関: amezinium metilsulfate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/15 16:22:29」(JST)

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Amezinium metilsulfate (INN, trade name Regulton) is a sympathomimetic drug used for the treatment of low blood pressure. It has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake.^[1]^[2]

References

^ Araújo, D; Caramona, MM; Osswald, W (1983). "On the mechanism of action of amezinium methylsulphate on the dog saphenous vein". European Journal of Pharmacology 90 (2-3): 203–14. doi:10.1016/0014-2999(83)90238-8. PMID 6873182. edit
^ Lenke, D.; Gries, J.; Kretzschmar, R. (1981). "Pharmacology of amezinium, a novel antihypotensive drug. III. Studies on the mechanism of action". Arzneimittel-Forschung 31 (9a): 1558–1565. PMID 7197970. edit

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English Journal

Diffuse cerebrovascular dilation: Case report of amezinium metilsulfate-induced reversible cerebral vasoconstriction syndrome.

Kobayashi M1.
Cephalalgia : an international journal of headache.Cephalalgia.2015 May 27. pii: 0333102415588326. [Epub ahead of print]
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by recurrent thunderclap headaches with reversible cerebral vasoconstriction, and often precipitated by the postpartum state and vasoactive medications. We describe a case of a patient with RCVS induced by amezinium me
PMID 26016487

Differences in skin sympathetic involvements between two chronic autonomic disorders: multiple system atrophy and pure autonomic failure.

Asahina M1, Akaogi Y, Yamanaka Y, Koyama Y, Hattori T.
Parkinsonism & related disorders.Parkinsonism Relat Disord.2009 Jun;15(5):347-50. doi: 10.1016/j.parkreldis.2008.08.001. Epub 2008 Sep 19.
OBJECTIVE: Certain stimuli evoke increased sweat secretion (sympathetic sweat response; SSwR) and reduced skin blood flow (skin vasomotor reflex; SkVR) in the palm/sole. We evaluated SSwR and SkVR in patients with multiple system atrophy (MSA) and pure autonomic failure (PAF).METHODS: SSwR and SkVR
PMID 18805037

[Cathecholamine].

Toya Y1, Ebina T, Umemura S.
Nihon rinsho. Japanese journal of clinical medicine.Nihon Rinsho.2004 Jun;62 Suppl 6:178-82.
PMID 15250291

Japanese Journal

仰臥位高血圧・立位低血圧を伴う糖尿病性腎症血液透析患者の血圧コントロール

田中勝喜,西口健介,高折光司,村上徹,岸本聡子,玉置佐奈美,井ノ口眞澄美,左海佳奈子,門脇勧,織田浩彰,御厨亮子,桑原隆
日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 44(5), 449-453, 2011-05-28
67歳，女性．糖尿病性腎症による血液透析歴16年．週3回3.5時間の維持透析で，体重増加は基本体重（40.2 kg）の約4％である．起床時の血圧は190/90 mmHg，透析前座位血圧120/60 mmHg，透析開始直後（仰臥位）血圧200/90 mmHgにも上昇する．透析終了後起立により血圧が90/50 mmHgまで低下し，当日はほとんど起立できない状況が続いていた．透析中の仰臥位血圧上昇につい …
NAID 10029406867

透析患者の敗血症性ショック, 透析時低血圧に対する低用量AVP投与の有効性についての検討

中田夕香子,田中杏,川西智子,越川真男,田中敬雄,桑原隆
日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 41(11), 779-784, 2008-11-28
カテコラミン抵抗性の敗血症性ショックや心原性ショックのみならず，透析時低血圧においても低用量arginine vasopressin（AVP）持続投与を行うことで循環動態の安定を図ることができるとの報告がある．今回われわれは，敗血症を合併した維持血液透析（hemodialysis：HD）患者5例（男性4例，女性1例，平均67.6歳（55～73歳）），敗血症を合併した慢性腎不全急性増悪 …
NAID 10023974387

178) Disopyramideとameziniumの併用療法が有効であった再発性喉頭腫瘍に伴う頸動脈洞症候群の一例(第105回日本循環器学会近畿地方会)

多田洋平,土井淳史,片岡亨,高木雅彦,葭山稔
Circulation journal : official journal of the Japanese Circulation Society 72(Supplement_III), 1110, 2008-10-20
NAID 110007011447

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リンク元	「アメジニウム」
拡張検索	「amezinium metilsulfate」

「アメジニウム」

Amezinium metilsulfate
Systematic (IUPAC) name
	6-Methoxy-1-phenylpyridazin-1-ium-4-amine; methyl sulfate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	30578-37-1
ATC code	C01CA25
PubChem	CID 71926
ChemSpider	64937
UNII	03NR868ICX
KEGG	D01304
Chemical data
Formula	C12H15N3O5S
Mol. mass	313.32 g/mol
	SMILES COC1=[N+](N=CC(=C1)N)C2=CC=CC=C2.COS(=O)(=O)[O-];
	InChI InChI=1S/C11H11N3O.CH4O4S/c1-15-11-7-9(12)8-13-14(11)10-5-3-2-4-6-10;1-5-6(2,3)4/h2-8,12H,1H3;1H3,(H,2,3,4) ; Key:ZEASXVYVFFXULL-UHFFFAOYSA-N ;
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