artificial insemination by donor

• 非配偶者間人工授精

WordNet

1. so as to pass a given point; "every hour a train goes past" (同)past
2. not arising from natural growth or characterized by vital processes
3. artificially formal; "that artificial humility that her husband hated"; "contrived coyness"; "a stilted letter of acknowledgment"; "when people try to correct their speech they develop a stilted pronunciation" (同)contrived, hokey, stilted
4. contrived by art rather than nature; "artificial flowers"; "artificial flavoring"; "an artificial diamond"; "artificial fibers"; "artificial sweeteners" (同)unreal
5. person who makes a gift of property (同)giver, presenter, bestower, conferrer
6. (medicine) someone who gives blood or tissue or an organ to be used in another person (the host)
7. the head of an organized crime family (同)father
8. the act of sowing (of seeds in the ground or, figuratively, of germs in the body or ideas in the mind, etc.)
9. the introduction of semen into the genital tract of a female

PrepTutorEJDIC

1. 《場時・位置》…『のそばに』,の近くに;…の手もとに / 《経路・通過》…を経由して,を通って,のそばを通って / 《期限・期間》…『までに』,『の間に』 / 《根拠・理由》…『によって』,に従って,に基づいて / …『を単位として』 / 《差・程度》…だけ / 《手段・方法》…『で』,『によって』,を使って / …が原因で,…の結果 / 《動作を受ける部分を示して》…を,のところを / 《受動態で動作の主体を表して》『…によって』 / …に関しては,については / …に誓って,の名において,にかけて / …ずつ,ごとに,の順番に / 《寸法・乗除》…で;…を / …に対して,のために / 《訪問場所》…に / 『そばに』,近くに / そばを通って / わきへ,取りのけて / 《時の経過》過ぎて
2. 『人造の』,『人工の』,人為的な / 模造の / 不自然な,見せかけの
3. 寄付者,寄贈者 / (移植用の組織・器官の)提供者,献血者
4. 《Don》ドン(Sirに当たるスペイン語で男性の洗礼名の前につける) / 〈C〉スペイン貴族(紳士) / 〈C〉(オックスフォード・ケンブリッジ両大学の)学監,指導教授 / 〈C〉《英》大学教師
5. 〈衣服〉‘を'着る,〈帽子〉‘を'かぶる[do onの短縮形]
6. 受精

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/07/25 05:29:28」(JST)

wiki en

[Wiki en表示]

Sperm donation is the provision (or ‘donation’) by a man, (known as a ‘sperm donor’), of his sperm, with the intention that it be used to impregnate a woman who is not his sexual partner. While the sperm donor is the natural or biological father of every child produced as a result of his donations, he is generally not intended to be the legal or de jure father. Depending on the jurisdiction and its laws, he may or may not later be eligible to seek parental rights or be held responsible for parental obligations.

Sperm is often donated through a sperm bank or clinic, which are subject to varying state regulations, including restrictions on donor anonymity and number of offspring. By having sperm provided privately and directly to the intended mother, donors and recipients may avoid legal restrictions but also lose the benefit of legal protections of recipient and donor rights and responsibilities.

Heterosexual couples suffering from male infertility, lesbian couples, and single women are the primary recipients of donor sperm. When going through a sperm bank, they may select their donor on the grounds of looks, personality, academic ability, race, and many other factors. Some sperm banks, either by choice or regulation, limit the amount of information available to potential recipients; a desire to obtain more information on donors is one reason why recipients may choose to use a known donor and/or private donation.

Pregnancies are usually achieved using donated sperm by artificial insemination (either by ICI or IUI in a clinic, or Intravaginal Insemination at home) and less commonly by in vitro fertilization (IVF), usually known in this context as ART but insemination may also be achieved by a donor having sexual intercourse with a woman for the sole purpose of initiating conception. This method is known as natural insemination, or NI.

The general process of sperm donation is described as third party reproduction.

Laws

Main article: Sperm donation laws by country

Laws regulating sperm donation address issues such as:

• Permissible reimbursement or payment
  • Is it legal to pay for sperm?
  • Is there a maximum payment?
• Rights and responsibilities of the donor towards his biological offspring
  • When, if ever, can a donor be held liable for child support?
  • When, if ever, can a donor have the right be part of the child's life?
• Anonymity of sperm donors
  • Does a child have a right to know any information about their biological father, including that they were born via sperm donation?
  • What, if any, obligations does a donor have to provide ongoing information about himself and his health?
• Other regulation of non-private sperm donation
  • What medical, hygiene, and record-keeping procedures must clinics follow?
  • Is there a maximum number of offspring a donor can create?

Laws vary greatly from jurisdiction to jurisdiction.

In general, laws are more likely disregard the sperm donor's biological link to the child, so that he will neither have child support obligations nor rights to the child, when sperm donation happens in a clinical setting and/or under medical supervision. Absent specific legal protection, courts may order the sperm donor to pay child support or recognize his parental rights.

Uses

Donated sperm may be prepared for use by artificial insemination in intrauterine insemination (IUI) or intra-cervical insemination (ICI), or, less commonly, it may be prepared for use in other assisted reproductive techniques such as IVF and ICSI. Donated sperm may also be used in surrogacy arrangements either by artificially inseminating the surrogate with donor sperm (known as traditional surrogacy) or by implanting in a surrogate embryos which have been created by using donor sperm together with eggs from a donor or from the 'commissioning woman' ( known as gestational surrogacy). Spare embryos from this process may be donated to other women or surrogates. Donor sperm may also be used for producing embryos with donated eggs which are then donated to a woman who is not genetically related to the child she produces.

In medical terms, using donor sperm to achieve a pregnancy in IVF or ICSI is no different from using sperm from a woman's partner.

Provision

Men may donate sperm privately or through a sperm bank, sperm agency, or other brokerage arrangement. Private donors most commonly choose artificial insemination, and natural insemination is also an option.

Generally, a man who provides sperm as a sperm donor gives up all legal and other rights over the biological children produced from his sperm. However, in private arrangements, some degree of co-parenting may be agreed upon, and the enforceability of those agreements varies by jurisdiction.

Donors may or may not be paid for the donation, according to local laws and agreed arrangements. Even in unpaid arrangements, expenses are often reimbursed.

Depending on local law and on private arrangements, men may donate anonymously or agree to provide identifying information to their offspring in the future. Private donations facilitated by an agency often use a "directed" donor, when a man directs that his sperm to be used by a specific person. Non-anonymous donors are also called "known donors", "open donors" or "identity disclosure donors".

