アポクリン腺
WordNet
- any of various organs that synthesize substances needed by the body and release it through ducts or directly into the bloodstream (同)secretory organ, secretor, secreter
- (of exocrine glands) producing a secretion in which part of the secreting cell is released with the secretion; "mothers milk is one apocrine secretion"
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- (生物体内の)腺(せん)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/13 15:13:08」(JST)
[Wiki en表示]
| Exocrine Secretion
|
| Merocrine or eccrine – by exocytosis |
| Apocrine – by membrane budding (loss of cytoplasm) |
| Holocrine – by membrane rupture |
Apocrine is a term used to classify exocrine glands in the study of histology. Cells which are classified as apocrine bud their secretions off through the plasma membrane producing membrane-bound vesicles in the lumen.The apical portion of the secretory cell of the gland pinches off and enters the lumen. It loses part of its cytoplasm in their secretions. Apocrine glands are found around armpits & the nipples and the groin regions of the body. Apocrine is functional during hormonal stress or puberty.
Secretion occurs when the release of secretory materials is accompanied with loss of part of cytoplasm. Apocrine secretion is less damaging to the gland than holocrine secretion (which destroys a cell) but more damaging than merocrine secretion (exocytosis). An example of true apocrine glands are mammary glands, responsible for secreting breast milk.[1]
Contents
- 1 Apocrine Metaplasia
- 2 Apocrine Carcinoma
- 3 References
- 4 External links
Apocrine Metaplasia
Main article: Metaplasia
Apocrine Metaplasia is a reversible transformation of cells to an apocrine phenotype. It is common in the breast in the context of fibrocystic change. It is seen in women mostly over the age of 50 years. Metaplasia happens when there is an irritation to the breast (breast cyst). Apocrine-like cells form in a lining of developing microcysts, due to the pressure buildup within the lumen. The pressure build up is caused by secretions.[2] The chance of developing breast cancer increases when metaplasia proliferates.
Apocrine Carcinoma
Apocrine Carcinoma is a very rare form of female breast cancer. The rate of incidence varies from 0.5 to 4%.[3] Cytologically, the cells of apocrine carcinoma are relatively large, granular, and it has a prominent eosinophilic cytoplasm.[4] When Apocrine Carcinoma is tested as a “triple negative”, it means that the cells of the patient cannot express the estrogen receptor, progesterone receptor, or HER2 receptor.[5]
References
- ^ Mescher AL, "Chapter 4. Epithelial Tissue" (Chapter). Mescher AL: Junqueira's Basic Histology: Text & Atlas, 12e: http://www.accessmedicine.com/content.aspx?aID=6180489.
- ^ Dr Ayush Goel and Radswiki et al. Apocrine metaplasia of the breast.http://radiopaedia.org/articles/apocrine-metaplasia-of-the-breast
- ^ Khandeparkar, Siddhi Gaurish Sinai, Sanjay D. Deshmukh, and Pallavi D. Bhayekar. "A rare case of apocrine carcinoma of the breast: Cytopathological and immunohistopathological study." Journal of Cytology/Indian Academy of Cytologists 31.2 (2014): 96.
- ^ http://path.upmc.edu/cases/case209/dx.html (accessed November 3, 2014)
- ^ http://www.hopkinsmedicine.org/kimmel_cancer_center/centers/breast_cancer_program/rare_tumors/apocrine_breast_cancer (accessed October 28, 2014)
External links
- 1624244281 at GPnotebook
- Diagram at uwa.edu.au
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Epithelial tissue
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| Cells |
- Columnar
- Cuboidal
- Squamous
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| Types |
- Simple squamous epithelium
- Simple cuboidal epithelium
- Simple columnar epithelium
- Pseudostratified columnar epithelium
- Stratified squamous epithelium
- Stratified cuboidal epithelium
- Stratified columnar epithelium
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| Glandular |
| Classification |
| Mechanism |
- Merocrine
- Apocrine
- Holocrine
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| Shape |
- Tubular gland
- Alveolar gland
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| Secretion |
- Serous glands
- Mucous glands
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| Components |
- Myoepithelial cell
- Serous demilune
- Ducts:
- Interlobar
- Interlobular
- Intralobular
- Striated
- Intercalated
- Acinus/Lobe
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- See also
- Template:Epithelial neoplasms
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UpToDate Contents
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English Journal
- Pathogenesis and pharmacotherapy of Hidradenitis suppurativa.
- Nazary M, van der Zee HH, Prens EP, Folkerts G, Boer J.SourceDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, P.O. Box 80.082, 3508 TB Utrecht, The Netherlands. Maiwand_Nazary@live.nl
- European journal of pharmacology.Eur J Pharmacol.2011 Dec 15;672(1-3):1-8. Epub 2011 Sep 14.
