ascertainment artifact refers to data that seem to demonstrate some finding, but fail to do so because they are collected from a population that is selected in a biased fashion.

WordNet

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

Studying the evolution of transcription factor binding events using multi-species ChIP-Seq data.

Zheng W1, Zhao H.
Statistical applications in genetics and molecular biology.Stat Appl Genet Mol Biol.2013 Mar 26;12(1):1-15. doi: 10.1515/sagmb-2012-0004.
Recent technology advances make it possible to collect whole-genome transcription factor binding (TFB) profiles from multiple species through the ChIP-Seq data. This provides rich information to understand TFB evolution. However, few rigorous statistical models are available to infer TFB evolution f
PMID 23446869

Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension.

Larkin EK1, Newman JH, Austin ED, Hemnes AR, Wheeler L, Robbins IM, West JD, Phillips JA 3rd, Hamid R, Loyd JE.
American journal of respiratory and critical care medicine.Am J Respir Crit Care Med.2012 Nov 1;186(9):892-6. doi: 10.1164/rccm.201205-0886OC. Epub 2012 Aug 23.
RATIONALE: Analysis of the age of onset in heritable pulmonary arterial hypertension (HPAH) has led to the hypothesis that genetic anticipation causes younger age of onset and death in subsequent generations. With accrual of pedigree data over multiple decades, we retested this hypothesis using anal
PMID 22923661

Liu JJ1, Brooks JD, Ferrari M, Nolley R, Presti JC Jr.
The Journal of urology.J Urol.2011 Jun;185(6):2108-11. doi: 10.1016/j.juro.2011.02.053. Epub 2011 Apr 15.
PURPOSE: Prior radical prostatectomy series have shown an inverse association between prostate size and high grade cancer. It has been suggested that smaller size prostates arise in a low androgen environment, enabling development of more aggressive cancer. We propose that this observation is the re
PMID 21496855