Sperm banks

Main article: Sperm bank

In a sperm bank, the donor will usually donate sperm for a specified contractual period of time generally ranging from six to twenty-four months depending on the number of pregnancies which the sperm bank intends to produce from the donor. However, not all donors complete the intended programme of donations. If a sperm bank has access to world markets e.g. by direct sales, or sales to clinics outside their own jurisdiction, a man may donate for a longer period than two years, as the risk of consanguinity is reduced (although local laws vary widely). The agreement or contract between the donor and the sperm bank will usually contain provisions about the place and hours for donation, a requirement to notify the sperm bank in the case of acquiring a sexual infection, and the requirement not to have intercourse or to masturbate for a period of usually 2–3 days before making a donation.

To donate sperm a man must generally meet specific requirements regarding age and medical history. In the United States, sperm banks are regulated as Human Cell and Tissue or Cell and Tissue Bank Product (HCT/Ps) establishments by the Food and Drug Administration. Many states also have regulations in addition to those imposed by the FDA. In the European Union a sperm bank must have a license according to the EU Tissue Directive. In the UK sperm banks are regulated by the Human Fertilisation and Embryology Authority.

Sperm agencies

In some jurisdictions, sperm may also be donated through an agency rather than through a sperm bank. The agency recruits sperm donors, usually via the Internet, and it also advertises its services on the Internet. Donors may undergo the same kind of checks and tests required by a sperm bank, although clinics and agencies are not necessarily subject to the same regulatory regimes. In the case of an agency, the sperm will be supplied to the recipient woman fresh rather than frozen.

A woman chooses a donor and notifies the agency when she requires donations. The agency notifies the donor who must supply his sperm on the appropriate days nominated by the recipient women. The agency will usually provide the sperm donor with a male collection kit usually including a collection condom and a container for shipping the sperm. This is collected and delivered by courier and the woman uses the donor's sperm to perform her own artificial insemination, typically without medical supervision. The whole process preserves the anonymity of the parties and it enables a donor to produce sperm in the privacy of his own home. A donor will generally produce samples once or twice during a recipient's fertile period, but a second sample each time may not have the same fecundity of the first sample because it is produced too soon after the first one. Pregnancy rates by this method of sperm donation may vary more than those achieved by sperm banks or fertility clinics. Transit times may vary and these have a significant effect on sperm viability so that if a donor is not located near to a recipient woman the sperm may deteriorate. However, the use of fresh, as opposed to frozen semen will mean that a sample has a greater fecundity and this can produce higher pregnancy rates.

Sperm agencies may impose limits on the number of pregnancies achieved from each donor but in practice this is more difficult to achieve than for sperm banks where the whole process may be more regulated. Most sperm donors only donate for a limited period however, and since sperm supplied by a sperm agency is not processed into a number of different vials, there is a practical limit on the number of pregnancies which are usually produced in this way. A sperm agency will, for the same reason, be less likely than a sperm bank to enable a woman to have subsequent children by the same donor.

Sperm agencies are largely unregulated and, because the sperm is not quarantined, it may carry sexually transmitted diseases. This lack of regulation has led to the competent authorities in some jurisdictions bringing legal action against sperm agencies in certain cases. Agencies typically insist on STI testing for donors, but such tests cannot detect recently-acquired infections. Donors providing sperm in this way may not be protected by laws which apply to donations through a sperm bank or fertility clinic and will, if traced, be regarded as the legal father of each child produced by their sperm, (but see below, Private donors).

Private or "directed" donors

Some donors and recipients choose to arrange donations privately and directly. Recipients may approach a friend, or may obtain a "private" or "directed" donor by advertising. A number of Web sites seek to link such donors and recipients, while advertisements in gay and lesbian publications are common. Although artificial insemination is usually used, the parties may sometimes agree to inseminate naturally (see 'NI and sperm donation below'). Where a private or directed donor is used, sperm need not be frozen. Such donors may already know the recipients, or if arranged through a broker, may meet the recipients and may therefore become known to the recipient. Some brokerage services facilitate contact that maintains semi-anonymous identities for legal reasons.

Private donations may be free of charge - avoiding the significant costs of a more medicalised insemination - and fresh rather than frozen semen is generally deemed to increase the chances of pregnancy. However, they also carry the higher risks associated with any unscreened sexual or body fluid contact. Legal treatment of donors varies across jurisdictions, and in most jurisdictions, e.g., Sweden, personal and directed donors lack legal safeguards that may be available to anonymous donors. However, the laws of some nations (e.g., New Zealand), recognize written agreements between donors and recipients in a similar way to institutional donations.

Natural Insemination

Where a donor inseminates a woman through sexual intercourse with her for the sole reason of enabling the woman to achieve a pregnancy, this is known as natural insemination or "NI".

A 'natural' conception avoids the need to be subjected to medical procedures that may or may not involve the intervention of third parties. It lacks the safety precautions and screenings usually built in to the artificial insemination process. Proponents claim that it produces higher pregnancy rates.

While rarely used, some private sperm donors now offer NI as an alternative to the use of artificial means, or they will do so after attempts to achieve a conception by artificial insemination have failed, and an increasing number of women are seeking a natural conception from a donor.

Sperm Bank Processes

A man donates sperm at a clinic or sperm bank by way of masturbation in a private room or cabin, known as a 'men's production room' (UK), 'donor cabin' (DK) or a masturbatorium (USA). Many of these facilities contain pornography such as videos/DVD, magazines, and/or photographs which may assist the donor in becoming stimulated in order to facilitate production of the ejaculate, also known as the 'semen sample'. In some circumstances, it may also be possible for donors to ejaculate during sexual intercourse, and use a condom to collect the sperm.

Preparing the sperm

Clinics and sperm banks usually 'wash' the sample so that sperm may be extracted from the rest of the material in the semen. A cryoprotectant semen extender is added if the sperm is to be placed in frozen storage in liquid nitrogen, and the sample is then frozen in a number of vials or straws. One sample will be divided into 1-20 vials or straws depending on the quantity of the ejaculate and whether the sample is 'washed' or 'unwashed'. Following the necessary quarantine period, the samples will be thawed and used to impregnate women through artificial insemination or other ART treatments. 'Unwashed' samples are used for ICI treatments, and 'washed' samples are used in IUI and IVF procedures.

Medical issues

Screening

Sperm banks typically screen every potential donor for genetic diseases, chromosomal abnormalities and sexually transmitted infections that may be transmitted through sperm.

