WordNet

of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
(weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
an organic compound containing only carbon and hydrogen

PrepTutorEJDIC

『核の』,細胞核の / [『原子』]『核の』
=sense organ / 受信装置
炭化水素(水素と炭素のみを含む化学物の総称)
are (面積の単位)の変形

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/09 08:16:46」(JST)

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The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.

The aryl hydrocarbon receptor (AhR) is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the aryl hydrocarbon receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound AhR to xenobiotic responsive elements in the promoters of genes for these enzymes.

Interactions

Aryl hydrocarbon receptor nuclear translocator has been shown to interact with:

AIP,^[1]^[2]
AHR,^[3]^[4]^[5]^[6]
EPAS1,^[7]
HIF1A,^[7]^[8]
NCOA2,^[9]^[9]
SIM1,^[8]^[10] and
SIM2.^[8]^[10]^[11]^[12]

References

^ Carver LA, Bradfield CA (April 1997). "Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo". J. Biol. Chem. 272 (17): 11452–6. doi:10.1074/jbc.272.17.11452. PMID 9111057.
^ Kazlauskas A, Sundström S, Poellinger L, Pongratz I (April 2001). "The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor". Mol. Cell. Biol. 21 (7): 2594–607. doi:10.1128/MCB.21.7.2594-2607.2001. PMC 86890. PMID 11259606.
^ Lindebro MC, Poellinger L, Whitelaw ML (July 1995). "Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex". EMBO J. 14 (14): 3528–39. PMC 394421. PMID 7628454.
^ Whitelaw M, Pongratz I, Wilhelmsson A, Gustafsson JA, Poellinger L (April 1993). "Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor". Mol. Cell. Biol. 13 (4): 2504–14. PMC 359572. PMID 8384309.
^ Yamaguchi Y, Kuo MT (October 1995). "Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system". Biochem. Pharmacol. 50 (8): 1295–302. doi:10.1016/0006-2952(95)02016-6. PMID 7488247.
^ Mimura J, Ema M, Sogawa K, Fujii-Kuriyama Y (January 1999). "Identification of a novel mechanism of regulation of Ah (dioxin) receptor function". Genes Dev. 13 (1): 20–5. doi:10.1101/gad.13.1.20. PMC 316371. PMID 9887096.
^ ^a ^b Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA (March 1997). "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway". J. Biol. Chem. 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689.
^ ^a ^b ^c Woods SL, Whitelaw ML (March 2002). "Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". J. Biol. Chem. 277 (12): 10236–43. doi:10.1074/jbc.M110752200. PMID 11782478.
^ ^a ^b Beischlag TV, Wang S, Rose DW, Torchia J, Reisz-Porszasz S, Muhammad K, Nelson WE, Probst MR, Rosenfeld MG, Hankinson O (June 2002). "Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex". Mol. Cell. Biol. 22 (12): 4319–33. doi:10.1128/mcb.22.12.4319-4333.2002. PMC 133867. PMID 12024042.
^ ^a ^b Probst MR, Fan CM, Tessier-Lavigne M, Hankinson O (February 1997). "Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein". J. Biol. Chem. 272 (7): 4451–7. doi:10.1074/jbc.272.7.4451. PMID 9020169.
^ Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H (January 2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression". Mol. Cell. Biol. 24 (2): 608–16. doi:10.1128/mcb.24.2.608-616.2004. PMC 343817. PMID 14701734.
^ Moffett P, Reece M, Pelletier J (September 1997). "The murine Sim-2 gene product inhibits transcription by active repression and functional interference". Mol. Cell. Biol. 17 (9): 4933–47. doi:10.1128/mcb.17.9.4933. PMC 232345. PMID 9271372.

External links

Aryl Hydrocarbon Receptor Nuclear Translocator at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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1. 炭化水素中毒 hydrocarbon poisoning
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English Journal

Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation.

Hao N, Bhakti VL, Peet DJ, Whitelaw ML.SourceSchool of Molecular and Biomedical Science (Biochemistry), The University of Adelaide, Adelaide, South Australia 5005, Australia.
Nucleic acids research.Nucleic Acids Res.2013 Apr 17. [Epub ahead of print]
Basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factors function broadly in development, homeostasis and stress response. Active bHLH/PAS heterodimers consist of a ubiquitous signal-regulated subunit (e.g., hypoxia-inducible factors, HIF-1α/2α/3α; the aryl hydrocarbon receptor, AhR)
PMID 23599003

Modulation of aryl hydrocarbon receptor target genes in circulating lymphocytes from dairy cows bred in a dioxin-like PCB contaminated area.

