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1. 進行性前立腺癌の治療に対する実験的アプローチ investigational approaches for the treatment of advanced prostate cancer
2. 筋萎縮性側索硬化症の病態修飾療法 disease modifying treatment of amyotrophic lateral sclerosis
3. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化 head and neck squamous cell carcinogenesis molecular and genetic alterations
4. 慢性リンパ性白血病の病態生理および遺伝学的特徴 pathophysiology and genetic features of chronic lymphocytic leukemia
5. 心不全の病態生理：神経体液性の適応 pathophysiology of heart failure neurohumoral adaptations

English Journal

Protective effect of pyrroloquinoline quinine on ultraviolet A irradiation‑induced human dermal fibroblast senescence in vitro proceeds via the anti‑apoptotic sirtuin 1/nuclear factor‑derived erythroid 2‑related factor 2/heme oxygenase 1 pathway.

Zhang C1, Wen C2, Lin J3, Shen G3.
Molecular medicine reports.Mol Med Rep.2015 Sep;12(3):4382-8. doi: 10.3892/mmr.2015.3990. Epub 2015 Jun 24.
The aim of the present study was to determine whether pyrroloquinoline quinine (PQQ) exerts a protective effect on ultraviolet A (UVA) irradiation‑induced senescence in human dermal fibroblasts (HDFs) and to elucidate its mechanism of action in vitro. A senescence model was constructed as follo
PMID 26126510

Purine analogue ENERGI-F706 induces apoptosis of 786-O renal carcinoma cells via 5'-adenosine monophosphate-activated protein kinase activation.

Hsu CY1, Lin CH2, Lin JT3, Cheng YF4, Chen HM3, Kao SH2.
Molecular medicine reports.Mol Med Rep.2015 Sep;12(3):4566-71. doi: 10.3892/mmr.2015.3906. Epub 2015 Jun 11.
Purine compounds are known to activate 5'-adenosine monophosphate-activated protein kinase (AMPK), which has important roles in treatments for renal cell carcinoma. The present study was aimed to investigate the effects of the purine analogue ENERGI‑F706 on the human renal carcinoma cell line 786�
PMID 26062651

Protective effects of allicin against ischemic stroke in a rat model of middle cerebral artery occlusion.

Zhang B1, Li F1, Zhao W2, Li J3, Li Q1, Wang W1.
Molecular medicine reports.Mol Med Rep.2015 Sep;12(3):3734-8. doi: 10.3892/mmr.2015.3883. Epub 2015 Jun 3.
Allicin, a molecule predominantly responsible for the pungent odor and the antibiotic function of garlic, exhibits various pharmacological activities and has been suggested to be beneficial in the treatment of various disorders. The present study aimed to elucidate the effect of allicin in cerebral
PMID 26045182

Direct Infection of Primary Salivary Gland Epithelial Cells by Human T Lymphotropic Virus Type I in Patients With Sjögren's Syndrome

Nakamura Hideki,Takahashi Yoshiko,Yamamoto-Fukuda Tomomi,Horai Yoshiro,Nakashima Yoshikazu,Arima Kazuhiko,Nakamura Tatsufumi,Koji Takehiko,Kawakami Atsushi
Arthritis & Rheumatology 67(4), 1096-1106, 2015-04
… The expression of proapoptotic molecules (e.g., cytochrome c and Fas) and antiapoptotic molecules (e.g., Bcl-2, Heme oxygenase 2, and Hsp27) was increased in the SGECs cocultured with HCT-5, showing that apoptosis of SGECs was not detected after coculture with HCT-5 or Jurkat cells. …
NAID 120005603845

MnSOD downregulation induced by extremely low 0.1 mGy single and fractionated X-rays and microgravity treatment in human neuroblastoma cell line, NB-1

Indo Hiroko P.,Tomiyoshi Tsukasa,Suenaga Shigeaki,Tomita Kazuo,Suzuki Hiromi,Masuda Daisuke,Terada Masahiro,Ishioka Noriaki,Gusev Oleg,Cornette Richard,Okuda Takashi,Mukai Chiaki,Majima Hideyuki J.
Journal of Clinical Biochemistry and Nutrition advpub(0), 2015
… The qRT-PCR results revealed that microgravity did not result in significant changes except for a upregulation of proapoptotic VDAC2, and downregulations of proapoptotic CASP9 and antiapoptotic MnSOD. … After 0.1 mGy fractionation irradiation, there was increased expression of proapoptotic APAF1 and downregulation of proapoptotic CYTC, VDAC2, VDAC3, CASP8, AIF, ANT1, and ANT2, as well as an increase in expression of antiapoptotic BCL2. …
NAID 130005087378

Luteolin Attenuates Doxorubicin-Induced Cytotoxicity to MCF-7 Human Breast Cancer Cells

Sato Yasunori,Sasaki Naoto,Saito Megu [他],Endo Nao,Kugawa Fumihiko,Ueno Akemichi
Biological and Pharmaceutical Bulletin 38(5), 703-709, 2015
… Levels of the antiapoptotic protein Bcl-2 in luteolin-treated MCF-7 cells were significantly higher than those in doxorubicin-treated MCF-7 cells. …
NAID 130005068095