In the US, the screening procedures are regulated by the FDA, the ASRM, the American Association of Tissue Banks, and the CDC. The screening regulations are more stringent today than they have been in the past. In Europe, the screening procedure are regulated by the EU Tissue Directive.

Screening includes:

• Taking a medical history of the donor, his children, siblings, parents, and grandparents etc. for three to four generations back. This is often done in conjunction with the patient's family doctor.
• HIV risk assessment interview, asking about sexual activity and any past drug use.
• Blood tests and urine tests for infectious diseases, such as:
  • HIV-1/2 see sections below
  • HTLV-1/2
  • Hepatitis B
  • Hepatitis C
  • Syphilis
  • Gonorrhea
  • Chlamydia
  • Cytomegalovirus (CMV) see sections below, although not all clinics test for this.
• Blood and urine tests for blood typing and general health indicators: ABO/Rh typing, CBC, liver panel and urinalysis
• Complete physical examination including careful examination of the penis, scrotum and testicles.
• Genetic testing for carrier traits, for example:
  • Cystic Fibrosis
  • Sickle-cell disease
  • Thalassemia
  • Other hemoglobin-related blood disorders.

Cystic fibrosis carrier screening, chromosome analyses, and hemoglobin evaluations are performed on the majority of sperm donor applicants in the United States. Donors of Jewish, Québécois, or Cajun descent may also get genetic testing for the carrier trait of Tay Sachs disease, but there is significant variation in screening for other disorders that occur with increased frequency in this population.

• General health
• Semen analysis for:
  • Sperm count
  • Morphology
  • Motility
  • Acrosome activity may also be tested

Quarantine

The samples are generally frozen and stored for at least 6 months after which the donor will be re-tested for the STIs. This is to ensure no new infections have been acquired or have developed during the period of donation. Providing the result is negative, the sperm samples can be released from quarantine and used in treatments.

Washing techniques are developing that purify sperm from viral load of HIV and hepatitis C., but nevertheless clinics do not offer sperm from carriers of significant STIs.

Cytomegalovirus

Screening for cytomegalovirus is not mandatory in all jurisdictions, and positive donors may still donate at sperm banks.

Donor screening for cytomegalovirus (CMV) is carried out by testing for IgG antibodies against CMV that are produced if the donor ever has contracted CMV, which is the case in between 50% and 80% of adults. Such antibody-positive individuals may potentially shed virus that remain latent in the body in the semen, infecting the mother and, in turn, the embryo/fetus. Most babies will not be harmed by the virus, but a small percentage may develop neurological abnormalities. However, the risk of acquiring CMV infection from an antibody-positive sperm donor is believed to be extremely low, at least where sperm banks perform follow-up tests on antibody-positive donors for type IgM antibodies that indicate current or recent CMV infection, and where sperm preparations are performed that decrease the amount of white blood cells in the samples, e.g. in samples prepared for IUI. In uncertainty, recipient women may do a blood sample test on themselves for IgG antibodies at their health care provider, determining immunity against the virus.

Sperm donation and reduced birth defects

See also: Sperm quality and Paternal age effect

Children conceived through sperm donation have a birth defect rate of almost a fifth compared with the general population. This may be explained by the fact that sperm banks only accept donors who have good semen quality, and because of the rigorous screening procedures which they adopt, including a typical age limitation on sperm donors, often limiting sperm donors to the ages of 21-39 (see paternal age effect), and genetic and health screening of donors. In addition, sperm banks may try to ensure that the sperm used in a particular recipient woman comes from a donor whose blood group and genetic profile is compatible with those of the woman.

Sperm donation and rhesus incompatibility

Sperm donation is also used in cases of rhesus incompatibility. This particularly occurs where a woman has a blood type which is rhesus negative, and where her partner is rhesus positive. The woman's body may reject a fetus if it has rhesus positive blood. Anti D injections have been developed and may be used to attempt to avoid this, and these are usually automatically given to rhesus negative women immediately after they give birth to their first child. However, in the past this was either not possible or was not always routinely undertaken where a woman gave birth or had an abortion and she may have trouble carrying a child later in life. Furthermore, for some women, the anti D injection does not provide the entire solution, particularly where there is a medical history of complications during pregnancy which risk the woman's blood and that of the fetus becoming mixed. In such cases, sperm from a rhesus negative donor can provide the solution and a woman may be able to conceive and carry a pregnancy to full term when otherwise this would not be possible. For this reason, sperm from rhesus negative sperm donors is often in great demand, particularly those with the O negative blood group who are universal donors.

Samples required per donor offspring

The number of donor samples (ejaculates) that are required to help give rise to a child varies substantially from donor to donor, as well as from clinic to clinic.

However, the following equations generalize the main factors involved:

For intracervical insemination:

Approximate pregnancy rate (r_s) varies with amount of sperm used in a cycle (n_r). Values are for intrauterine insemination, with sperm number in total sperm count, which may be approximately twice the total motile sperm count. (Old data, rates are likely higher today)

N is how many children a single sample can help give rise to.

V_s is the volume of a sample (ejaculate), usually between 1.0 mL and 6.5 mL

c is the concentration of motile sperm in a sample after freezing and thawing, approximately 5-20 million per ml but varies substantially

r_s is the pregnancy rate per cycle, between 10% to 35%

n_r is the total motile sperm count recommended for vaginal insemination (VI) or intra-cervical insemination (ICI), approximately 20 million pr. ml.

The pregnancy rate increases with increasing number of motile sperm used, but only up to a certain degree, when other factors become limiting instead.

For derivation of the equation, see Artificial insemination#Samples per child.

With these numbers, one sample would on average help giving rise to 0.1-0.6 children, that is, it actually takes on average 2-5 samples to make a child.

For intrauterine insemination, a centrifugation fraction (f_c) may be added to the equation:

f_c is the fraction of the volume that remains after centrifugation of the sample, which may be about half (0.5) to a third (0.33).

On the other hand, only 5 million motile sperm may be needed per cycle with IUI (n_r=5 million)

Thus, only 1-3 samples may be needed for a child if used for IUI.

Using ART treatments such as IVF can result in one donor sample (or ejaculate) producing on average considerably more than one birth. However, the actual number of births per sample will depend on the actual ART method used, the age and medical condition of the woman bearing the child, and the quality of the embryos produced by fertilization. Donor sperm is less commonly used for IVF treatments than for artificial insemination. This is because IVF treatments are usually required only when there is a problem with the female conceiving, or where there is a 'male factor problem' involving the woman's partner. Donor sperm is also used for IVF in surrogacy arrangements where an embryo may be created in an IVF procedure using donor sperm and this is then implanted in a surrogate. In a case where IVF treatments are employed using donor sperm, surplus embryos may be donated to other women or couples and used in embryo transfer procedures. When donor sperm is used for IVF treatments, there is a risk that large numbers of children will be born from a single donor, and many sperm banks therefore limit the amount of semen from each donor which is prepared for IVF use, or they may restrict the period of time for which such a donor donates his sperm to perhaps as little as three months (about nine or ten ejaculates).

