自律神経失調症、自律神経失調
- 関
- autonomic imbalance
WordNet
- relating to or controlled by the autonomic nervous system; "autonomic reflexes"
PrepTutorEJDIC
- 自律神経の
UpToDate Contents
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English Journal
- Neck muscle afferents influence oromotor and cardiorespiratory brainstem neural circuits.
- Edwards IJ1, Lall VK, Paton JF, Yanagawa Y, Szabo G, Deuchars SA, Deuchars J.Author information 1School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, UK, i.j.edwards@leeds.ac.uk.AbstractSensory information arising from the upper neck is important in the reflex control of posture and eye position. It has also been linked to the autonomic control of the cardiovascular and respiratory systems. Whiplash associated disorders (WAD) and cervical dystonia, which involve disturbance to the neck region, can often present with abnormalities to the oromotor, respiratory and cardiovascular systems. We investigated the potential neural pathways underlying such symptoms. Simulating neck afferent activity by electrical stimulation of the second cervical nerve in a working heart brainstem preparation (WHBP) altered the pattern of central respiratory drive and increased perfusion pressure. Tracing central targets of these sensory afferents revealed projections to the intermedius nucleus of the medulla (InM). These anterogradely labelled afferents co-localised with parvalbumin and vesicular glutamate transporter 1 indicating that they are proprioceptive. Anterograde tracing from the InM identified projections to brain regions involved in respiratory, cardiovascular, postural and oro-facial behaviours-the neighbouring hypoglossal nucleus, facial and motor trigeminal nuclei, parabrachial nuclei, rostral and caudal ventrolateral medulla and nucleus ambiguus. In brain slices, electrical stimulation of afferent fibre tracts lateral to the cuneate nucleus monosynaptically excited InM neurones. Direct stimulation of the InM in the WHBP mimicked the response of second cervical nerve stimulation. These results provide evidence of pathways linking upper cervical sensory afferents with CNS areas involved in autonomic and oromotor control, via the InM. Disruption of these neuronal pathways could, therefore, explain the dysphagic and cardiorespiratory abnormalities which may accompany cervical dystonia and WAD.
- Brain structure & function.Brain Struct Funct.2014 Mar 5. [Epub ahead of print]
- Sensory information arising from the upper neck is important in the reflex control of posture and eye position. It has also been linked to the autonomic control of the cardiovascular and respiratory systems. Whiplash associated disorders (WAD) and cervical dystonia, which involve disturbance to the
- PMID 24595534
- A case of progressive multifocal leukoencephalopathy in a lupus patient treated with belimumab.
- Fredericks C1, Kvam K, Bear J, Crabtree G, Josephson S.Author information 11University of California San Francisco, San Francisco, USA.AbstractBelimumab is a monoclonal antibody against soluble B-lymphocyte stimulator, an essential growth factor for B-cell maturation and activation, which was approved by the US FDA in 2011 for patients with active autoantibody-positive systemic lupus erythematosus (SLE) who have failed standard treatment. Here we present the case of a 40-year-old woman with SLE diagnosed with progressive multifocal leukoencephalopathy (PML) on belimumab. After a total of 10 infusions of belimumab, from August 2012 through April 2013, in April 2013 she developed progressive neurologic decline with episodic dystonia and autonomic symptoms. Her imaging showed multifocal, confluent regions of T2 hyperintensity in the white matter bilaterally, and CSF JCV PCR returned positive. Based on the patient's clinically mild SLE and the timing of symptom onset, belimumab likely played a key role in the development of PML. Trials of belimumab for other autoimmune diseases are ongoing; as applications for this novel drug broaden, careful monitoring for this potentially fatal adverse effect is warranted.
- Lupus.Lupus.2014 Feb 14. [Epub ahead of print]
- Belimumab is a monoclonal antibody against soluble B-lymphocyte stimulator, an essential growth factor for B-cell maturation and activation, which was approved by the US FDA in 2011 for patients with active autoantibody-positive systemic lupus erythematosus (SLE) who have failed standard treatment.
- PMID 24531080
- Deep brain stimulation and autonomic control.
- Lovick T.Author information * Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK. thelma.lovick@bristol.ac.uk.AbstractNEW FINDINGS: What is the topic of this review? This article reviews data from studies on human participants and animal models showing how electrical stimulation in deep brain structures (deep brain stimulation) can influence autonomic function. What advances does it highlight? Focusing on the control of the cardiovascular system and bladder function, it highlights the potential for development of deep brain stimulation as a new treatment option for patients with autonomic dysfunction. Deep brain stimulation (DBS) in humans has come of age as a tool to treat movement disorders including Parkinson's disease tremor and dystonia as well as a panoply of other disease states including headache, epilepsy, obesity, eating disorders, depression, obsessive compulsive disorder, Tourette's syndrome, addiction and chronic pain. Increasingly, practitioners of DBS are reporting autonomic side effects, which intriguingly, sometimes result in improved autonomic function. Focussing on the effects of stimulation at periaqueductal and periventricular sites on cardiovascular function and control of micturition, this review shows that data obtained from studies in animals is now being confirmed in humans. Lowering of blood pressure and improved baroreflex function can be evoked in humans by DBS at these midbrain sites as well as increased bladder capacity. The findings highlight the tantalizing possibility that DBS could be developed for treatment of dysfunctional autonomic states in humans.
- Experimental physiology.Exp Physiol.2014 Feb;99(2):320-5. doi: 10.1113/expphysiol.2013.072694. Epub 2013 Sep 20.
- NEW FINDINGS: What is the topic of this review This article reviews data from studies on human participants and animal models showing how electrical stimulation in deep brain structures (deep brain stimulation) can influence autonomic function. What advances does it highlight Focusing on the contr
- PMID 24058185
Japanese Journal
- 自己免疫性脳症を見きわめるための新しい神経診察の提案—身体表現性障害との鑑別—
- モノアミン・ビオプテリン代謝改変マウスを用いたモノアミンニューロンの制御機構と発達変化の解析
Related Links
- 1. Introduction Paroxysmal autonomic instability with dystonia (PAID) syndrome is a relatively uncommon complication of various central nervous system (CNS) injuries. It has been reported in association with severe ...
- Contents Autonomic nerve symptoms AND Dystonia: Causes of All Symptoms Autonomic nerve symptoms OR Dystonia: 428 causes Autonomic nerve symptoms: 338 causes Autonomic nerve symptoms: Introduction Dystonia: 102 ...
★リンクテーブル★
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- 英
- autonomic imbalance、autonomic dystonia
- 関
- 自律神経失調症
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- 英
- autonomic dystonia, autonomic imbalance
- 同
- 植物神経失調症 vegetative dystonia、自律神経緊張異常症、自律神経不安定症 autonomic instability
- 関
- 自律神経機能検査法、自律神経失調
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- 英
- autonomic dystonia
- 関
- 自律神経失調症
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- 関
- autonomic dystonia
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- 関
- autonomous, autonomy, vegetativus