WordNet
- a white crystalline substance used as an analgesic and antipyretic (同)amidopyrine
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/06/19 15:23:23」(JST)
[Wiki en表示]
Aminophenazone
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Systematic (IUPAC) name |
4-dimethylamino- 1,5-dimethyl- 2-phenylpyrazol- 3-one |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Pregnancy cat. |
? |
Legal status |
? |
Identifiers |
CAS number |
58-15-1 |
ATC code |
N02BB03 |
PubChem |
CID 6009 |
DrugBank |
DB01424 |
ChemSpider |
5787 Y |
UNII |
01704YP3MO Y |
KEGG |
D00556 Y |
ChEBI |
CHEBI:160246 Y |
ChEMBL |
CHEMBL288470 Y |
Chemical data |
Formula |
C13H17N3O |
Mol. mass |
231.29358 |
SMILES
- O=C2\C(=C(/N(N2c1ccccc1)C)C)N(C)C
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InChI
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InChI=1S/C13H17N3O/c1-10-12(14(2)3)13(17)16(15(10)4)11-8-6-5-7-9-11/h5-9H,1-4H3 Y
Key:RMMXTBMQSGEXHJ-UHFFFAOYSA-N Y
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Y (what is this?) (verify)
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Aminophenazone (or aminopyrine) is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests.[1]
References[edit]
- ^ "Aminophenazone — Compound Summary". PubChem. The National Library of Medicine. 2005-03-26. Retrieved June 12, 2008.
UpToDate Contents
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English Journal
- 13C-aminopyrine breath test accurately predicts long-term outcome of chronic hepatitis C.
- Rocco A, de Nucci G, Valente G, Compare D, D'Arienzo A, Cimino L, Perri F, Nardone G.SourceDepartment of Clinical and Experimental Medicine, Gastroenterology Unit, University of Naples Federico II, Naples, Italy.
- Journal of hepatology.J Hepatol.2012 Apr;56(4):782-7. Epub 2011 Dec 13.
- BACKGROUND & AIMS: Although numerous non-invasive tests are currently available to explore liver function and disease activity in patients with HCV-related chronic diseases, none of these indicate the likelihood of disease progression in the individual patient. We aimed at assessing the prog
- PMID 22173159
- Influence of different proton pump inhibitors on activity of cytochrome P450 assessed by [(13)C]-aminopyrine breath test.
- Kodaira C, Uchida S, Yamade M, Nishino M, Ikuma M, Namiki N, Sugimoto M, Watanabe H, Hishida A, Furuta T.SourceFirst Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.
- Journal of clinical pharmacology.J Clin Pharmacol.2012 Mar;52(3):432-9. Epub 2011 Mar 17.
- Aminopyrine is metabolized by cytochrome P450 (CYP) in the liver. The investigators evaluated influences of different PPIs on CYP activity as assessed by the [(13)C]-aminopyrine breath test ([(13)C]-ABT). Subjects were 15 healthy volunteers with different CYP2C19 status (5 rapid metabolizers [RMs],
- PMID 21415279
Japanese Journal
- Antiinflammatory and Antioxidant Effects of Aqueous Extract from Phellinus gilvus in Rats
- Kim Sung-Hwan,Lim Jeong-Hyeon,Moon Changjong,Park Soo-Hyun,Kim Sung-Ho,Shin Dong-Ho,Park Seung-Chun,Kim Jong-Choon
- JOURNAL OF HEALTH SCIENCE 57(2), 171-176, 2011
- … Four acute and chronic inflammation groups included the vehicle control group, positive control group (aminopyrine, 100 mg/kg), PG10 group (PG, 10 mg/kg), and PG20 group (PG, 20 mg/kg). …
- NAID 130000663116
- DDT摂取ラットの代謝変動に及ぼすアミノ酸混合食の影響と食餌フィチン酸
- 岡崎 由佳子,片山 徹之
- 藤女子大学紀要. 第II部 47, 1-7, 2010-03-31
- … This study was conducted to examine the effect of dietary 1.02% sodium phytate on growth, relative weights of tissues, serum cholesterol, liver triglyceride and hepatic aminopyrine N-demethylase activity in rats fed a casein-or amino acid-based diet with or without 0.07% 1,1,1-trichloro-2,2-bis (p-chlorophenyl)ethane(DDT) for 13 days. … Dietary DDT significantly elevated serum cholesterol and liver triglyceride levels, as well as the hepatic activity of aminopyrine N-demethylase. …
- NAID 110007648515
Related Links
- What Does Aminopyrine Mean? Quote Of The Day "Even a minor event in the life of a child is an event of that child's world and thus a wor..."-Gaston Bachelard MORE Enjoy Dictionary.com ad-free! Learn more Popular Searches ...
- ami·no·py·rine noun \ə-ˌ mē-nō-ˈ pī(-ə)r-ˌ ēn\ Definition of AMINOPYRINE: a crystalline compound C 13 H 17 N 3 O formerly used to relieve pain and fever but now largely abandoned for this purpose because of the occurrence of fatal ...
Related Pictures
★リンクテーブル★
[★]
- 英
- aminopyrine
- ラ
- aminopyrinum
- 同
- ピラミドン pyramidone、アミドピリン amidopyrine、アミノフェナゾン aminophenazone
- 関
- アミノフェナゾン
[★]
アミノフェナゾン
- 関
- aminopyrine
[★]
アミノピリン-N-脱メチル化酵素、アミノピリン-N-デメチラーゼ