Choosing donors

Information about donor

In the US, sperm banks maintain lists or catalogues of donors which provide basic information about the donor such as racial origin, skin color, height, weight, colour of eyes, and blood group. Some of these catalogues are available for browsing via the Internet, while others are only made available to patients when they apply to a sperm bank for treatment. Some sperm banks make additional information about each donor available for an additional fee, and others make additional basic information known to children produced from donors when those children reach the age of eighteen. Some clinics offer "exclusive donors" whose sperm is only used to produce pregnancies for one recipient woman. How accurate this is, or can be, is not known, and neither is it known whether the information produced by sperm banks, or by the donors themselves, is true. Many sperm banks will, however, carry out whatever checks they can to verify the information they request, such as checking the identity of the donor and contacting his own doctor to verify medical details. Simply because such information is not verifiable does not imply that it is in any way inaccurate, and a sperm bank will rely upon its reputation which, in turn, will be based upon its success rate and upon the accuracy of the information about its donors which it makes available.

In the UK, most donors are anonymous at the point of donation and recipients can only see non-identifying information about their donor (height, weight, ethnicity etc.). Donors need to provide identifying information to the clinic and clinics will usually ask the donor's GP to confirm any medical details they have been given. Donors are asked to provide a pen portrait of themselves which is held by the HFEA and can be obtained by the adult conceived from the donation at the age of 18, along with identifying information such as the donor's name and last known address. Known donation is permitted and it is not uncommon for family or friends to donate to a recipient couple.

Other screening criteria

Sexually active gay men are prohibited or discouraged from donating in some countries, including the United States. Some sperm banks also screen out some potential donors based on height, baldness, and family medical history.

Number of offspring

Further information: Sperm donation laws by country

Where a sperm donor donates sperm through a sperm bank, the sperm bank will generally undertake a number of medical and scientific checks to ensure that the donor produces sperm of sufficient quantity and quality and that the donor is healthy and will not pass diseases through the use of his sperm. The donor's sperm must also withstand the freezing and thawing process necessary to store and quarantine the sperm. The cost to the sperm bank for such tests is considerable. This normally means that clinics may use the same donor to produce a number of pregnancies in a number of different women.

The number of children permitted to be born from a single donor varies according to law and practice. These laws are designed to protect the children produced by sperm donation from consanguinity in later life: they are not intended to protect the sperm donor himself and those donating sperm will be aware that their donations may give rise to numerous pregnancies in different jurisdictions. Such laws, where they exist, vary from state to state, and a sperm bank may also impose its own limits. The latter will be based on the reports of pregnancies which the sperm bank receives, although this relies upon the accuracy of the returns and the actual number of pregnancies may therefore be somewhat higher. Nevertheless, sperm banks frequently impose a lower limit on geographical numbers than some US states and may also limit the overall number of pregnancies which are permitted from a single donor. When calculating the numbers of children born from each donor, the number of siblings produced in any 'family' as a result of sperm donation from the same donor are almost always excluded.

Further information: Sperm donation laws by country

There is, of course, no limit to the number of offspring which may be produced from a single donor where he supplies his sperm privately.

Despite the laws limiting the number of offspring, some donors may produce substantial numbers of children, particularly where they donate through different clinics, where sperm is onsold or is exported to different jurisdictions, and where countries or states do not have a central register of donors.

Sperm agencies, in contrast to sperm banks, rarely impose or enforce limits on the numbers of children which may be produced by a particular donor partly because they are not empowered to demand a report of a pregnancy from recipients and they are rarely, if ever, able to guarantee that a woman may have a subsequent sibling by the donor who was the biological father of her first or earlier children.

Siblings

Where a woman wishes to have additional children by sperm donation, she will often wish to have these by the same donor. The advantage of having subsequent children by the same donor is that these will be full biological siblings, having the same biological father and mother. Many sperm banks offer a service of storing sperm for future pregnancies, but few will otherwise guarantee that sperm from the original donor will be available in the future.

Sperm banks rarely impose limits on the numbers of second or subsequent siblings. Even where there are limits on the use of sperm by a particular donor to a defined number of families (as in the UK) the actual number of children produced from each donor will often be far greater.

Donor payment

The majority of sperm donors who donate their sperm through a sperm bank receive some kind of payment, although this is rarely a significant amount. The payments vary from the situation in the United Kingdom where donors are only entitled to their expenses in connection with the donation, to the situation with some US sperm banks where a donor receives a set fee for each donation plus an additional amount for each vial stored. At one prominent California sperm bank for example, TSBC, donors receive roughly $50 for each donation (ejaculation) which has acceptable motility/survival rates both at donation and at a test-thaw a couple of days later. Because of the requirement for the two-day celibacy period before donation, and geographical factors which usually require the donor to travel, it is not a viable way to earn a significant income—and is far less lucrative than selling human eggs. Some private donors may seek remuneration although others donate for altruistic reasons. According to the EU Tissue Directive donors in EU may only receive compensation, which is strictly limited to making good the expenses and inconveniences related to the donation. A survey among sperm donors in Cryos International Sperm bank showed that altruistic as well as financial motives were the main factors for becoming a donor. However, when the compensation was increased 100% in 2004 (to DKK 500) it had no significant impact on neither the numbers of new donor candidates coming in nor the frequency of donations from the existing donors. When the compensation was reduced to the previous level (DKK 250) again one year later in 2005 there was no effect either. This led to the assumption that altruism is the main motive and that financial compensation is secondary.

Equipment to collect, freeze and store sperm is available to the public notably through certain US outlets, and some donors process and store their own sperm which they then sell via the Internet.

The selling price of processed and stored sperm is considerably more than the sums which are received by donors. Treatments with donor sperm are generally expensive and are seldom available free of charge through national health services. Sperm banks often package treatments into e.g. three cycles, and in cases of IVF or other ART treatments, they may reduce the charge if a patient donates any spare embryos which are produced through the treatment. There is often more demand for fertility treatment with donor sperm than there is donor sperm available, and this has the effect of keeping the cost of such treatments reasonably high.

