アリールアミン-N-アセチルトランスフェラーゼ
WordNet
- the 14th letter of the Roman alphabet (同)n
PrepTutorEJDIC
- nitrogenの化学記号
- neodymiumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/10/26 12:18:39」(JST)
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arylamine N-acetyltransferase |
Identifiers |
EC number |
2.3.1.5 |
CAS number |
9027-33-2 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
In enzymology, an arylamine N-acetyltransferase (EC 2.3.1.5) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + an arylamine CoA + an N-acetylarylamine
Thus, the two substrates of this enzyme are acetyl-CoA and arylamine, whereas its two products are CoA and N-acetylarylamine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:arylamine N-acetyltransferase. Other names in common use include arylamine acetylase, beta-naphthylamine N-acetyltransferase, 4-aminobiphenyl N-acetyltransferase, acetyl CoA-arylamine N-acetyltransferase, 2-naphthylamine N-acetyltransferase, arylamine acetyltransferase, indoleamine N-acetyltransferase, N-acetyltransferase, p-aminosalicylate N-acetyltransferase, serotonin acetyltransferase, and serotonin N-acetyltransferase.
Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1GX3, 1W5R, 1W6F, 2BSZ, 2IJA, 2PFR, and 2PQT.
References
- CHOU TC, LIPMANN F (1952). "Separation of acetyl transfer enzymes in pigeon liver extract". J. Biol. Chem. 196 (1): 89–103. PMID 12980945.
- Paul RC, Ratledge C (1973). "Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes". Biochim. Biophys. Acta. 320 (1): 9–15. doi:10.1016/0304-4165(73)90160-8. PMID 4748369.
- Tabor H, Mehler AH and Stadtman ER (1953). "The enzymatic acetylation of amines". J. Biol. Chem. 204 (1): 127–138. PMID 13084583.
- Weissbach H, Redfield BG and Axelrod J (1961). "The enzymic acetylation of serotonin and other naturally occurring amines". Biochim. Biophys. Acta 54 (1): 190–192. doi:10.1016/0006-3002(61)90954-4. PMID 14005907.
UpToDate Contents
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English Journal
- Carbon Black Nanoparticles Impair Acetylation of Aromatic Amine Carcinogens through Inactivation of Arylamine N-Acetyltransferase Enzymes.
- Sanfins E, Dairou J, Hussain S, Busi F, Chaffotte AF, Rodrigues-Lima F, Dupret JM.SourceUniv Paris Diderot, Sorbonne Paris Cite, Unite de Biologie Fonctionnelle et Adaptative, CNRS EAC4413, 75013, Paris, France.
- ACS nano.2011 May 3. [Epub ahead of print]
- Carbon black nanoparticles (CB NPs) and their respirable aggregates/agglomerates are classified as possibly carcinogenic to humans. In certain industrial work settings, CB NPs coexist with aromatic amines (AA), which comprise a major class of human carcinogens. It is therefore crucial to characteriz
- PMID 21526848
- Liver-Selective Expression of Human Arylamine N-Acetyltransferase NAT2 in Transgenic Mice.
- Sugamori KS, Brenneman D, Grant DM.SourceDepartment of Pharmacology and Toxicology, University of Toronto, Room 4316 Medical Sciences Building, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. denis.grant@utoronto.ca.
- Drug metabolism and disposition: the biological fate of chemicals.2011 May;39(5):882-90. Epub 2011 Feb 11.
- Human arylamine N-acetyltransferase 2 (NAT2) mediates the biotransformation of arylamine drugs and procarcinogens into either innocuous or reactive DNA-damaging metabolites and is expressed predominantly in liver. Interspecies differences and incongruous results between in vitro, in vivo, and epidem
- PMID 21317369
Japanese Journal
- Gene cloning and characterization of arylamine N-acetyltransferase from Bacillus cereus strain 10-L-2(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Takenaka Shinji,Cheng Minyi,Mulyono,Koshiya Atsushi,Murakami Shuichiro,Aoki Kenji
- Journal of bioscience and bioengineering 107(1), 27-32, 2009-01
- … Bacillus cereus strain 10-L-2 synthesizes two arylamine N-acetyltransferases (Nat-a and Nat-b) with broad substrate specificities toward aniline and its derivatives. … In southern blot analysis using probes encoding the NH_2-terminus of Nat-b and a conserved region of N-acetyltransferases, digested total DNA of strain 10-L-2 showed one positive band. …
- NAID 110007042020
- Polymorphisms of promoter and coding regions of the arylamine N-acetyltransferase 2 (NAT2) gene in the Indonesian population : proposal for a new nomenclature
- YULIWULANDARI Rika,SACHROWARDI Qomariyah,NISHIDA Nao,TAKASU Miwa,BATUBARA Lilian,SUSMIARSIH Tri Panjiasih,ROCHANI Jecti Teguh,WIKANINGRUM Riyani,MIYASHITA Risa,MIYAGAWA Taku,SOFRO Abdul Salam Mudzakir,TOKUNAGA Katsushi
- Journal of human genetics 53(3), 201-209, 2008-03-01
- NAID 10021248101
Related Links
- In enzymology, an arylamine N-acetyltransferase (EC 2.3.1.5) is an enzyme that catalyzes the chemical reaction. acetyl-CoA + an arylamine \ ... The systematic name of this enzyme class is acetyl-CoA:arylamine N-acetyltransferase. ...
Related Pictures
★リンクテーブル★
[★]
- 英
- arylamine N-acetyltransferase
- 関
- アリールアミン-N-アセチルトランスフェラーゼ
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- 英
- arylamine N-acetyltransferase
- 関
- アリールアミンN-アセチルトランスフェラーゼ
[★]
アセチルトランスフェラーゼ、アセチル基転移酵素、アセチル化酵素
- 関
- transacetylase
[★]
- 関
- number of experiment、sample size
- pの前の[n]はmと記載する。synptom→symptom
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[★]
ネオジム neodymium