関: aminopyrine

WordNet

a white crystalline substance used as an analgesic and antipyretic (同)amidopyrine

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/27 17:42:16」(JST)

wiki en

Aminophenazone (or aminopyrine) is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of agranulocytosis. A breath test with ¹³C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests.^[1] It is also used in measuring the total body water in the human body system.^[2]

References

^ ^a ^b Caubet, M. S.; Laplante, A.; Caillé, J.; Brazier, J. L. (4 Jan 2007). "[13C]Aminopyrine and [13C]Caffeine Breath Test: Influence of Gender, Cigarette Smoking and Oral Contraceptives Intake". Isotopes in Environmental and Health Studies 38 (2): 71–77. doi:10.1080/10256010208033314.
^ "Aminophenazone — Compound Summary". PubChem. The National Library of Medicine. 2005-03-26. Retrieved June 12, 2008.

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English Journal

Maternal dipyrone treatment during lactation in mice reduces maternal behavior and increases anxiety-like behavior in offspring.

Veronesi VB1, Batista TH1, Ribeiro AC1, Giusti-Paiva A1, Vilela FC2.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.Int J Dev Neurosci.2017 May;58:74-81. doi: 10.1016/j.ijdevneu.2017.02.005. Epub 2017 Feb 20.
PMID 28219765

Toxic responses of swimming crab (Portunus trituberculatus) larvae exposed to environmentally realistic concentrations of oxytetracycline.

Ren X1, Wang Z2, Gao B1, Liu P1, Li J3.
Chemosphere.Chemosphere.2017 Apr;173:563-571. doi: 10.1016/j.chemosphere.2017.01.078.
PMID 28152408

Transformation of aminopyrine in the presence of free available chlorine: Kinetics, products, and reaction pathways.

Cai MQ1, Feng L2, Zhang LQ1.
Chemosphere.Chemosphere.2017 Mar;171:625-634. doi: 10.1016/j.chemosphere.2016.12.033. Epub 2016 Dec 26.
PMID 28056449

Japanese Journal

Use of 3,5-dichloro-2-hydroxybenzenesulfonic acid/4-aminophenazone chromogenic system in direct enzymic assay of uric acid in serum and urine.

FOSSATI P.
Clin Chem 26, 227-231, 1980
NAID 10007024501

A New Metabolite of Aminopyrine (Aminophenazone) in Man, 4-Formylaminoantipyrine

井口定男,五郎丸毅,野田敦子
Chemical & pharmaceutical bulletin 23(4), 932-934, 1975-04-25
The metabolism and excretion of aminopyrine in man were examined after oral administration. On the gas chromatogram, the extract from urine showed an unknown peak sometimes which seems to be a new met …
NAID 110003621961

EFFECT OF ANTIPHLOGISTICS ON THE LEVEL OF BLOOD GLUCOSE IN THE RAT

天野靖子,高折修二
The Japanese Journal of Pharmacology 18(4), 430-435, 1968
… However, Dirscherl and Lutzmann (7) have observed only the inhibitory effect of aminophenazone on the reduction of ring A. …
NAID 130000836971

Related Pictures

★リンクテーブル★

リンク元	「アミノピリン」「アミノフェナゾン」

「アミノピリン」

Aminophenazone
Systematic (IUPAC) name
	4-Dimethylamino-1,5-dimethyl-2-phenylpyrazol-3-one
Clinical data
AHFS/Drugs.com	International Drug Names
Pharmacokinetic data
Metabolism	N-demethylation
Identifiers
CAS Number	58-15-1
ATC code	N02BB03 (WHO)
PubChem	CID 6009
DrugBank	DB01424
ChemSpider	5787
UNII	01704YP3MO
KEGG	D00556
ChEBI	CHEBI:160246
ChEMBL	CHEMBL288470
Chemical data
Formula	C13H17N3O
Molar mass	231.29358
	SMILES O=C2\C(=C(/N(N2c1ccccc1)C)C)N(C)C ;
	InChI InChI=1S/C13H17N3O/c1-10-12(14(2)3)13(17)16(15(10)4)11-8-6-5-7-9-11/h5-9H,1-4H3 ; Key:RMMXTBMQSGEXHJ-UHFFFAOYSA-N ;
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