Onselling

There is a market for vials of processed sperm and for various reasons a sperm bank may sell-on stocks of vials which it holds (known as 'onselling'). Onselling therefore enables a sperm bank to maximize the sale and disposal of sperm samples which it has processed. The reasons for onselling may be where part of, or even the main business of, a particular sperm bank is to process and store sperm rather than to use it in fertility treatments, or where a sperm bank is able to collect and store more sperm than it can use within nationally set limits. In the latter case a sperm bank may sell on sperm from a particular donor for use in another jurisdiction after the number of pregnancies achieved from that donor has reached its national maximum.

A UK sperm bank however, may only onsell sperm before the national limit of ten families has been achieved from one donor within the UK. This means, for example, that a sperm bank may recruit a donor and prepare samples for ICI, IUI and ART use from his donations. After 9 months it is able to release the 10 or so samples donated within the first 3 months, from 6 month quarantine ( approximately 100 vials) and it uses these to achieve 6 pregnancies (although more pregnancies could, of course, be achieved from the number of vials prepared as illustrated). The sperm bank is then able to onsell sperm from that donor to sperm banks and clinics outside the UK and it can illustrate the fecundity of the various types of samples it sells from the pregnancy rates it has achieved. However, from April 2010, the HFEA has imposed limitations on exports of an individual's sperm. The donor must now agree to the export and to the use of his donations to a particular country, and he must be told that regulations for use in that country will vary. He must not have put a limit on the number of births which may be achieved from his donations. The HFEA must be notified of exports of sperm from the UK which will only be granted in accordance with 'special directions'. Individual clinics exporting sperm or onselling to other UK clinics are now responsible for ensuring that the maximum number of births produced from each donor is not exceeded. Prior to 2010 UK clinics could export any quantity of an individual's sperm samples without the consent of the HFEA provided that the donor had consented generally to export and had not imposed a limit on the number of children born from his sperm.

The regulations introduced in April 2010 are intended to ensure that no more than ten families are produced from each donor, regardless of where this occurs. Before this time, some men donated for periods in excess of two years (some for even four or five years) and vials of their sperm were exported without limitation provided that not more than ten families had been produced from their samples in the UK at the time of the export. Donors with particular blood groups or with sperm which produced higher than average pregnancy rates were sometimes offered the opportunity to donate for such prolonged periods. Although this gave rise to considerable numbers of offspring from such donors, local rules applied where the treatments were carried out and there was probably only a low risk of consanguinity. Donors who donated over such periods of time were also aware that their sperm would be used to create numerous offspring.

Embryos may also be onsold. These are usually spare embryos which are created through IVF treatment where a woman achieves the number of pregnancies she requires and the resulting embryos may therefore be disposed of. Donor sperm (and donor eggs) may be used in IVF treatments, and as many as eighteen eggs may be fertilized using one vial of donor sperm, although only the most viable of these will be subsequently implanted in a woman in an attempt to achieve a pregnancy. In the case of the UK, the consent of the donors of both the egg and the sperm which were used to create the embryo must be obtained, and the limit of ten families produced from each donor must not be exceeded.

Onselling is normally only appropriate where the donor remains anonymous. Sperm banks purchasing sperm samples may in turn onsell these to other sperm banks and often engage in the process of exchanging samples with other sperm banks. This is a common practice which enables sperm banks to offer a wider variety of donors, as well as to onsell samples from donors who have reached the maximum permitted number of offspring imposed by, or on, that clinic. Onselling may therefore give rise to numerous pregnancies being produced from individual donors which can sometimes total 100 or more (see above 'Limitation' and the associated link) particularly where a sperm donor donates his sperm for a period of two years or more and where his samples are prepared for IVF use. Sperm from certain donors, such as those with particular blood groups, physical features or intellect, may also be more in demand than sperm from other donors. However, in every case rules as to use and the limitation on the number of pregnancies which apply locally will reduce the risk of consanguinity. The lack of overall records as to use and success will mean that the numbers of pregnancies achieved from the samples of an individual donor will not exist and the donor will not be at risk of knowing the large number of births that were produced from the samples he donated.

Sperm may also be sold on for research or educational purposes, usually after the number of births from the donor concerned has reached its maximum. Sperm is used for genetic and fertility testing, and also for research into birth control.

Psychological issues

Further information: Donor conceived people#Psychological and social

Common reasons to donate are to help childless couples, and, for some, the monetary compensation. Reluctance to donate may be caused by a sense of ownership and responsibility for the well-being of the offspring.

Telling the child

Many donees do not tell the child that they were conceived as a result of sperm donation, or, when non-anonymous donor sperm has been used, they do not tell the child until they are old enough for the clinic to provide the contact information about the donor. Some believe that it is a human right for a person to know who their biological mother and father are, and thus it should be illegal to conceal this information in any way and at any time.

However, there are certain circumstances where the child very likely should be told:

• When many relatives know about the insemination, so that the child might find it out from somebody else.
• When the husband carries a significant genetic disease, relieving the child from fear of being a carrier.

Families sharing same donor

Having contact and meeting among families sharing the same donor generally has positive effects. It gives the child an extended family and helps give the child a sense of identity by answering questions about the donor. It is more common among open identity-families headed by single women. Less than 1% of those seeking donor-siblings find it a negative experience, and in such cases it is mostly where the parents have disagreed with each other about how the relationship should proceed.

Other family members

Parents of donors, who are the grandparents of donor offspring and may therefore be the oldest surviving progenitors, may regard the donated genetic contribution as a family asset, and may regard the donor conceived people as their grandchildren.

Support for donors

In the UK, the National Gamete Donation Trust is a charity which provides information, advice and support for people wishing to become egg, sperm or embryo donors. The Trust runs a national helpline and online discussion list for donors to talk to each other.

Cases not to donate

Pennsylvania Court Orders Sperm Donor to Lesbian Couple to Pay Child Support

Tom Leykis discusses a story of a man who donated sperm and now has to pay child support even though he and the woman had an agreement that he would not be financially responsible.

Ethical and legal Issues

Anonymity

Anonymous sperm donation is where the child and/or receiving couple will never get to know the identity of the donor, and non-anonymous when they will. A donor who makes a non-anonymous sperm donation is termed a known donor, open identity or identity release donor.

Non-anonymous sperm donors are, to a substantially higher degree, driven by altruistic motives for their donations.

Even with anonymous donation, some information about the donor may be released to the woman/couple at the time of treatment. limited donor information includes height, weight, eye, skin and hair colour. In Sweden, this is all the information a receiver gets. In the US, on the other hand, additional information may be given, such as a comprehensive biography and sound/video samples.

