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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/26 03:14:25」(JST)

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Amezinium metilsulfate (INN, trade name Regulton) is a sympathomimetic drug used for the treatment of low blood pressure. It has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake.^[1]^[2]

References

^ Araújo, D; Caramona, MM; Osswald, W (1983). "On the mechanism of action of amezinium methylsulphate on the dog saphenous vein". European Journal of Pharmacology 90 (2–3): 203–14. doi:10.1016/0014-2999(83)90238-8. PMID 6873182. edit
^ Lenke, D.; Gries, J.; Kretzschmar, R. (1981). "Pharmacology of amezinium, a novel antihypotensive drug. III. Studies on the mechanism of action". Arzneimittel-Forschung 31 (9a): 1558–1565. PMID 7197970. edit

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English Journal

Diffuse cerebrovascular dilation: Case report of amezinium metilsulfate-induced reversible cerebral vasoconstriction syndrome.

Kobayashi M1.
Cephalalgia : an international journal of headache.Cephalalgia.2015 May 27. pii: 0333102415588326. [Epub ahead of print]
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by recurrent thunderclap headaches with reversible cerebral vasoconstriction, and often precipitated by the postpartum state and vasoactive medications. We describe a case of a patient with RCVS induced by amezinium me
PMID 26016487

Amezinium metilsulfate, a sympathomimetic agent, may increase the risk of urinary retention in multiple system atrophy.

Sakakibara R1, Uchiyama T, Asahina M, Yoshiyama M, Yamanishi T, Hattori T.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society.Clin Auton Res.2003 Feb;13(1):51-3.
In 5 patients with multiple system atrophy, administration of 15 mg/day of amezinium metilsulfate, an adrenergic agent, during 6 months for the treatment of postural hypotension exacerbated post-micturition residuals as compared to that before treatment (178 ml versus 113 ml for a change of 37 %, p
PMID 12664248

[A case of successful treatment of postprandial syncope with combined use of amezinium metilsulfate and dihydroergotamine mesylate].

Adachi N1, Kondo A, Hayashi K.
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.Nihon Ronen Igakkai Zasshi.1999 Jul;36(7):499-502.
An 86-year-old man, with a history of old cerebral hemorrhage, experienced repeated syncope after the meal. The blood pressure significantly decreased at the onset of syncope, and postprandial hypotension (PPH) was diagnosed. In order to treat the syncope, we administered midodrine hydrochloride, am
PMID 10536458

Japanese Journal

仰臥位高血圧・立位低血圧を伴う糖尿病性腎症血液透析患者の血圧コントロール

田中勝喜,西口健介,高折光司 [他],村上徹,岸本聡子,玉置佐奈美,井ノ口眞澄美,左海佳奈子,門脇勧,織田浩彰,御厨亮子,桑原隆
日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 44(5), 449-453, 2011-05-28
67歳，女性．糖尿病性腎症による血液透析歴16年．週3回3.5時間の維持透析で，体重増加は基本体重（40.2 kg）の約4％である．起床時の血圧は190/90 mmHg，透析前座位血圧120/60 mmHg，透析開始直後（仰臥位）血圧200/90 mmHgにも上昇する．透析終了後起立により血圧が90/50 mmHgまで低下し，当日はほとんど起立できない状況が続いていた．透析中の仰臥位血圧上昇につい …
NAID 10029406867

糖尿病性軸索障害型多発ニューロパチーに合併した起立性低血圧の治療に関する一考察

長島康洋,國本雅也,久手堅司,村松和浩,丸山路之
末梢神経 = Peripheral nerve 19(2), 297-298, 2008-12-01
NAID 10025625448

糖尿病性腎症透析患者の血圧調節に関するamezinium metilsulfateの効果

黒巣恵美,草野英二,増永義則,雨宮守正,有坂弘明,安藤康宏,上野幸司,赤井洋一,久野宗寛,佐々木簾雄,松田嘉男,大場秀一,浅野泰
日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 34(9), 1233-1238, 2001-08-28
NAID 10008044100

「アメジニウム」

Amezinium metilsulfate
Systematic (IUPAC) name
	6-Methoxy-1-phenylpyridazin-1-ium-4-amine; methyl sulfate
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only);
Routes of; administration	Oral
Identifiers
CAS Registry Number	30578-37-1
ATC code	C01CA25
PubChem	CID: 71926
ChemSpider	64937
UNII	03NR868ICX
KEGG	D01304
ChEMBL	CHEMBL2106667
Chemical data
Formula	C12H15N3O5S
Molecular mass	313.32 g/mol
	SMILES COC1=[N+](N=CC(=C1)N)C2=CC=CC=C2.COS(=O)(=O)[O-];
	InChI InChI=1S/C11H11N3O.CH4O4S/c1-15-11-7-9(12)8-13-14(11)10-5-3-2-4-6-10;1-5-6(2,3)4/h2-8,12H,1H3;1H3,(H,2,3,4) ; Key:ZEASXVYVFFXULL-UHFFFAOYSA-N ;
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