- The focus of this review is to discuss the pathogenesis and the pharmacotherapy of Hidradenitis suppurativa (HS). HS is a distressing chronic skin disorder characterized by abscesses, boils, fistulas and scarring, generally affecting the groins, anogenital area and axillae. It is a common disease wi
- PMID 21930119
- An invasive adenocarcinoma of the accessory parotid gland: a rare example developing from a low-grade cribriform cystadenocarcinoma?
- Nakatsuka SI, Harada H, Fujiyama H, Takeda K, Kitamura K, Kimura H, Nagano T, Ito M, Asada Y.AbstractABSTRACT: Low-grade cribriform cystadenocarcinoma (LGCCA) is a rare tumor of the salivary gland that exhibits clinically indolent behavior. In this paper, we present a case of invasive adenocarcinoma of the accessory parotid gland in a young male that exhibited histology suggestive of an association of LGCCA. A 27-year-old man presented with a subcutaneous tumor in his left cheek. The tumor was separated from the parotid gland and located on the masseter muscle. The tumor was resected, and the postoperative histological diagnosis was adenocarcinoma, not otherwise specified (ANOS). The tumor exhibited papillary-cystic and cribriform proliferation of the duct epithelium and obvious stromal infiltration. Some tumor nests were rimmed by myoepithelium positive for smooth muscle actin, p63, and cytokeratin 14, indicating the presence of intraductal components of the tumor. Tumor cells exhibited mild nuclear atypia, and some of them presented an apocrine-like appearance and had cytoplasmic PAS-positive / diastase-resistant granules and hemosiderin. Other cells had foamy cytoplasm with microvacuoles. Immunohistochemistry revealed that the almost all of the tumor cells were strongly positive for S-100. These histological findings suggest the possibility that ANOS might arise secondarily from LGCCA. This is an interesting case regarding the association between ANOS and LGCCA in oncogenesis.
- Diagnostic pathology.Diagn Pathol.2011 Dec 7;6(1):122. [Epub ahead of print]
- ABSTRACT: Low-grade cribriform cystadenocarcinoma (LGCCA) is a rare tumor of the salivary gland that exhibits clinically indolent behavior. In this paper, we present a case of invasive adenocarcinoma of the accessory parotid gland in a young male that exhibited histology suggestive of an association
- PMID 22151879
Japanese Journal
- Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion
- Ishikawa Toshihisa,Toyoda Yu,Yoshiura Koh-ichiro,Niikawa Norio
- Frontiers in Genetics 3, 306, 2013-01-02
- … Apocrine secretion occurs when the secretory process is accomplished with a partial loss of cell cytoplasm. … Gly180Arg) in the ABCC11 gene determines the type of earwax in humans has shed light on the novel function of this ABC (ATP-binding cassette) transporter in apocrine glands. … The wild-type (Gly180) of ABCC11 is associated with wet-type earwax, axillary osmidrosis, and colostrum secretion from the mammary gland as well as the potential risk of mastopathy. …
- NAID 120005293408
- 発汗の機序と発汗異常を伴う疾患 (教育セミナー アクセサリーオーガンとオーラルケアの香粧品学 : エチケットのサイエンス)
- Evidence for Association of the rs17822931-A Allele in ABCC11 with a Decreased Risk of Estrogen Receptor-negative Breast Cancer
- Sosonkina Nadiya,Starenki Dmytro,Gorovenko Nataliya,Gurtoviy Vadim,Nakashima Masahiro,Oikawa Masahiro,Ohta Tohru,Niikawa Norio
- Acta Medica Nagasakiensia 56(3), 63-67, 2012-01-00
- … The rs17822931 SNP of the human ABCC11 gene determines earwax types, and is also associated with some functions of apocrine glands, including the mammary gland. …
- NAID 110008767596
Related Links
- gland [gland] an aggregation of cells specialized to secrete or excrete materials not related to their ordinary metabolic needs. Glands are divided into two main groups, endocrine and exocrine. adj., adj glan´dular. The endocrine glands ...
- The apocrine sweat glands, associated with the presence of hair in human beings (as on the scalp, the armpit, and the genital region), continuously secrete a concentrated fatty sweat into the gland tube. Emotional stress stimulates ...
★リンクテーブル★
[★]
- 英
- apocrine sweat gland, apocrine gland
- ラ
- glandula sudorifera apocrina
- 同
- 大汗腺
- 関
- 汗腺、エクリン汗腺 エックリン汗腺、モル腺