Girolami F, Spalenza V, Carletti M, Sacchi P, Rasero R, Nebbia C.SourceDepartment of Animal Pathology, University of Turin, Via Leonardo da Vinci 44, 10095 Grugliasco, Italy. Electronic address: flavia.girolami@unito.it.
The Science of the total environment.Sci Total Environ.2013 Apr 15;450-451:7-12. doi: 10.1016/j.scitotenv.2013.01.095. Epub 2013 Feb 27.
Animal productions (i.e. fish, eggs, milk and dairy products) represent the major source of exposure to dioxins, furans, and dioxin-like (DL) polychlorobiphenyls for humans. The negative effects of these highly toxic and persistent pollutants are mediated by the activation of the aryl hydrocarbon re
PMID 23454571

Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1β gene expression in pancreatic islet β-cells.

Nakabayashi H, Ohta Y, Yamamoto M, Susuki Y, Taguchi A, Tanabe K, Kondo M, Hatanaka M, Nagao Y, Tanizawa Y.SourceYamaguchi University, Graduate School of Medicine, Division of Endocrinology, Metabolism, Hematological Sciences and Therapeutics, Department of Bio-Signal Analysis, Ube, Yamaguchi 755-8505, Japan.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2013 Apr 6. pii: S0006-291X(13)00548-2. doi: 10.1016/j.bbrc.2013.03.084. [Epub ahead of print]
Aryl hydrocarbon receptor nuclear translocator (ARNT)/hypoxia-inducible factor-1β (HIF1-β) has emerged as a potential determinant of pancreatic β-cell dysfunction and type 2 diabetes in humans. An 82% reduction in Arnt expression was observed in islets from type 2 diabetic donors as compared to n
PMID 23567972

Japanese Journal

Aryl hydrocarbon receptor nuclear translocator in human liver is regulated by miR-24

Oda Yuki,Nakajima Miki,Mohria Takuya,Takamiya Masataka,Aoki Yasuhiro,Fukami Tatsuki,Yokoi Tsuyoshi
Toxicology and Applied Pharmacology 260(3), 222-231, 2012-05-01
… Aryl hydrocarbon receptor nuclear translocator (ARNT) forms a heterodimer with aryl hydrocarbon receptor or hypoxia inducible factor 1α to mediate biological responses to xenobiotic exposure and hypoxia. …
NAID 120004161531

Molecular evidence predicts aryl hydrocarbon receptor ligand insensitivity in the peregrine falcon (Falco peregrines)

Fujisawa Nozomi,Ikenaka Yoshinori,Kim Eun-Young,Lee Jin-Seon,Iwata Hisato,Ishizuka Mayumi
European Journal of Wildlife Research 58(1), 167-175, 2012-02
… It has been demonstrated that TCDD-like chemicals cause toxic effects via aryl hydrocarbon receptor (AHR)-mediated signaling pathways. … The AHR1, AHR2, and AHR nuclear translocator (ARNT) 1 of the peregrine falcon are more similar in amino acid sequence to avian species less sensitive to TCDD-like chemicals such as the cormorant (95%) than to more sensitive species such as the chicken (90%). …
NAID 120005183149

All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells

Ohno Marumi,Ikenaka Yoshinori,Ishizuka Mayumi
Biochemical and Biophysical Research Communications 417(1), 484-489, 2012-01-06
… Aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT) are well-conserved transcription factors among species. …
NAID 80022251914

★リンクテーブル★

リンク元	「アリール炭化水素受容体核内輸送体」
関連記事	「nuclear」「translocator」「aryl hydrocarbon」

「アリール炭化水素受容体核内輸送体」

Aryl hydrocarbon receptor nuclear translocator
	PDB rendering based on 1x0o.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1D7G, 1X0O, 2A24, 2ARN, 2B02, 2HV1, 2K7S, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4EQ1, 4GHI, 4GS9, 4H6J, 4LPZ, 4PKY
Identifiers
Symbols	ARNT ; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO; bHLHe2
External IDs	OMIM: 126110 MGI: 88071 HomoloGene: 1261 ChEMBL: 5618 GeneCards: ARNT Gene
Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • transcription coactivator activity; • aryl hydrocarbon receptor activity; • protein binding; • transcription factor binding; • aryl hydrocarbon receptor binding; • enhancer binding; • sequence-specific DNA binding; • protein heterodimerization activity;
Cellular component	• nucleus; • nucleoplasm; • cytoplasm; • RNA polymerase II transcription factor complex;
Biological process	• response to hypoxia; • embryonic placenta development; • positive regulation of endothelial cell proliferation; • transcription, DNA-templated; • positive regulation of vascular endothelial growth factor production; • cell differentiation; • intracellular receptor signaling pathway; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • positive regulation of protein sumoylation; • mRNA transcription from RNA polymerase II promoter; • regulation of transcription from RNA polymerase II promoter in response to oxidative stress; • positive regulation of erythrocyte differentiation; • positive regulation of glycolytic process; • positive regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of hormone biosynthetic process; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • cellular response to hypoxia;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;