For most sperm recipients, anonymity of the donor is not of major importance at the obtainment or tryer-stage,. Anonymous sperm tends is often cheaper, but another that recipients choose anonymous donors is concern about the role that the donor or the child may want the donor to play in the child's life. On the other hand, they may prefer a non-anonymous donor if they anticipate that their child will know that they were born from donor sperm and seek more information about their donor in the future. A Dutch study found that lesbian couples significantly more likely (98%) to choose non-anonymous donors than heterosexual couples (63%), among whom 83% did not intend to ever inform their child even of the fact that they were born of donor sperm.

For some donor offspring, information about their donor is important. For some donor conceived children, on the other hand, it may be psychologically burdensome not having the possibility of contacting or knowing almost nothing about the biological father. Thus far, studies have found that a significant minority of donor conceived children want information about their biological father.

Several jurisdictions, e.g. Sweden, Norway, the Netherlands, Britain, Switzerland, Australia and New Zealand, and others, only allow non-anonymous sperm donation, generally based on the principle that the child has a right to knowledge of his/her biological origins. Generally this is implemented by requiring sperm banks to keep up to date records and release identifying information about the donor to his offspring after they reach a certain age (15-18). See Sperm donation laws by country

Donor tracking

Even when donors choose to be anonymous, offspring may still find ways to learn more about their biological origins. Registries and DNA-databases have been developed for this purpose. Registries that help donor-conceived offspring identify half-siblings from other mothers also help avoid accidental incest in adulthood.

Tracking by registries

Further information: Donor sibling registration

Offspring of anonymous donors may often have the ability to obtain their biological father's donor number from the fertility clinic or sperm bank used for their birth. They may then share their number on a registry. By finding shared donor numbers, offspring may find their genetic half-siblings. The donor may also find his number on a registry and choose to make contact with his offspring or otherwise reveal his identity.

Tracking by DNA-databases

Even sperm donors who have chosen anonymity and not to contact their offspring through a registry are now increasingly being traced by their children. Improved DNA technology has brought into question the possibility of assuring a donor's anonymity. For example, at least one child found his biological father using his own DNA test and internet research, and was able to identify and contact his anonymous donor.

Fertility tourism and international sperm markets

Further information: Fertility tourism#Donor insemination destinations

Different factors motivate individuals to seek sperm from outside their home state. For example, some jurisdictions do not allow unmarried women to receive donor sperm. Jurisdictional regulatory choices as well as cultural factors that discourage sperm donation have also led to international fertility tourism and sperm markets.

Sweden

When Sweden banned anonymous sperm donation in 1980, the number of active sperm donors dropped from approximately 200 to 30. Sweden now has an 18 month long waiting list for donor sperm. At least 250 Swedish sperm recipients travel to Denmark annually for insemination. Some of this is also due to the fact that Denmark also allows single women to be inseminated.

United Kingdom

After the United Kingdom ended anonymous sperm donation in 2005, the numbers of sperm donors went up, reversing a three-year decline. However, there is still a shortage, and some doctors have suggested raising the limit of children per donor. Some UK clinics import sperm from Scandinavia.

Despite the shortage, sperm exports from the UK are legal (subject to the EU Directive on Tissue Exports) and donors may remain anonymous in this context. In 2009 one Danish clinic secured the approval of the HFEA to import sperm via registered clinics for use in the UK. The sperm must have been processed, stored and quarantined in compliance with UK regulations. The donors have agreed to be identified when the children produced with their sperm reach the age of eighteen. The number of children produced from such donors in the UK will, of course, be subject to HFEA rules (i.e. currently a limit of ten families,) but the donors' sperm may be used worldwide in accordance with the clinic's own limit of one child per 200.000 of population, subject to national or local limits which apply.

Korea

Korean Bioethics Law prohibits selling and buying of sperm between clinics, and each donor may only help giving rise to a child to one single couple. It suffers from a shortage.

Canada

Canada prohibits payment for gamete donation beyond the reimbursement of expenses. Many Canadians import purchased sperm from the United States.

United States

The United States, which permits monetary compensation for sperm donors, has had an increase in sperm donors during the late 2000s recession

Social Controversy

The use of sperm donation is increasingly popular among single women and lesbians. Indeed, some sperm banks and fertility clinics, particularly in the US, Denmark and the UK have a predominance of women being treated with donor sperm who come within these groups and their publicity is aimed at them. This produces many ethical issues around the ideals of conventional parenting and has wider issues for society as a whole, including the issues of the role of men as parents, the issue of family support for children, and the issue of financial support for women with children.

The growth of sperm banks and fertility clinics, the use of sperm agencies and the availability of anonymous donor sperm have served to make the use of sperm donation a more respectable, and therefore a more socially acceptable, procedure. The intervention of doctors and others may be seen as making the whole process a respectable and merely a medical procedure which raises no moral issues, where donor inseminations may be referred to as 'treatments' and donor children as 'resulting from the use of a donor's sperm', or 'born following donaton' and subsequent children may be described as 'born using the same donor' rather than as biological children of the same man.

A study has indicated that both men and women view the use of donor sperm with more skepticism compared with the use of donor eggs, suggesting a unique underlying perception regarding the use of male donor gametes.

As acceptance of sperm donation has generally increased, so has the level of questioning as to whether 'artificial' means of conception are necessary, and some donor children too, have been critical of the procedures which were taken to bring them into the world. Against this background has been the increase in the use of NI as a method of sperm donation. However, while some donors may be willing to offer this as a method of impregnation, it has many critics and it also raises further legal and social challenges.

Some donor children grow up wishing to find out who their fathers were, but others may be wary of embarking on such a search since they fear they may find scores of half-siblings who have been produced from the same sperm donor. Even though local laws or rules may restrict the numbers of offspring from a single donor, there are no worldwide limitations or controls and most sperm banks will onsell and export all their remaining stocks of vials of sperm when local maxima have been attained (see 'onselling' above).

One item of research has suggested that donor children have a greater likelihood of substance abuse, mental illness and criminal behavior when grown.[2] However, its motivation and credibility have been questioned.[3]

Religious responses

Further information: Religious response to assisted reproductive technology

There are a wide range of religious responses to sperm donation, with some religious thinkers entirely in support of the use of donor sperm for pregnancy, some who support its use under certain conditions, and some entirely against.

Catholicism

Catholicism officially opposes the use of donor sperm on the basis that it compromises the sexual unity of the marital relationship and the idea "that the procreation of a human person be brought about as the fruit of the conjugal act specific to the love between spouses."

