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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/07 14:27:57」(JST)

Ampiroxicam (INN) is a non-steroidal anti-inflammatory drug. It is a prodrug of piroxicam.^[1]

References

^ Carty TJ, Marfat A, Moore PF, Falkner FC, Twomey TM, Weissman A (July 1993). "Ampiroxicam, an anti-inflammatory agent which is a prodrug of piroxicam". Agents Actions 39 (3-4): 157–65. doi:10.1007/BF01998969. PMID 8304243.

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Risk factors of symptomatic NSAID-induced small intestinal injury and diaphragm disease.

Ishihara M1, Ohmiya N, Nakamura M, Funasaka K, Miyahara R, Ohno E, Kawashima H, Itoh A, Hirooka Y, Watanabe O, Ando T, Goto H.
Alimentary pharmacology & therapeutics.Aliment Pharmacol Ther.2014 Sep;40(5):538-47. doi: 10.1111/apt.12858. Epub 2014 Jul 4.
PMID 25041257

Simultaneous determination for oxicam non-steroidal anti-inflammatory drugs in human serum by liquid chromatography-tandem mass spectrometry.

Shirako J1, Kawasaki M, Komine K, Kunisue Y, Terada M, Sasaki C, Irie W, Murakami C, Tonooka K, Tomobe K, Shinozuka T.
Forensic science international.Forensic Sci Int.2013 Apr 10;227(1-3):100-2. doi: 10.1016/j.forsciint.2012.11.016. Epub 2012 Dec 27.
PMID 23273940

Oxicam structure in non-steroidal anti-inflammatory drugs is essential to exhibit Akt-mediated neuroprotection against 1-methyl-4-phenyl pyridinium-induced cytotoxicity.

Tasaki Y1, Yamamoto J, Omura T, Noda T, Kamiyama N, Yoshida K, Satomi M, Sakaguchi T, Asari M, Ohkubo T, Shimizu K, Matsubara K.
European journal of pharmacology.Eur J Pharmacol.2012 Feb 15;676(1-3):57-63. doi: 10.1016/j.ejphar.2011.11.046. Epub 2011 Dec 7.
PMID 22182582

松山貴俊,吉村哲規,樋口哲郎,小林宏寿,石川敏昭,飯田聡,植竹宏之,安野正道,榎本雅之,杉原健一
日本消化器外科学会雑誌 41(8), 1625-1630, 2008-08-01
… 症例1は74歳の女性で,関節痛にてAmpiroxicam 27mg/日を5年前から内服していた.平成17年3月黒色便が出現し,小腸内規鏡検査にて回腸に潰瘍を認めた.Ampiroxicamの服用を中止し経過観察していたが,間歇的な腹痛が出現した.小腸内視鏡検査にて同部の輪状狭窄を認め,小腸部分切除術を施行した.症例2は82歳の女性で,数年前の心筋梗塞発症後Aspirin 100mg/日を内服していた.平成15年8月,血便が出現し,平成16年1月,間歇 …
NAID 110006863484

Drug delivery system in pain control Progression in peroral narcotics and non-steroidal anti-inflammatory drugs (NSAIDs):Progression in peroral narcotics and non-steroidal anti-inflammatory drugs(NSAIDs)

佐伯茂
Drug Delivery System 20(5), 521-529, 2005
… The former includes Voltaren SR Capsules and Inteban SP and the latter includes acemetacin, indomethacin farnesil, proglumetacin maleate, ampiroxicam and loxoprofen sodium. …
NAID 130000747974

藤澤健司,横山和博,宮本洋二,鎌田伸之,長山勝
TMJ : journal of Japanese Society for Temporomandibular Joint = 日本顎関節学会雑誌 15(3), 260-265, 2003-12-20
… The most frequently used drugs were ampiroxicam in NSAIDs, and tolperisone hydrochloride in muscle relaxants.<BR>As for prognosis in 134 cases, 15 cases (11.2%) were completely healed, 42 cases (31.3%) were almost completely healed, 35 cases (26.1%) had some improvements in their symptom, but 42 cases (31.3%) were not improved. …
NAID 10011843299

Ampiroxicam
Systematic (IUPAC) name
	(RS)-Ethyl 1-[2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)benzo[e]thiazin-4-yl]oxyethyl carbonate
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
Legal status	℞ (Prescription only);
Identifiers
CAS Number	99464-64-9
ATC code	None
PubChem	CID 2176
ChemSpider	2091
UNII	0PV32JZB1J
KEGG	D01397
ChEBI	CHEBI:31210
ChEMBL	CHEMBL1909052
Chemical data
Formula	C20H21N3O7S
Molar mass	447.46 g/mol
Chirality	Racemic mixture
	SMILES CCOC(=O)OC(C)OC1=C(N(S(=O)(=O)C2=CC=CC=C21)C)C(=O)NC3=CC=CC=N3 ;
	InChI InChI=1S/C20H21N3O7S/c1-4-28-20(25)30-13(2)29-18-14-9-5-6-10-15(14)31(26,27)23(3)17(18)19(24)22-16-11-7-8-12-21-16/h5-13H,4H2,1-3H3,(H,21,22,24) ; Key:LSNWBKACGXCGAJ-UHFFFAOYSA-N ;
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