
- Monocyte and granulocyte
- Neoplasms and cancer
- Histiocytosis
- Symptoms and signs
- Blood tests
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| Treatment |
- Transfusion
- Drugs
- thrombosis
- bleeding
- other
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