Judaism

Jewish thinkers hold a broad range of positions on sperm donation. Most Jewish communities have approved the use of donor insemination at least in some form, and liberal communities accept it entirely.

The questions considered by rabbis who make rulings based on traditional Jewish law include:

• Whether sperm donation is considered wasting seed: This tends to be a concern only amongst the most traditional rabbis, and they generally hold that sperm donation for the purpose of procreation is not considered a waste of seed.
• Whether donor insemination of a married woman may be considered adultery: Only held by a tiny minority, but many Orthodox rabbis frown on the practice.
• Whether the sperm donor is considered the father for purposes of consanguinity: generally the answer is yes, which among traditional authorities has led to a preference for either known or non-Jewish donors.

History

In 1790, Scottish anatomist and surgeon Dr. John Hunter reported that he had successfully inseminated the wife of a linen draper using her husband's sperm.^{[citation needed]}

In 1884, Professor William Pancoast of Philadelphia's Jefferson Medical College performed an insemination on the wife of a sterile Quaker merchant. Instead of taking the sperm from the husband, the professor chloroformed the woman, then let his medical students vote which one of among them was "best looking", with that elected one providing the sperm for the insemination. At the husband's request, his wife was never told how she became pregnant. As a result of this medical school experiment, the merchant's wife gave birth to a son, who became the first known child by donor insemination.

The case was revealed in 1909, when a letter by Addison Davis Hard appeared in the American journal Medical World, highlighting the procedure which had taken place at the Jefferson Medical College in Philadelphia in 1884 — twenty-five years earlier.

From that time, a few doctors began to perform donor insemination privately. Such procedures were regarded as intensely private, if not secret, by the parties involved. Records were usually not maintained so that donors could not be identified for paternity proceedings. Technology permitted the use of fresh sperm only, and it is thought that sperm largely came from the doctors and their male staff, although occasionally they would engage private donors who were able to donate on short notice on a regular basis.^{[citation needed]}

The first successful human pregnancy using frozen sperm was in 1953.^{[citation needed]}

Donor insemination remained virtually unknown to the public until 1954. In that year the first comprehensive account of the process was published in The British Medical Journal.^{[citation needed]}

Donor insemination provoked heated public debate. The Archbishop of Canterbury established the first in a long procession of commissions that, over the years, inquired into the practice. It was at first condemned by the Lambeth Conference, which recommended that it be made a criminal offence. A Parliamentary Commission agreed. In Italy, the Pope declared donor insemination a sin, and proposed that anyone using the procedure be sent to prison.^{[citation needed]}

In many western countries, sperm donation is now a largely accepted procedure. In the US and elsewhere, the growth in the number of sperm banks has been considerable. A sperm bank in the US pioneered the use of on-line search catalogues for donor sperm, and these facilities are now widely available on the websites of sperm banks and fertility clinics.^{[citation needed]}

Recent years have also seen sperm donation become relatively less popular among heterosexual couples, who now have access to more sophisticated fertility treatments, and more popular among single women and lesbian couples - whose access to the procedure is relatively new and still prohibited in certain jurisdictions.^{[citation needed]}

United States

In 1954, the Supreme Court of Cook County, Illinois ruled that regardless of a husband's consent, donor insemination was "contrary to public policy and good morals, and considered adultery on the mother's part." The sperm donor was not married to the child's mother, and therefore, regardless of her husband's consent, the woman's insemination constituted adultery. The ruling went on to say that, "A child so conceived, was born out of wedlock and therefore illegitimate. As such, it is the child of the mother, and the father has no rights or interest in said child."

However, the following year, Georgia became the first state to pass a statute legitimizing children conceived by DI, on the condition that both the husband and wife consented in advance in writing to the procedure.^{[citation needed]}

In 1973 the Commissioners on Uniform State Laws, and a year later, the American Bar Association, approved the Uniform Parentage Act. This act provides that if a wife is artificially inseminated with donor semen under a physician's supervision, and with her husband's consent, the husband is legally considered the natural father of the DI child. That law was followed by similar legislation in many states.^{[citation needed]}

In 1975, the first commercial sperm bank, Xytex Corporation, was opened in Augusta, GA by Dr. Armand Karow Jr. and Dr. John Black.^{[citation needed]}

United Kingdom

In the UK, the Warnock Committee considered issues of gamete donation and assisted reproduction techniques. Donor insemination was already available in the UK through unregulated clinics such as BPAS. The Committee's report led to the passing of the Human Fertilisation and Embryology Act in 1990. That act provided for a system of licensing for fertility clinics and procedures. It also provided that, where a man donates sperm at a licensed clinic in the UK and his sperm is used at a UK clinic to impregnate a woman, the man is not legally responsible for the resulting child. The 1990 Act also established a UK central register of donors and donor births to be maintained by the Human Fertilisation and Embryology Authority (the 'HFEA'), a supervisory body established by the Act. Following the Act, for any act of sperm donation through a licensed UK clinic that results in a living child, information on the child and the donor must be recorded on the register. This measure was intended to reduce the risk of consanguinity as well as to enforce the limit on the number of births permitted by each donor. The natural child of any donor has access to non-identifying information about their donor, starting at the child's eighteenth birthday.

The emphasis of the 1990 Act was on protecting the unborn child. However, a general shortage of donor sperm at the end of the 20th century, exacerbated by the announcement of the removal of anonymity in the UK, led to concerns about the excessive use of the sperm of some donors. These concerns centered on the export and exchange of donor sperm with overseas clinics, and also the interpretation of the term 'sibling use' to include donated embryos produced from one sperm donor, and successive births by surrogates using eggs from different women but sperm from the same sperm donor. Donors were informed that up to ten births could be produced from their sperm, but the words 'other than in exceptional circumstances' in the consent form could potentially lead to many more pregnancies. These concerns led to the SEED Report commissioned by the HFEA, which was in turn followed by new legislation and rules meant to protect the interests of donors: When a man donates his sperm through a UK clinic, that sperm is not permitted to give rise to more than ten families total, anywhere in the world.

International comparison

Further information: Sperm donation laws by country

On the global market, Denmark has a well-developed system of sperm export. This success mainly comes from the reputation of Danish sperm donors for being of high quality and, in contrast with the law in the other Nordic countries, gives donors the choice of being either anonymous or non-anonymous to the receiving couple. Furthermore, Nordic sperm donors tend to be tall, with rarer features like blond hair or different color eyes and a light complexion, and highly educated and have altruistic motives for their donations, partly due to the relatively low monetary compensation in Nordic countries. More than 50 countries worldwide are importers of Danish sperm, including Paraguay, Canada, Kenya, and Hong Kong. Several UK clinics also export donor sperm but they must take steps to ensure that the maximum number of ten families produced from each donor is not exceeded. The use of the sperm outside the UK will also be subject to local rules. Within the EU there are now regulations governing the transfer of human tissue including sperm between member states to ensure that these take place between registered sperm banks. However, the Food and Drug Administration (FDA) of the US has banned import of any sperm, motivated by a risk of mad cow disease, although such a risk is insignificant, since artificial insemination is very different from the route of transmission of mad cow disease. The prevalence of mad cow disease is one in a million, probably less for donors. If prevalence was the case, the infectious proteins would then have to cross the blood-testis barrier to make transmission possible. Transmission of the disease by an insemination is approximately equal to the risk of getting killed by lightning.

Fictional representation

Movie plots involving artificial insemination by donor are seen in Made in America, Road Trip, The Back-Up Plan, The Kids Are All Right (film), The Switch (film), and Baby Mama, the latter also involving surrogacy.

Films and other fiction depicting emotional struggles of assisted reproductive technology have had an upswing first in the latter part of the 2000s decade, although the techniques have been available for decades. Yet, the amount of people that can relate to it by personal experience in one way or another is ever growing, and the variety of trials and struggles is huge.

A 2012 Bollywood comedy movie Vicky Donor, was based on sperm donation. The film release saw an impact, wherein the number of men donating sperm increased in India.

See also

• Accidental incest
• Artificial insemination
• Conception device
• Donor conceived people
• Egg donor
• Infertility
• IVF
• McD v. L
• Posthumous sperm retrieval
• Rh Disease
• Semen quality
• Sperm bank
• Sperm donation laws by country
• Surrogacy
• Third party reproduction

References

External links

• Sperm donation in the UK (the UK's regulatory body - lists all UK clinics offering sperm donation)
• Sperm donors
• Sperm Donation at the Open Directory Project

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. ドナー授精 donor insemination
• 2. 男性不妊症の治療 treatment of male infertility
• 3. Medical care of sexual minority women
• 4. Use of assisted reproduction in HIV- and hepatitis-infected couples
• 5. 妊娠中の非Rh（D）RBC同種抗体のマネージメント management of non rh d red blood cell alloantibodies during pregnancy

English Journal

• Does anonymous sperm donation increase the risk for unions between relatives and the incidence of autosomal recessive diseases due to consanguinity?

• Serre JL1, Leutenegger AL, Bernheim A, Fellous M, Rouen A, Siffroi JP.
• Human reproduction (Oxford, England).Hum Reprod.2014 Mar;29(3):394-9. doi: 10.1093/humrep/det452. Epub 2013 Dec 16.
• In France gamete donation and notably sperm donation are anonymous. It has been claimed that anonymous artificial insemination by donor (AID) could highly contribute to an increase in the level of consanguinity and the incidence of autosomal recessive diseases, due to the unions between offspring of
• PMID 24345578

• The attitudes of infertile male patients toward the use of artificial insemination by donor: a korean regional survey.

• Hwang DS, Jeon TG, Park HJ, Park NC.
• Korean journal of urology.Korean J Urol.2014 Feb;55(2):134-9. doi: 10.4111/kju.2014.55.2.134. Epub 2014 Feb 14.
• PURPOSE: Infertile couples interested in nonspouse artificial insemination by donor (AID) not only require a thorough understanding of the medical procedure but also must scrutinize the effects it will have on family relationships, including those on the infant to be born. We conducted a series of s
• PMID 24578811

• Cyclic changes and relationship between peripheral and endometrial NK cells from women with repeated failure after artificial insemination by donor sperm.

• Zhang Y1, Kwak-Kim J, Huang D, Hu L, Liao A.
• American journal of reproductive immunology (New York, N.Y. : 1989).Am J Reprod Immunol.2014 Jan;71(1):44-54. doi: 10.1111/aji.12159. Epub 2013 Sep 16.
• PROBLEM: Cyclic changes of peripheral natural killer (pNK) cells and/or endometrial NK (eNK) cells during menstrual cycle remain controversial, and their relationship remains uncertain.METHOD OF STUDY: Peripheral blood and endometrial biopsies were simultaneously obtained from women (n = 23) undergo
• PMID 24102854

Japanese Journal

• 「アクター」としての非配偶者間人工授精(AID)児 : 新聞記事の分析を通して

• 竹家 一美
• 年報社会学論集 (28), 52-63, 2015
• NAID 40020562161

• シンポジウム報告 男性不妊の不可視化と母性保護概念 : 非配偶者間人工授精は誰のための処置だったのか?

• 由井 秀樹
• 家族研究年報 = Annals of family studies (40), 7-23, 2015
• NAID 40020554180

• 日本における非配偶者間人工授精の導入と産婦人科学における男性不妊研究の展開 : 産婦人科医向け雑誌の分析から

• 由井 秀樹
• 科学史研究. 第II期 52(268), 177-186, 2013-12-24
• … The paper shows how artificial insemination by donor (AID) was introduced into the study of obstetrics and gynecology in Japan as a part of male infertility studies. … First, the introduction of AID by Ando Kakuichi, who was an obstetrician and gynecologist at Keio University was related to contraception studies; …
• NAID 110009863975

Related Links

• Donor insemination - Evidence-Based Clinical Decision ...

Artificial insemination refers to the introduction of semen into the vagina, uterus, or oviduct by a means other than sexual intercourse. When the procedure is performed using sperm from a man other than the patient's partner, it is ...

• Artificial Insemination with Donor Sperm | Eugin IVF Clinic

Artificial Insemination with donor sperm (AID) consists of placing sperm obtained from a sperm donor inside the uterus. It offers a 33% chance of pregnancy ... Cost of treatment Thanks to our 15 years of experience with patients from ...

Related Pictures

---

★リンクテーブル★

リンク元	「非配偶者間人工授精」
関連記事	「donor」「artificial」「insemination」

「非配偶者間人工授精」

　　[★]

英

artificial insemination by donor, artificial insemination with donor's semen AID, heterologous insemination

関

人工授精

「donor」

　　[★]

• n.

• ドナー、提供者、臓器提供者、供与者、(化学)供与体

関

organ donor、provider、tissue donor

　 　 　

「artificial」

　　[★]

• adj.

• 人工の、人工的な、人為的な

関

artificially

　 　 　 　

「insemination」

　　[★]

• n.

• 精子注入、媒精、授精

関

inseminate